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Biomedical subjects

R Sikora

Publications and source records attributed to R Sikora.

7 recordsLinked to original sources

[Angiography of the a. pudenda and its branches in erectile dysfunction. A modified angiographic technic and optimized use of vasodilator substances].

A new simplified technique for evaluating the internal pudendal artery and the penile vessels is described using a new catheter configuration with a very short 90 degrees-angled tip. In 30 consecutive patients, a superselective catheterisation of the internal pudendal artery was achieved in 93%. To improve visualisation of the penile arteries, the selective intraarterial application of 0.2 mg nitroglycerin in addition to the mandatory intracavernous injection of papaverin or prostaglandin E1 has proved to be of value. Examination of the blood blow velocity in the dorsal penile artery with Doppler ultrasound 2 minutes after intra-arterial application of 0.2 mg nitroclyerin showed a mean elevation of the Doppler amplitude by the factor 2.4 (range 0.4-9). With regard to the maximal increase of the blood velocity (range 1-6 minutes), a high interindividual difference was observed.

Arteries

[Reflectory stimulation of the pudendal nerve in dynamic pharmaco-cavernosometry].

A prospective study was performed in 20 patients to assess the impact of vibratory glans stimulation on the course and results of dynamic pharmaco-cavernosography and cavernosometry. An intracorporeal pressure rise was achieved with lower amounts of saline when stimulation was applied and in some cases could not be provoked by saline infusion without glans stimulation. False-positive diagnoses of diffuse venous leakage could thus be eliminated. The data presented in this paper confirm the need for stimulation of the pudendal reflex arch to achieve physiological conditions. The simplicity of the procedure and the minimal time requirement suggest its clinical routine application of vibratory glans stimulation during cavernosography and cavernosometry.

Erectile Dysfunction

[Imaging of penile vascular anastomoses using color-coded Doppler ultrasound: comparison with CW Doppler ultrasound and clinical aspects].

In fourteen patients undergoing surgical revascularization (11 with Hauri's, three with Virag's anastomosis) because of erectile dysfunction, the patency of vascular anastomosis was evaluated and visualized by color-coded-Doppler sonography (CCDS). Results were compared with continuous-wave Doppler (CWD) and clinical data. CCDS proved to be superior to CWD with regard to assessment of flow in the penile vessels and to applicability. Strength and direction of flow can be judged visually. Therefore, the nature of the imaged vessel (artery or vein, deep or dorsal artery) can be differentiated. There is a good correlation of CCDS and CWD in their evaluation of the patency of the anastomosis. CCDS showed higher accuracy in detecting deep cavernosal arteries.

Adult

[Microsurgical treatment for erectile impotence].

Using strict selection criteria, peripheral microsurgical revascularization was performed in 23 of 180 patients with erectile dysfunction (seen between February 1987 and December 1988). Average age of the 23 men was 51.8 (44-59) years. In 14 patients, the epigastric artery was transposed end-to-side to a side-to-side anastomosis between the dorsal artery and vein of the penis, while in two a piece of inferior epigastric vein was interposed. In the other seven patients an end-to-side anastomosis was constructed between the inferior epigastric artery and the deep dorsal vein of the penis. After three months, 19 of 20 patients who were followed-up had regular intercourse without intracavernous administration of drugs, after six months 15 of 17, after one year 11 of 14. In two patients irreversible thromboses of the anastomoses occurred when anticoagulant administration, required postoperatively, had been discontinued. The results indicate that with careful selection microsurgical treatment can achieve good results.

Anastomosis, Surgical

The value of magnetic resonance imaging at 1.5 T in the evaluation of the scrotal content.

50 patients with a broad variety of scrotal disorders were evaluated in form of a prospective study by high-resolution scrotal sonography and magnetic resonance imaging at 1.5 T with high-resolution surface coils. Basic anatomic correlations to normal structures of the scrotum were studied in 4 fresh cadaver testicles without pathology. Magnetic resonance imaging is sensitive and specific, but time-consuming and expensive.

Genital Diseases, Male

[Selective microsurgical therapy in vascular-induced erectile impotence].

Patients with erectile dysfunction should be subjected to a complex and complete diagnostic procedure, including selective pharmaco-phalloangiography and dynamic pharmacocavernosonography only when SKAT has failed and after the exclusion of neurological disorders. Patients being offered these invasive procedures should be highly motivated and willing to undergo surgical correction of the vascular origin of their erectile impotence. If peripheral vascular occlusive disease is found affecting the pelvic arteries, the best operative technique must be selected. In our opinion, this decision should be made intraoperatively after visualization of the dissected dorsal penile vessels. Use of the Doppler probe can be extremely helpful during the operation. Intraoperative findings on the degree of arteriosclerosis and arterial flow can differ from those allowed by preoperative diagnostic procedures. Penile erectile function was restored in seven of nine patients after penile revascularization performed under microsurgical conditions. We used the operative methods described by Virag and Hauri, applying our own modification of the Hauri procedure in two patients. With careful selection of patients and methods it should be possible to resolve individual patients' problems with peripheral occlusion, even though the exact hemodynamic pathology remains obscure.

Adult

The contingent negative variation during a memory retrieval task.

Evoked potentials were recorded from the human scalp during performance of a memory retrieval task modeled after a paradigm originated by Sternberg (1966). Subjects were required to decide whether a probe digit was contained in a series of one to four target digits presented a few seconds before. The amplitude of the contingent negative variation (CNV) preceding the probe digit and the speed of CNV resolution after the probe varied as a function of target set size. CNV amplitude was greatest when the set size was one. The smaller the set size, the more positive the evoked potential 300 msec after the probe, regardless of whether a motor response was required.

Adult