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R Stach

Publications and source records attributed to R Stach.

28 records · Page 2Linked to original sources
PubMed1976

The effect on cortical mirror foci produced by ouabain of gamma-aminobutyric acid, dopamine and haloperidol injected into the rabbit caudate nucleus.

Epileptiform activity is inhibited by injection of dopamine, and potentiated by injections of haloperidol into the caudate nucleus. gamma-Aminobutyric acid (GABA) initially potentiates, and shortly after that inhibits the epileptoform activity in the cortex. The authors discuss a possibility of combined treatment of seizure states with dopamine-mimetic and GABA-mimetic agents.

Aminobutyrates↗
PubMedDate not supplied

The effect of naloxone on carbachol-induced seizures in the caudate nucleus and in the hippocampus.

Intravenous injection of 1 or 10 mg/kg of naloxone did not affect the bioelectrical and behavioral epileptiform activity induced by carbachol application into the dorsal hippocampus in freely moving chronically implanted rabbits. In contrast, naloxone given intravenously (10 mg/kg) or intracaudally (2 micrograms) prolonged the duration and increased the amplitude of bioelectrical epileptiform activity induced by intracaudal carbachol application. The above results indicate that endogenous opioid peptides may inhibit seizure activity in the caudate nucleus.

Animals↗
PubMedDate not supplied

The effects of antidepressant drugs on the seizures kindled from the rabbit amygdala.

The effects of tricyclic antidepressants; imipramine and doxepin, and of new antidepressants; mianserin, danitracen, trazodone, viloxazine and zimelidine, on seizures kindled from the rabbit amygdala were examined. Behavioral and bioelectrical seizures were kindled by a repeated daily stimulation of unilateral amygdala with a low intensity electric current (120 microamperemeter, 1 msec, 50Hz). The following parameters of kindled seizures were analyzed: 1-intensity of behavioral seizures according to a 6-point scale, 2-duration of behavioral seizures, 3-duration of bioelectrical (EEG) seizure activity. Only imipramine inhibited all parameters of kindled seizures. Doxepin, mianserin, danitracen and trazodone affected only two parameters. Zimelidine did not induce any changes of kindled seizure, and viloxazine prolonged duration of the bioelectrical seizure activity. It is likely that inhibition of seizures kindled from the rabbit amygdala is due to noradrenaline stimulating or serotonin inhibiting properties of the drugs, but independent of the antidepressive activity.

Amygdala↗