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R T Adamian

Publications and source records attributed to R T Adamian.

18 recordsLinked to original sources
PubMed1998

[Effect of live tularemia vaccine on some parameters of immune and non-specific antitumor resistance in endometrial cancer patients during combined therapy and later].

The levels of T-system lymphocytes, macrophageal transformation of mononuclears and phagocytic activity of blood neutrophils were assayed in 194 patients with endometrial tumors, stage I-IV, (FIGO, 1988), 10-15 days after surgery, a subsequent course of telegammatherapy and 2-3 years after treatment. Ninety-seven patients of the study group were challenged by immunization with a live tularemia vaccine (LTV) 15-20 days before surgery, while the same number of controls were not. The study was randomized. Pre-operative LTV immunization showed an immunoprotective effect at all stages of combined treatment (surgery + telegammatherapy) given for endometrial carcinoma. Moreover, all said indices came back to normal in the study group 2-3 years after treatment. After surgery alone (standard uterine extirpation or with adnexa), controls with malignancies at the same stages revealed a significant decrease in the indices which fell further after radiotherapy. In the latter group, the indices came back to initial values which were below the norm.

Bacterial Vaccines↗
PubMed1997

[Immediate and long-term results of combined therapy of patients with endometrial neoplasms depending on the effect of counter-suppression of blood lymphocytes].

The short-term (wound healing) and end-results (relapse and metastasis frequency, duration of relapse-free survival and 2-, 3- and 5-year survival) of combined treatment (surgery + gamma therapy) of 97 patients with endometrial carcinoma (stage I-II and stage III-IV) (FIGO, 1988) versus the effect of preoperative counter-suppression of blood lymphocytes were investigated. Both short-term and end-results appeared to be much better in patients showing the counter-suppression effect; they were much worse in patients who revealed the effect prior to combined therapy, and still worse--in cases of inverse effect involving enhanced suppression. It is suggested that the effect of blood lymphocyte counter-suppression before combined treatment is a factor of favorable prognosis in patients with endometrial carcinoma.

Combined Modality Therapy↗
PubMed1997

[Adjuvant immunotherapy for patients with cancer of corpus uteri].

A randomized study was carried out of the efficacy of a new procedure of adjuvant immunotherapy for cancer of corpus uteri in conjunction with anticoagulant treatment. Ninety-seven patients (76-stage I-II and 21-stage III-IV) were inoculated tularemia booster (TB) and received fibrinolysin, pelentan and aspirin 15-20 days before combined treatment including uterine extirpation or extirpation with adnexa followed by telegammatherapy. Two groups of identical numbers of patients with an identical distribution of tumor progression stage were used as controls. No vaccination was carried out in one of them while TB inoculation was performed without anticoagulants in the other. A higher effectiveness of immunostimulation accompanied by anticoagulant administration was registered on the basis of the short-term (wound healing) and end results (relapse and metastasis frequency, duration of relapse-free survival and 2-, 3- and 5-year survival).

Anticoagulants↗
PubMed1996

[Evaluation of immunotherapy in breast cancer (stage III-IV) and in cancer of the corpus uteri (stage I-III)].

A new clinically-tested procedure of adjuvant immunotherapy carried out in conjunction with anticoagulant treatment is discussed. Application of said method has significantly improved the short-term and end results of treatment of inoperable cases of breast cancer, stage III-IV, receiving chemotherapy and patients with cancer of corpus uteri, stage I-III, receiving combined therapy plus radiation.

Anticoagulants↗
PubMed1995

[The effect of tularemia vaccine on some parameters of immune and non-specific anti-tumor resistance in patients with endometrial tumors].

On days 15-20 after immunization of patients suffering from endometrial tumors with tularemia live vaccine, a significant increase was registered in T-cell population of the immune system, macrophagal transformation of mononuclears and phagocyticity of blood neutrophiles which are generally reduced in stages III-IV. The study group included cases of all tumor stages. Said indices reached normal levels in stage I-II only.

Bacterial Vaccines↗
PubMed1991

[Clinico-morphological signs of hormone-producing ovarian tumors].

