Biomedical subjects

R Strzelecki

Publications and source records attributed to R Strzelecki.

At least 19 recordsLinked to original sources

PubMed1997

Selective expansion of gammadelta T cells among liver-derived lymphocytes of AIDS patients with disseminated Mycobacterium avium complex infection.

The aim of this study was to investigate a potential expansion of gammadelta T cells in AIDS patients in response to disseminated infection with Mycobacterium avium complex. Liver-derived lymphocytes and peripheral blood lymphocytes were obtained from 5 AIDS patients with disseminated Mycobacterium avium complex infection and 10 HIV-infected patients without mycobacterial disease. Control patients included 14 HIV-negative patients without bacterial disease and 4 HIV-negative patients with disseminated Mycobacterium tuberculosis infection. The percentage of gammadelta T cells among CD3+ T lymphocytes was determined by flow cytometry. gammadelta T cells were markedly enhanced in liver biopsies but not among peripheral blood lymphocytes of AIDS patients with disseminated M. avium complex infection (median liver gammadelta/CD3: 26%) as compared to HIV-infected control patients without mycobacterial disease (median liver gammadelta/CD3: 2.3%; P < 0,005). Disseminated infection with M. tuberculosis in HIV-negative patients leads to a similar expansion of gammadelta T cells among liver-derived CD3+ lymphocytes (median gammadelta/CD3: 15.5%) as compared to control patients without mycobacterial disease (median gammadelta/CD3: 2.15%; P < 0,001).

AIDS-Related Opportunistic Infections↗

PubMed1997

Enhanced expression of activation antigens HLA-DR and CD69 on gamma delta T cells but impaired interleukin-2-induced upregulation in HIV-1 infection.

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Acquired Immunodeficiency Syndrome↗

PubMed1996

[Sepsis--generalized infection. The treatment of adults based on personal observations].

Basing on the own experience, the authors discuss causative treatment of sepsis, mainly of unknown etiology. Emphasis is on the depression of immunological system in the acute phase of the disease. Therefore, a combined treatment with 2, often 3 or even 4 bacterial antibiotics is recommended, together with passive immunotherapy, and in certain cases surgical removal of the infection foci.

Adult↗

PubMed1996

[Sepsis--a generalized infection. Etiopathogenetic, diagnostic and clinical problems in adults based on personal experiences].

Etiopathogenetic, diagnostic, and clinical problems seen in the adult patients with sepsis have been discussed. An emphasis is on the diagnostic problems in an early stage of infection as well as bacteriological findings. The authors stress that sepsis usually develops in patients with depressed immunological system.

Adolescent↗

PubMed1994

[Bacterial meningitis in patients with sepsis syndrome].

The authors discuss problems connected with diagnosis, management and treatment of bacterial meningitis among patients with the sepsis syndrome. Considering secondary organ changes bacterial meningitis belongs to the severest one and as a life-threathing sequel of sepsis demands immediate use of proper casual treatment. The authors show the therapeutic difficulties in this group of patients particularly when the etiological organism is unknown. They discuss this problems and present their own schemes of tretment. They indicate the value of passive immunotherapy and surgical removal of the primary source of infection. They emphasize final result depends on secondary organ changes, age, immunity of patient and the kind of etiological agent.

Escherichia coli↗

PubMed1993

[Tubercular meningitis and encephalitis in adults--own experience].

Diagnostic, clinical and therapeutical problems of tuberculous meningitis and encephalitis have been discussed on a basis of clinical observation of 67 patients. In the early phase of disease the diagnosis is based on clinical parameters and results of cerebrospinal fluid examinations. Authors suggest a shortage of time treatment under 12 months.

Adolescent↗

PubMed1991

[Etiology, clinical course, and the methods and results of the treatment of suppurative meningoencephalitis in adults--personal observations data].

The authors discuss problems connected with the clinical, aetiological diagnosis, methods and results of treatment of purulent meningoencephalitis in adults. The basis for the discussion were own experiences obtained during hospitalization of 578 patients in the period 1981-1990. As a results of this analysis the authors found that the organisms causing this disease most frequently were, as previously, Neisseria meningitidis and anaerobic Haemophilus influenzae were still highly unsatisfactory. Complete recovery was obtained in 73.3% of cases, 6.6% were discharged with various neurological sequelae, and 29.1% died. Cases of pneumococcal origin, frequent after cranial trauma, showed the most severe course, had the highest percent of psychoneurological complications and recurrences with the highest death rate.

Adolescent↗

PubMed1988