PubMed Health⌕ Search

Biomedical subjects

R Sieber

Publications and source records attributed to R Sieber.

28 records · Page 2Linked to original sources
PubMed1986

Endoscopy as final arbiter in controlled clinical trials in peptic disorders.

Endoscopy should not be the sole final arbiter in controlled clinical trials of peptic disorders. Data on the response of symptoms to treatment and the occurrence of side-effects may be not as 'hard' as endoscopically assessed 'healing' and 'relapse', but may be clinically more meaningful. Furthermore, in most recent trials, 'healing' and 'relapse' were poorly defined; important information on residual mucosal lesions after healing was often neglected.

Clinical Trials as Topic↗
PubMed1985

Intracamerally applied prostacyclin raises the intraocular pressure in the rabbit.

The effects of prostacyclin (PGI2) upon intraocular pressure and pupil size were examined in anaesthetized rabbits. Intracamerally applied PGI2 within the dosage range of 0.1 to 1.0/microgram led to an increase of the intraocular pressure (IOP) measured directly and continuously, and to a miosis. 6-oxo-PGF1 alpha, the product of hydrolysis of prostacyclin did not influence IOP or reaction of the pupil. Topical single doses of PGI2 of 4 to 80/micrograms on conjunctiva and cornea of the eye had no effect.

Animals↗
PubMed1984

[Enzymatic and scintigraphic determined infarct size: significance for left ventricular function following infarct].

In a prospective study, the relationship between extent and location of myocardial infarction and the resulting left ventricular dysfunction was assessed and the question asked, how well these parameters may be assessed non-invasively a few weeks after the acute event. One hundred and fifty survivors of a first myocardial infarction were studied in the acute stage by serial ECG and CPK recordings and 5 weeks later by thallium201-(Tl)-scintigraphy and radionuclide angiocardiography. Myocardial damage was assessed enzymatically (maximal CPK; CPKmax) in the acute phase and scintigraphically in the subacute phase using a Tl-score considering extent (in percent of total myocardium in each projection) and severity (decrease in thallium-uptake) of scintigraphic infarct defects. There were significant correlations between Tl-score and max. CPK (r = .69) as well as between Tl-score and left ventricular ejection fraction (LVEF) (r = .65; p less than .001 each), but this correlation was better for subgroups with anterior vs. inferior infarctions (r = -.68 vs. r = -.59; p less than or equal to .001 for each). Furthermore, LVEF could be predicted based on the Tl-score: 88% of patients with values less than 7 had an LVEF of greater than 45%, whereas 77% of patients with a thallium-score of more than 12 had an LVEF less than 45%. Reproducibility of the Tl-score assessed in 30 patients over 3 months was excellent (r = .96) with low variability between the two analyses (+/- 1.5). Thus, after a first myocardial infarction, a direct relationship between enzymatically and scintigraphically, assessed infarct size and LVEF could be demonstrated.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Xanthine oxidase in homogenized cow's milk and Oster's hypothesis: a review].

Oster has postulated that the enzyme xanthine oxidase in homogenized cow's milk is the cause of myocardial infarction and angina pectoris. This enzyme may be absorbed by ingestion, especially of the small particles of the fat globules, and then carried by lymph streams to the arterial vascular system, where it is deposited into the myocardium. Then it destroys the aldehydes liberated from the cell membrane-based plasmalogens. This results in the intimal damage to the cell membranes of the arterial intima and the myocardium and ultimately in the development of typical atherosclerotic lesions in the arteries. The presented review is a critical approach to this hypothesis. The following factors are discussed: - the influence of conditions prevailing in the intestine and the stomach on the activity of the xanthine oxidase in milk, - the possibility of this enzyme being absorbed in the intestine, - the formation of antibodies against absorbed xanthine oxidase and - the behaviour of xanthine oxidase administered intravenously. Compared with present knowledge, this theory gives little evidence only.

Absorption↗
PubMed1979

[Effect of 1,25-dihydroxycholecalciferol in renal osteopathy].

9 patients with advanced renal failure and renal osteodystrophy documented by iliac crest biopsy were treated with 1,25-dihydroxycholecalciferol (average dose 0.53 micrograms per day) for 6 months. Under 1,25-DHCC there was a statistically significant increase in serum calcium and decrease in serum alkaline phosphatase and immune parathyroid hormone. Histomorphometric evaluation of posttreatment bone biopsies showed reduction of osteoclastic resorption and endosteal fibrosis. Osteoid volume decreased in most cases. In 3 patients with predominant fibroosteoclasia, bone turnover practically normalized. Bone mineral content of the radius (photoabsorptiometry) did not change with treatment. Transient hypercalcemia occurred in 5 patients and was easily corrected by adjustment of 1,25-DHCC dosage.

Alkaline Phosphatase↗
PubMed1978

[Harmlessness to human health of the mold cultures used in cheesemaking].

Mould cultures are used for the manufacture of soft and blue cheese. The report deals with the present stage of knowledge of the question of mycotoxin-producers in mould cultures used for cheesemaking. The PR-toxin was isolated repeatedly from Penicillium roqueforti strains which were incubated on special media, but also from P. roqueforti cultures used for cheese manufacture. However, cheese ripening conditions do not favor the production of this toxin. Other catabolites from P. roqueforti such als roquefortine and isofumigaclavine have been found in cheese, but there is not much known about their toxic effect. No cancerogenic mycotoxins have been discovered in these types of cheese, except alfatoxin M1, which might however originate from contaminated milk. It must be concluded that the occurrence of tumors after feeding of a pure P. camemberti var. candidum culture is due to the effect of mycotoxins. On the other hand, further animal experiments with various mould culture stains used for cheesemaking have not confirmed these findings. On the basis of the literature consulted it may be said that the use of mould cultures for cheesemaking does not involve any risk for human health, that means it is toxicologically harmless.

Aflatoxins↗