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R Spanedda

Publications and source records attributed to R Spanedda.

At least 37 records · Page 2Linked to original sources
PubMed1986

Involvement of chromosomes 12 and 14 in the cutaneous stage of mycosis fungoides: cytogenetic evidence for a multistep pathogenesis of the disease.

Cytogenetic studies were performed on the cells of bone marrow, peripheral blood, and skin tumor biopsies from a patient with mycosis fungoides at an early stage. Chromosome abnormalities were detected in 100% of the cells harvested from the cutaneous specimen, whereas the cells of the bone marrow and blood were karyotypically normal. Three related clones, showing increasing cytogenetic complexity, were found. Chromosome #12 was abnormal in all metaphases, and an abnormal 14q chromosome was present in a minority of cells belonging to the most complex emerging subclone. These data, along with the findings of important signs of chromosome imbalance, suggest a polyphasic evolution of this chronic T lymphoproliferative disease.

Chromosomes, Human, 13-15↗
PubMed1985

Cytogenetically distinct leukemic cell lines displaying in vitro specific proliferative and differentiation capacities may account for early disease relapse in the blast phase of CML.

The cytogenetic features and the proliferative and differentiation capabilities of blast cell fractions purified on a density gradient were studied in one patient with chronic myeloid leukemia (CML) in blast crisis, both at the emergence and at relapse of the disease. The results show that relapse was due to the appearance of a new leukemic cell line that was characterized by peculiar chromosomal, growth, and differentiation features, which seemingly accounted for early refractoriness to therapy and disease progression.

Adult↗
PubMed1985

[Abdominal ultrasonography in the staging and follow-up of malignant lymphomas].

During the period September 1980-June 1984, abdominal US was performed by the authors on 103 patients with confirmed malignant lymphomas. The results indicate US has accuracy comparable to that of lymphography for lymph node enlargement; furthermore, US has the added advantages of being able to demonstrate mesenteric, renal hilar and other abdominal lymph nodes that are not commonly filled with contrast medium during lymphography. For these reasons, US is now frequently used in the diagnosis and staging of malignant lymphomas as well as for following up the results of therapy.(US = ultrasonography)

Abdomen↗
PubMed1984

[Comparison between traditional skeletal radiography and total body bone scintigraphy in the diagnosis of multiple myeloma].

28 patients with multiple myeloma were examined by skeletal x-ray and 99Tcm-diphosphonate bone scan. Using both techniques, a total of 70 myelomatous bone lesions was found in 13 (46,5%) of the 28 patients: 69 bone lesions were detected by radiography and 33 by radionuclide imaging. Results indicate that x-ray is superior to bone scan, approximately twice, in detecting myeloma-related bone lesions. The low sensitivity of bone scan in myeloma can most likely be explained by the particular nature of myelomatous bone lesions. Multiple myeloma is almost always osteolytic, with very little new bone formation and extensive osteoclast activity related to osteoclast activating factor, whereas skeletal uptake of 99Tcm-diphosphonate seems to be related mainly to osteoblastic process. An exception to this general finding is the rib fractures, in which the two methods are equally reliable. These findings suggest that radiography is the method of first choice in obtaining a skeletal survey in patients with multiple myeloma.

Bone and Bones↗
PubMed1983

[Value and limits of echography and abdominal lymphography in malignant lymphomas].

Diagnostic results obtained by echography and lymphography in the study of abdominal lymphoglandular involvement in patients with lymphomas are compared. The data indicate that while lymphography is more revealing, the two examinations should be used together in staging. Echography, on the other hand, should be used for long-term surveillance, once the lymphographic contrast medium has been absorbed.

Female↗
PubMed1983

Primary malignant fibrous histiocytoma of the sigmoid colon: a case report.

This paper presents a case of malignant fibrous histiocytoma localized in the sigmoid colon with multiple metastases in the right lobe of the liver and describes the pathological and microscopic aspects, clinical course and characteristics. The primary localization in the sigmoid colon is extremely rare, this being only the second case reported.

Histiocytoma, Benign Fibrous↗
PubMed1982

[Skeletal changes in non-Hodgkin lymphoma].

140 patients affected by non-Hodgkin lymphoma (NHL) are performed by the A. Skeletal involvement of metastatic nature is observed in 14 of these (10%). Only the aggressive lymphomas have radiographic bone disseminations. At beginning of disease no patient has interested by bone changes. The most frequent roentgenographic finding observed by the A. include high incidence of osteolityc lesions: in particularly, pattern so called "permeative" is present in 35.6% of cases. Osteosclerotic and mixed manifestations were much less commonly observed (7,2% respectively). Periosteal reactions is not observed in any cases. The value of roentgen skeletal investigation in diagnosis, staging and therapy of NHL is discussed by the A.

Adult↗
PubMed1977

Acute myelomomocytic leukemia terminating in histiocytic medullary reticulosis: cytochemical, cytogenetic and electron microscopic studies.

A case of acute myelomonocytic leukemia terminating in histiocytic medullary reticulosis is reported. The evolution of a single cellular clone presenting with progressive change of the morphological features of the leukemic cells towards more anaplastic elements endowed with prominent phagocytic properties is suggested on the basis of both cytochemical and chromosomal data. The histiocytic nature of the malignant proliferating cells and platelet phagocytosis has been confirmed by electron microscopic investigation. The main pathogenetic explanations of the evolutionary patterns of the disease are discussed with relation to: a) involvement of a common stem cell giving rise to different proliferative patterns of cells in a multiphasic sequence; b) release of dysplastic platelets and defective erythrocytes with massive sequestration by histioid phagocytic cells; and c) coexistence of two different disorders.

Blood Cell Count↗