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Biomedical subjects

R Staud

Publications and source records attributed to R Staud.

24 records · Page 2Linked to original sources
PubMed1980

[Effect of pirenzepine and atropine on the transmural gastric mucosal potential difference (author's transl)].

The transmural gastric mucosal potential difference (PD) measured by endoscopy has proved to be a good parameter in evaluating dose dependent effects of drugs. In 43 volunteers the maximum increases of the PD taken from the gastric juice were found after 30 mg pirenzepine and 0,5 and I mg atropin within 16 minutes. There was a significant difference between 20 and 30 mg pirenzepin. The dose of 20 mg pirenzepin seems to be insufficient to induce a maximum increase of PD in each individual.

Atropine↗
PubMed1980

[Significance of the correction of aspirated volumes for the results of the secretin-pancreozymin test (author's transl)].

A group of 123 patients without manifestation of an impaired pancreatic function was studied with the secretin-pancreozymin test (group I). In 54 patients (group II) the correction of aspirated volumes during the secretin-pancreozymin test was performed with polyethylene glycol 4000 (PEG) as a marker substance. The mean values of volume-, bicarbonate- and enzyme secretion showed higher levels in 7 of 9 parameters in group II. The recovery rate of polyethylene glycol in group II (median: 92% indicated, why there was no marked difference between both groups. If the secretin-pancreozymin test is performed according to the above method the correction of aspirated volumes becomes negligible for the determination of normal values. However single results of the secretin-pancreozymin test, especially pathological ones, can only be based on the correction of the aspirate.

Adult↗
PubMed1975

Excretion of methylproscillaridin in patients with a biliary fistula.

Four patients with a biliary fistula received 0.5 mg 3H-methylproscillaridin as a single oral dose. 55% of the dose was excreted in bile, 16% in urine and 3% in faeces. More than 60% of the radioactivity excreted in bile and urine appeared within the first 24 hours. 78% of the radioactivity in bile consisted of CHCl3-insoluble metabolites of methylproscillaridin, incubation of which with beta-glucuronidase led to splitting off glucuronic acid from almost 80%. Methylproscillaridin can be regarded as the principal conjugated compound. TLC-separation of CHCl3-soluble compounds from bile showed identical running of radioactivity with methylproscillaridin, proscillaridin and scillarenin and three unknown metabolites P1, P2, and P3. In urine the CHCl3-soluble fraction averaged 16% to 34% of the total amount and was identified as methylproscillaridin, proscillaridin, scillarenin, P2 and P3. The relative composition of the total radioactivity in faeces amounted to 77% methylproscillardidin, 4% scillarenin and 12% polar metabolites.

Aged↗
PubMed1975

Metabolism and excretion of methylproscillaridin by man.

0.5 mg 3H-proscillaridin-4-methylether was administered orally to 5 healthy males. Maximum plasma levels of total radioactivity were reached after one to two hours. In two subjects a second peak was observed between 6 and 12 hours. The plasma half life of total radioactivity was 51 hours. 20% and 56% respectively of the dose were eliminated in urine and faeces during the following 7 days. 55% of the total radioactivity in plasma, 80% in urine and 20% in faeces consisted of CHC13-insoluble compounds. 50-60% of the latter in plasma and urine could be hydrolysed by beta-glucuronidase. More than 90% of the split products were identified as conjugates of methylproscillaridin. TLC-separation of the CHC13-soluble fractions of plasma and urine yielded two unidentified metabolites, P2 and P3, as the main compounds, besides methylproscillaridin, proscillaridin and scillarenin. In faeces more than 90% of the non-polar fraction was identified as methylproscillaridin. Shortly after administration of 3H-methylproscillaridin, the radioactivity in plasma consisted mainly of CHC13-insoluble conjugates and of the metabolite P2.

Adult↗