Biomedical subjects
Publications and source records attributed to R Sneppe.
The authors describe the further modifications made to the MSR-UCL cochlear implant since its creation in September 85, i.e. the transformation of the MSR-UCL monocanal apparatus into a bicanal implant, and the isolation of the pick-up from the amplifier. The technical and audiophonological advantages of these new adjustments are brought into evidence by the authors.
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This experiment suggests the following points: 1. Erythrocytes in control patients and in atherosclerosis patients seem to have a variable grade of affinity for adenosine and for plasma glucose. This variable grade seems to fix the level of the adenosine triphosphate (ATP) reserves and induces the erythrocytes' deformability. 2. The drop in the level of ATP reserves that induces the poor deformability of the erythrocytes in atherosclerosis patients would appear to be caused by two consecutive shortages: first a shortage that seems to be related to a deficiency of erythrocyte adenosine as the ATP shortage disappears with dipyridamole treatment and then a shortage induced by the lack of erythrocyte glucose and suppressed by the addition of ticlopidine to the dipyridamole treatment.
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We describe our experience with monocanal cochlear implants, which began in 1984 with a view to rehabilitation in severe bilateral deafness. This article describes two types of implant (Prelco and MSR-UCL), criteria of patient selection, surgical aspects pre- and postoperative evaluation setting by group, re-education aspects, and evolution test with quantitative values.
This study demonstrates the presence of PGI2 in blood and its influence on platelet retention tests, possibly by the intermediate of a releasing system in the columns, which is followed by a proximate recuperation on the erythrocyte sites after the passage. The presence of prostacyclin on the erythrocyte sites seems to depend upon the red cell deformability in relation to the good condition of their erythrocyte ATP reserve. The load of the erythrocyte sites increases with the daily dose of dipyridamole. The maximum load of the sites appears to be reached with a daily dose of dipyridamole 450 mg. Approximately 10% of the atherosclerosis patients who have been treated by dipyridamole keep their platelet hyperaggregability and their abnormally lowered prostacyclin level.
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A study of the dispersion of an alternative electrical field by a physical model, and its application in the control of unicanal extra-cochlear implant is discussed. The authors think that this method is indispensable for an objective control of the correct function of the extra-cochlear implant.
Our choice of a unicanal extracochlear implant is characterized by a reasonable attitude and simplicity. Simplicity and reason, because the already existing experiments show that in the field of cochlear implants there is no correlation a priori between the satisfaction of the research worker developing a complex electronic system in the laboratory and the satisfaction of the patient benefiting from such a system. Furthermore, the extracochlear implant respects and conserves the anatomical structure of the cochlea. It does not compromise future interventions. A replacement could be carried out in the future should a more perfected system be invented. The latter argument is particularly useful if a child is being considered for an implant. All patients with implants benefit from the following results: the satisfaction of hearing their own voice again, a better control of the voice (loudness and intensity), comprehension is facilitated (lip reading and noise perception), end of the sensation of isolation. The first results obtained are very encouraging. We find it most essential to continue our work in the same manner and with an inter-University working group (GRIC). The standardisation of results of the various teams involved seems to be imperative. We conclude by the following: At the present state of our knowledge, the unicanal extracochlear implant seems to be a reasonable solution and a realistic approach in the rehabilitation of total bilateral deafness.
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Explore the source record for details and available documents.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.