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Biomedical subjects

R Soler

Publications and source records attributed to R Soler.

At least 19 recordsLinked to original sources

MR imaging in inferior vena cava thrombosis.

PURPOSE: To prospectively evaluate the efficacy of MR imaging in inferior vena cava (IVC) thrombosis; to differentiate acute from non-acute thrombus, and to identify the presence of changes in the morphology and signal intensity during medical treatment. METHODS AND MATERIALS: Seventeen patients with suspected IVC thrombosis underwent 30 MR examinations. The IVC thromboses were subdivided into two groups (acute and non-acute) according to onset of clinical symptoms. MR imaging of the IVC was analyzed and when an IVC thrombus was identified, a qualitative and quantitative assessment of the thrombus on spin-echo sequences with magnitude and phase reconstruction was performed to evaluate the relationship between signal intensity and the time elapse since the onset of clinical symptoms. Venography and/or CT scan proof was available in all cases. RESULTS: IVC thrombus was correctly identified in 19 MR examinations which showed the size, localization and the degree of lysis during follow-up. No differences were found in the signal intensity of the thrombus related to time. The pattern of the signal intensity was homogeneous in six (86%) acute thrombus and heterogeneous in nine (75%) thrombus of more than 1 week duration. A significant statistical relationship (P < 0.01) existed between the thrombus age and differences in the pattern of signal intensity. CONCLUSIONS: MR imaging is accurate to assess the localization and size of IVC thrombus, similar to the imaging techniques of reference. In addition, MR also provides useful information about the age and the morphological variations of thrombus during medical treatment.

Acute Disease

Musculoskeletal amyloid disease: MRI features.

A case of arthropathy and soft tissue masses due to amyloid deposition in a patient with myeloma is reported. The radiologic and magnetic resonance findings of musculoskeletal amyloidosis are described. The amyloid masses show heterogeneous signal intensity, with a signal lower than muscle and intermingled areas of marked hyperintensity on T2-weighted images.

Amyloidosis

Multiple bile duct hamartomas: US, CT, and MR findings. A case report.

We report ultrasound, CT and MR findings in a patient with multiple bile duct hamartomas (BDH) which were associated with disseminated peritoneal leiomyomatosis, a coincidence not previously reported. At MR imaging, the multiple hepatic nodules of BDH were hypointense in T1-weighted images and moderately hyperintense in T2-weighted images, which is in agreement with the findings in the 2 previously reported cases examined with this modality.

Bile Duct Diseases

[Thoracic radiography in Pneumocystis carinii pneumonia in AIDS patients. Presentation forms and clinical course].

BACKGROUND: We intend to determine the frequency of the different radiographic findings of Pneumocystis carinii pneumonia in patients with AIDS. METHODS: We retrospectively review the chest roentgenograms of 30 patients at admission to the hospital (group I [n = 30]), at follow-up (group II [n = 30]) and after clinical recovery (group III [n = 15]). RESULTS: Diffuse bilateral interstitial disease was the most frequent radiographic finding at admission (76.6%) and at follow-up (60%). Atypical radiographic findings were: normal chest radiograph (group I [n = 3]), nodules (group I [n = 2], group II [n = 2], group III [n = 1]), thin wall cysts (group II [n = 1], group III [n = 1]), cavitated lesion (group II [n = 1], group III [n = 1]), pneumothorax (group II [n = 2], group III [n = 1]), pleural effusion (group III [n = 2]), asymmetrical distribution of the pulmonary lesion (group I [n = 2], group II [n = 3]) and predominant upper lobe involvement (group II [n = 1], group III [n = 1]). The atypical findings were greater during follow-up (group II [n = 33.3%], group III (46.6%) than at admission (group I [n = 23.4%]). CONCLUSIONS: It is important to know the frequency and multiplicity of the radiographic findings of Pneumocystis carinii pneumonia in order to establish the diagnosis and differentiation from other infectious diseases or other causes of pulmonary disease in patients with AIDS.

Acquired Immunodeficiency Syndrome

Clinical status of motoneuron disease does not correlate with serum neurotoxicity on cultured neurons.

To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients.

Adult

Renal allograft rupture: diagnostic role of ultrasound.

