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Biomedical subjects

R Stern-Padovan

Publications and source records attributed to R Stern-Padovan.

13 recordsLinked to original sources
PubMed2006

Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis.

We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.

Adolescent↗
PubMed2006

Conservative surgical treatment of low-grade urothelial carcinoma in the renal allograft recipient: a case report.

Development of urothelial carcinoma in a renal allograft is rare. We report the case of 52-year-old male patient who developed chronic renal failure secondary to Balkan endemic nephropathy and underwent renal allotransplantation. The patient who developed low-grade pTa urothelial carcinoma in the left contracted kidney at 3 years after transplantation and underwent nephroureterectomy. Three years later, the same neoplastic process was observed in the renal allograft. Preoperative estimation for allograft tumor recurrence and progression included percutaneous tumor biopsy followed by cytopathological, histological, and cytogenetic analysis. Cytopathology revealed well-differentiated urothelial tumor cells. Histopathologic analysis showed low-grade urothelial carcinoma. Cytogenetic examination demonstrated that the tumor originated from the recipient suggesting a low malignant potential of carcinoma. Based on these findings, we decided to perform a right-side nephroureterectomy and graft-sparing procedure, which resulted in preservation of allograft function. In this report we discussed the prognostic factors, which are the basis for rational therapeutic approaches in these patients.

Balkan Nephropathy↗
PubMed2005

[Rupture of the spleen and acute pancreatitis after ESWL therapy: a rare complication].

INTRODUCTION: ESWL is a safe and efficient method in the therapy of urolithiasis which, however, is not free of complications. CASE REPORT: ESWL was performed in a 54-year-old patient with a stone of 18 mm in size located in one of the upper calyces of the left kidney. Several hours after the ambulatory ESWL treatment the patient was admitted to the emergency room with strong pain in the left lumbar region and the upper abdomen. During examination low blood pressure, tachycardia and low Hb levels were found. Ultrasound and CAT scans revealed a subcapsular rupture of the spleen. Surgery was indicated, and a laparotomy with splenectomy was performed. Ten days after surgery the patient developed acute pancreatitis which was treated conservatively with success. CONCLUSIONS: Although ESWL is a safe method in the treatment of urinary stones with a relatively small number of complications, rare complications like ruptures of the spleen have to be considered. Special attention should be given to patients with kidney stones in the left upper calyces, pathological growth of the spleen, and accompanying diseases such as chronic heart failure or hypertension. In such patients ESWL should not be performed on an outpatient basis.

Acute Disease↗
PubMed1998

Eyebrow keyhole approach in vascular neurosurgery.

The authors review their experience in the surgery of intracranial aneurysms via an eyebrow keyhole approach. The eyebrow keyhole approach presumes a skin incision in the lateral two-thirds of the eyebrow followed by small supraorbital craniotomy (15 x 25 mm). Using this approach and an intraoperative endoscope for better visualisation of the aneurysmal neck, the authors operated on thirty-seven patients with forty intracranial aneurysms. There was no mortality, postoperative recovery was fast, and the cosmetic effect was excellent. Advantages and possibilities of this approach are discussed and results are presented. The authors recommend this approach as a minimal invasive surgery procedure in the treatment of intracranial aneurysms. When performed by experienced vascular neurosurgeons this approach is neither more difficult for the surgeon nor more dangerous for the patient than any other standard craniotomy procedure. According to the authors' present results, surgery of intracranial aneurysm via an eyebrow keyhole approach is the method of choice when performed by an experienced vascular neurosurgeon.

Adolescent↗
PubMed1980

Histologic changes in the ageing spiral tract.

To investigate the influence of ageing on the morphology of the bottom of the internal auditory meatus, we analysed 150 undecalcified pyramids of human temporal bones. In most of the histologic sections examined, we found pointed bony spicules in the region of the spiral tract. These develop from layers of active and resting osteoid, reach their final morphologic shape in the fourth decade of life and then protrude into the internal auditory meatus, compressing the cochlear nerve fibers.

Adolescent↗
PubMed1980

Holographic investigations of the human tibiofibular interosseous membrane.

The interosseous membrane contributes to the function of the fibula by neutralizing the freedom of movement in the upper tibiofibular joint and by keeping the fibula from being passive. The main role of the membrane is indicated by its shearing capacity. As a result of dislocation and bending of the tibia (during axial loading), and the passivity of the fibula, the membrane slides in the direction of the leg's axis causing the zone of maximal shearing in its upper central part. This is the principal zone of strain and divides the upper portion of the membrane into the tibial and fibular area. Damage of the upper part of the membrane, perpendicular to the main fiber bundles, causes an irregular deformation of the talus, while complete damage of the membrane unburdens the fibula in load transference by more than 30%. The interosseous membrane is important in the normal function of the lower leg by maintaining the axis of balanced loading of the foot.

Biomechanical Phenomena↗