Sequence of three introns in the chick ovalbumin gene.
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Animals↗
Biomedical subjects
R Staden
Publications and source records attributed to R Staden.
Nucleotide sequence of bacteriophage G4 DNA.
The 5,577 nucleotide long sequence of bacteriophage G4 DNA has been determined using the 'plus and minus' and chain termination methods of DNA sequencing. This sequence has been compared with that of the closely related bacteriophage phiX174 (refs 1, 55). In the coding regions there is an average of 33.1% nucleotide sequence differences between the two genomes, but the distribution of these changes is not random and the sequence of some genes is more conserved than others. There is less sequence similarity between the untranslated intergenic regions of G4 and phiX174, but despite this the sequences of the J/F, F/G and H/A untranslated spaces in both genomes have similar sized hairpin loops, which may be related to their function.
Bacteriophages↗
Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene.
A short partial sequence homology is present at all intron-exon junctions, or splice points, in the chick ovalbumin gene; it is probably a signal for a splicing enzyme. The significance of the junction sequences for splicing is discussed. We find no evidence of strong Watson-Crick base pairing between adjacent junctions.
Animals↗
Further procedures for sequence analysis by computer.
A previous paper(1) described programs for sequence data handling and analysis by computer. The facilities of this basic set are extended by further easily used programs.
Base Sequence↗
Sequence data handling by computer.
The speed of the new DNA sequencing techniques has created a need for computer programs to handle the data produced. This paper describes simple programs designed specifically for use by people with little or no computer experience. The programs are for use on small computers and provide facilities for storage, editing and analysis of both DNA and amino acid sequences. A magnetic tape containing these programs is available on request.
Amino Acid Sequence↗