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Biomedical subjects

R Suzuki

Publications and source records attributed to R Suzuki.

At least 775 records · Page 43Linked to original sources
PubMed1977

Preclinical toxicological study of phosphonoacetic acid: determination in blood by selected ion monitoring.

Confirmed observations of the inhibition of oncogenic viruses by phosphonoacetic acid led to preclinical trials in animal model systems. Circulating phosphonoacetic acid was detected in the blood of mouse, rabbit and monkey after oral or subcutaneous administration of the drug. Phosphonoacetic acid is quantified in blood, after removing proteins and lipids, as the trimethylsilylated derivative, by monitoring the intensity of the protonated molecular ion and also that of phosphonopropionic acid (internal standard) using chemical ionization mass spectrometry combined with gas chromatography. The detection limit is 20 ng ml-1 when 0.2 ml serum is analyzed. A dosage of 230 mg kg-1 day-1 by continuous infusion is proposed for therapeutic trials in monkeys. This dose is well tolerated and results in slowly increasing blood levels of phosphonoacetic acid which reach a maximum of approximately 50 microgram ml-1 in a four day infusion, and decrease to 2 microgram ml-1 24 h after termination.

Animals↗
PubMed1976

Electrochemical neuron model.

1) A mathematical model for the behavior of passive iron in nitric acid, based on the electrochemical mechanisms, has been proposed. The model is capable of explaining several phenomena including threshold for activation, monostable property, periodic activation, propagation of activation, and threshold for propagation. Furthermore, the mathematical model predicts that the electrochemical active line has a specific propagated waveform and velocity of propagation. 2) By using iron-silver junctions in nitric acid, we could form a McCulloch-Pitts type neuron model. Also we could show the occurrence of reverberation on a net of iron wires in nitric acid.

Electrochemistry↗
PubMed1975

Ontogenetic expression of larval and adult hemoglobin phenotypes in the intergeneric salmonid hybrids.

Ontogeny of the hemoglobins of Honmasu (Oncorhynchus rhodurus, HXH),brook trout (Salvelinus fontinalis, BXB) and their reciprocal hybrids (HXB and BXH) was examined electrophoretically as well as spectrophotometrically. All of these fish have electrophoretically distinct larval and adult type hemoglobins and the transition from one type to the other occurred early during post-hatching development. In the case of larval hemoglobins, the electrophoretic pattern of a hybrid, BXH, resembled that of the maternal parent, brook trout (BXB), while the hemoglobin of the reciprocal hybrid, HXB, differed markedly from that of the maternal parent, Honmasu (HXH), in that it possesses a diffuse pattern. Spectrophotometric examinations indicated that this was mostly methemoglobin. Adult type hemoglobins at more advanced stages of both hybrids were electrophoretically resolved into the parental hemoglobins. However, no "hybrid" hemoglobins were detected. Because there was abnormal hemoglobin formation in the larval erythrocytes (erythrocytes L) of the HXB hybrid, and then normal hemoglobin synthesis in the adult erythrocytes (erythrocytes A) of the same fish at later developmental stages, it appears that the paternal effects upon the hemoglobin differed in these two erythroid cell lines of the developing trout.

Animals↗