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Biomedical subjects

R Spiesser

Publications and source records attributed to R Spiesser.

15 recordsLinked to original sources
PubMed1990

Aldactazine/captopril combination, safe and effective in mild to moderate systemic hypertension: report on a multicenter study of 967 patients.

The safety and efficacy of a thiazide/potassium-sparing diuretic and an angiotensin-converting enzyme inhibitor used concomitantly was evaluated in a large, multicenter study. Aldactazine was administered alone for 2 months, after which time captopril was added in those whose blood pressure had not normalized (332 patients). At the end of the 6-month study, control of blood pressure was achieved in 88% of the patients with one or the other regimen. No clinically significant changes were recorded for a number of biologic parameters. Specifically, there was 1 case of hyperkalemia (6 mmol/liter), a very low incidence of hypotension (1.6%), and a low rate of adverse effects. Therefore, such a combination could provide important therapeutic benefits in hypertensive patients.

Adolescent↗
PubMed1987

[Plasma concentration of noradrenaline in essential arterial hypertension].

Plasma norepinephrine concentrations after supine rest and after standing were measured by high-pressure liquid chromatography with electrochemical detection in 49 normotensive controls and in 79 patients with essential hypertension. Twenty-nine hypertensive patients were not treated for hypertension. In normotensive subjects--but not in hypertensive patients--supine plasma norepinephrine levels increased significantly with age. No significant difference in supine plasma norepinephrine levels was found between hypertensive patients (NE = 0.28 +/- 0.16 microgram/l, n = 79 and NE = 0.28 +/- 0.14 microgram/l, n = 29) and normotensive subjects (NE = 0.30 +/- 0.13 microgram/l). When expressed as percentage, the rise in norepinephrine levels when standing was greater in hypertensive patients (127.4 +/- 77.4%, n = 79 and 122.6 +/- 65.6%, n = 29) than in normotensive subjects (93.2 +/- 60.3%). When patients and controls aged less than 40 years were compared, similar results were obtained. Supine plasma norepinephrine levels do not support the theory that sympathetic system activity is enhanced in essential hypertension.

Adolescent↗
PubMed1983

[Prognostic impact of renal manifestations of necrotizing angeitis. Apropos of 24 cases].

To analyze the prognostic significance of renal involvement, data from 24 cases of necrotizing angeitis, with renal involvement in 16, is studied. Associated disorders are described. Patients are divided into four groups: acute renal failure, progressive renal failure, renal involvement with normal renal function, and no renal involvement. Acute renal failure et onset appears to be a poor prognosis factor in necrotizing angeitis. Progressive renal failure seems to have no bearing on the short-term and medium-term vital prognosis. The value of plasma exchange therapy in these indications is discussed.

Acute Kidney Injury↗
PubMed1983

[Glomerular lesions renal transplant patients excluding recurrence of glomerulopathy].

The authors report their experience with glomerular lesions after renal transplantation, but exclude recurrent glomerulonephritis. Fourteen cases (3 membranous glomerulopathies and eleven allograft glomerulopathies) are discussed in relation to 98 recipients of 105 renal allografts. Two patients with membranous glomerulopathy had HBs antigen in their serum. A poor graft prognosis is observed in 2 of 3 patients. Among eleven recipients who presented with allograft glomerulopathy, two groups are clearly defined with very different graft prognosis. The severity of the vascular lesions was the sole difference between these two groups. The possible physiopathologic mechanisms of allograft glomerulopathy are discussed. It is worth noting that the role of vesico-ureteric reflux is not a prominent feature of this study.

Adult↗