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Biomedical subjects

R Straight

Publications and source records attributed to R Straight.

9 recordsLinked to original sources
PubMed1997

Intraoperative phototherapy: a comparative study of intravenous and topical photofrin II and aminolevulinic acid.

This study compares the systemic and topical application of photofrin II and aminolevulinic acid as an intraoperative adjuvant therapy in the C3H mouse radiation-induced fibrosarcoma model. Dose-development and time-dependent studies were first conducted followed by intraoperative phototherapy studies with photofrin II and aminolevulinic acid. Study results clearly show that intraoperative phototherapy after aminolevulinic acid topical application is significantly more effective than treatment with photofrin II given intravenously or topically (p < 0.05) in this animal tumor model. The concept of topical application of photosensitizers and the rationale for intraoperative adjuvant phototherapy are discussed.

Aminolevulinic Acid↗
PubMed1990

Comparison of photosensitizers in saline and liposomes for tumor photodynamic therapy and skin phototoxicity.

The uptake and distribution, skin phototoxicity, and direct tumor ablative potential of three porphyrin photosensitizers: hematoporphyrin derivative (HPD), dye hematoporphyrin ether (DHE), polyhematoporphyrin esters (PHE), and of Rhodamine-123 (Rh-123) have been studied in the AJ-CR inbred albino female mouse implanted with C-1300 neuroblastoma. Photosensitizer delivery was studied using saline and liposome carriers. The ratio of tumor uptake of the porphyrin compounds compared to the tumor-bed musculature and skin was favorable with both saline and liposome delivery. Rhodamine-123 precipitated in saline but was delivered effectively throughout the body in liposomes. There was no selective uptake by tumor cells of Rh-123 in this tumor model. Skin phototoxicity with the porphyrin compounds was mildly decreased using liposomes carriers while Rh-123 demonstrated no skin phototoxicity. DHE had the greatest tumoricidal effect among the porphyrin compounds. PHE has the potential of increased effect due to the ability to use higher light dosages in the activation of this porphyrin. Rhodamine-123 had no tumor effect in this animal model. Clinical implications of phototherapy with these four compounds are addressed.

Animals↗