To evaluate the diagnostic role of ultrasound in spontaneous renal allograft rupture we reviewed 18 cases observed in our centre in 10 years. Ultrasound studies were performed immediately before surgery in 15 cases. Renal allograft rupture occurred during the first 3 weeks after transplantation in 17 cases (94%). Clinical findings were consistent with previous reports. The diagnosis was confirmed by surgical exploration in 17 cases, and by necropsy in the remaining one. Nine patients were treated by corsetage and eight by graft nephrectomy, while one patient died before surgery. Acute rejection was present in nine cases, and severe acute tubular necrosis in five; no renal tissue was available for histological study in four patients. On ultrasound examination, perirenal haematoma was the most frequent finding, while subcapsular/intrarenal haematoma or findings suggesting rejection or urinary tract obstruction were less frequently observed. In six cases, disruption of the white linear echoes of the capsule of the graft could be seen; this finding has not been described previously. Ultrasound has a definite role in presurgical evaluation of suspected renal transplant rupture.

Adolescent

[A difficult diagnosis].

We describe the case of a patient suffering from relapsing abdominal pain and vomiting over 4 years, in whom various radiological and endoscopic examinations remained normal. CT scan and MRI eventually showed a mesenteric mass corresponding to metastasis of an ileal carcinoid; this tumor was diagnosed only at laparotomy as well as his mesenteric and hepatic metastases. The different localization and clinical manifestations of carcinoid tumours as well as the difficulties of radiological diagnosis of tumours of the small bowel are mentioned; the diagnostic value of sonography. CT-scan and MRI in the diagnosis of hepatic metastasis is discussed.

Abdominal Pain

Case report 693: Schneckenbecken dysplasia.

Three siblings with SBD from consangineous parents are reported. The prenatal diagnosis of a short-limbed form of dwarfism was made by ultrasonography and the final diagnosis in the index case by radiography, demonstrating a short-limbed, platyspondylic dwarf with a snail-like configuration of the ilium and vertebral bodies, flat on AP and round on lateral view. The histological examination showed a generalized, severe disturbance of cartilage formation with marked hypercellularity of proliferating and resting zones, reduction of intercellular matrix, and shortening of the irregular columns of proliferating cartilage. The ultramicroscopic findings were nonspecific. This is the first report of SBD after the original description, bringing the total to 14 cases in 5 families. The correct radiological diagnosis and the differential diagnosis, in particular thanatophoric dysplasia, are essential for genetic counselling and obstetrical guidance of families affected with this autosomal recessive dysplasia.

Dwarfism

[The bone manifestations in 94 cases of sarcoidosis].

94 patients diagnosed as having sarcoidosis were studied in Galicia in order to evaluate the frequency of bone manifestations, as well as to analyse the clinical and radiological features. Bone lesions were found in 10 patients (10.6%) with a median age of 47.4 years, the predominant sex being female in this group (70%). The lesions were of two types: a) osteolytic on metacarpal (4 cases), nasal bones (1 case), sacrum (1 case), femur (1 case); b) osteosclerosis on femur and fibula (1 case), acrosclerosis (3 cases), metacarpal (1 case). The first lesions were associated to chronic types of sarcoidosis with skin and lung involvements. The second lesions were associated to a sub-acute type of Löfgren. We highlight the behaviour of both types of bone lesions and comment on the physiopathology of the sclerotic lesions.

Age Factors

Periportal-peripancreatic tuberculous adenitis. US and CT findings.

We present ultrasound (US) and computed tomography (CT) findings in 7 patients with periportal and peripancreatic tuberculous adenitis. In US scans, hypoechoic adenopathies were found in 6 patients while in the other one a hypoechoic, poorly marginated mass was seen. CT studies showed hypodense (25-35 HU) enlarged lymph nodes with immediate postcontrast peripheral rim enhancement in 3 patients. An infiltrating inhomogeneous mass was present in other patient and soft tissue density lobulated masses were found in delayed postcontrast scans of 2 patients. The US findings are of no help in distinguishing tuberculosis from other causes of adenitis. The CT appearance has been variable and only the hypodense nodes with peripheral enhancement in postcontrast scans are suggestive of this entity.

Adult

Retractile mesenteritis involving the colon: barium enema, sonographic, and CT findings.

Retractile mesenteritis is a rare disorder characterized by either focal or diffuse thickening of the mesentery due to chronic inflammation and fibrosis. Six cases are reported in which stenosis of the colon, an uncommon complication of retractile mesenteritis, was the predominant radiologic finding. Diagnosis was suggested by the tapered, serrated appearance of the stenotic segment on barium enema complemented by the findings on sonography and CT.

Adult

MR findings in hereditary spherocytosis.

The magnetic resonance findings of intrathoracic extramedullary hematopoiesis associated with bone marrow reconversion, and reticuloendothelial hemosiderosis in a 50-years-old are reported. Radiologic finding of extramedullary hematopoiesis was the first step to the diagnosis of previously unknown hereditary spherocytosis.

Bone Marrow