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Biomedical subjects

R Steiger

Publications and source records attributed to R Steiger.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Text processing in pathology. Setup and content of text data for autopsy reports].

Elaboration of a text catalogue of the most important terms and findings is essential for computerized reports to be effectively introduced in pathology. Such a catalogue must be constructed so, that the majority of reports or findings, respectively, can be accommodated or generated. Structure and content of a text catalogue are illustrated with examples for autopsy reports.

Autopsy↗
PubMed1982

The disposition of free and liposomally encapsulated antimalarial primaquine in mice.

Plasma clearance, urinary excretion and tissue distribution of radiolabeled free (FPQ) and liposome-entrapped Primaquine (LPQ) in mice were monitored for 2 hr following intravenous administration. FPQ is eliminated very rapidly from the plasma and excreted predominantly in the urine, probably largely in a metabolized form. In decreasing order of magnitude, pronounced accumulation of label occurs in the liver, kidneys, lungs and skeletal muscle. Less than 1 per cent of the total initial dose is recovered in other tissues. Partial erythrocytic sequestration results in drug levels higher and more persistent in blood cells than in the plasma. Compared to the free drug form, Primaquine entrapped within negatively charged liposomes of the cholesterol-rich multilamellar type exhibits a prolonged plasmatic half-life and, within the observation period, excretion is 8-fold reduced. Liver accumulation of label is doubled, accounting for close to 50% of the injected dose; splenic uptake is tripled, while accumulation in the lungs, kidneys, heart and brain is drastically reduced. These differences in pharmacodynamic behaviour may explain why liposomal entrapment leads to diminished acute Primaquine toxicity.

Animals↗
PubMed1982

[Experience with artificial urine diversion in children by means of an ileum bladder on the basis of 22 cases (author's transl)].

We report on the problem of artificial urine diversion in children on the basis of 22 cases in which we carried out cutaneous uretero-ileostomies according to Bricker. One patient died as a consequence of an pre-existing renal insufficiency. We were able to monitor all other 21 patients subsequently. The patients were questioned on general development and social integration; stoma and the surrounding skin were assessed locally. We examined renal function by means of laboratory parameters and the isotope nephrogram. In summary, it can be said that few problems arise in respect of care and social integration, and that lasting kidney damage can also be reduced by strict monitoring and long-term antibiotic treatment.

Anti-Bacterial Agents↗
PubMed1981

Development of new derivatives of primaquine by association with lysosomotropic carriers.

On the basis of the drug-carrier concept of chemotherapy, we entrapped primaquine in liposomes, and linked it to an amino acid (leucine), and to peptides (alanyl-leucine and alanyl-leucyl-alanyl-leucyl) as intermediate steps in the synthesis of covalent primaquine-glycoprotein conjugates that would be selectively recognized by hepatocytes.The therapeutic activity of these compounds was tested in mice infected with sporozoites of Plasmodium berghei. Causal prophylatic cures were obtained after a single intravenous injection of primaquine-liposomes (60-70 mg of primaquine/kg of bodyweight) and lower doses (35 mg of primaquine/kg of bodyweight) of ala-leu-primaquine and ala-leu-ala-leu-primaquine.The administration of such high doses was only possible as a result of the decreased toxicity of primaquine when entrapped in liposomes and confirms the validity of the drug-carrier concept for the treatment of malarial infections. The improved chemotherapeutic index of ala-leu-primaquine and ala-leu-ala-leu-primaquine resulted from their decreased toxicity and increased chemotherapeutic activity. These peptide derivatives are probably acting as pro-drugs of primaquine.

Animals↗