Apparent signs of hormonal activity were observed in 65.3% of patients with hormone-producing ovarian tumors of different histology. Feminization was evident in 69.1% of cases of granulosa-stromal cell tumors: it was most often seen in patients with mixed theca-granulosa cell tumors (86.2%) but was least frequent in those with Brenner's tumor (22.2%). The occurrence of proliferative lesions of the uterus such as hyperplasia of the endometrium, cervical canal polyps and uterine myoma (81.8%) was higher in patients with granulosa-stromal cell tumors, too, the highest rate being observed for cases of mixed theca-granulosa cell tumors (93.1%) whereas the lowest--for patients with Brenner's tumor (27.8%). Various clinical signs of masculinization were most often seen in cases of androblastoma (79.2%) whereas the proliferative disorders in that group were rare (12.5%). As a result, the authors placed mixed theca-granulosa cell, theca cell, granulosa cell tumors and Brenner's tumor in the order of decreasing feminizing activity. In the granulosa-stromal cell tumor subgroup, masculinization was most often observed in granulosa cell tumor patients (12.1%).

Brenner Tumor↗
PubMed1991

[The prognostic factors in patients with malignant granulosa-theca cell tumors of the ovaries].

The extent of tumor, as revealed by surgery in 113 primary patients with malignant granulosa-stromal cell tumors of the ovaries (granulosa cell--77, theca cell--17 and mixed theca-granulosa cell tumors--19 patients), was analysed versus duration of disease, laterality of tumor and patient age. Factors which were significantly or as a marked tendency associated with stage III and IV of disease and thus suggested poor prognosis were identified.

Age Factors↗
PubMed1991

[Hyperplastic processes and endometrial cancer in patients with hormone-producing ovarian tumors].

Status of the endometrium was assessed in 357 patients with hormone-producing tumors of the ovaries of major histological types such as theca cell (161 cases), granulosa cell (123) and mixed theca-granulosa cell tumors (22) as well as androblastoma (23) and Brenner's tumor (28 patients). Hyperplastic lesions of the endometrium, cancer included, were established in 250 (74.8%) patients with feminizing hormone-producing tumors whereas androblastoma patients showed either atrophic or normal endometrium (78.3% cases) and failed to reveal atypical hyperplasia or cancer of that site.

Brenner Tumor↗
PubMed1989

[Immunosuppressive activity of the blood serum of patients with cancer of the corpus uteri].

In 40 patients with endometrial carcinoma of I-IV stage reaction of suppression of migration and adhesion of leukocytes (RSML and RSAL) in response to antigen prepared from the same tumour and in the presence of autoserum of blood of these patients, was studied. The index of antibody-forming cells (IAFC) and percentage of rosette-producing cells (RPC) in mice spleen after their infusion before immunization by sheep erythrocytes blood serum of the mentioned patients were also investigated. It was ascertained, that in all cases with using of autoserum of patients with endometrial carcinoma, especially on late stages, significant diminution of positive RSML and RSAL and decrease of IAFC and RPC take place. It was concluded that blood serum of patients with endometrial carcinoma gives evidence of immunosuppressive activity at late stages of the process.

Animals↗
PubMed1988

[Differential diagnosis of malignant forms of hormonally-active tumors of the ovary].

Case histories of 427 patients with main histotypes of hormone-producing tumors of the ovaries (201--theca-cell, 177--granulosa-cell, 28--mixed theca-granulosa-cell and 21--virilizing) were analyzed. The problem of differential diagnosis of malignant forms of these tumors by methods of clinical examination was studied. Major statistically significant clinical signs of malignancy of hormone-producing tumors of the ovaries--extension of abdomen and abdominal pain, relatively short duration of case history, bilateral lesions, large size of sessile tuberculous tumors, high level of ascites, especially hemorrhagic one, and comparatively young age of patients--were established.

Adenoma↗
PubMed1987

[Realization of reproductive function and hormonally active ovarian tumors].

Reproductive function was studied in 438 women with practically all histotypes of hormone-producing tumors of the ovaries (141-theca cell, 97-granulosa cell, 14-mixed theca-granulosa cell, 11-masculinizing and 26-Brenner tumors). The said function was reduced in 141 reproductive patients (48.8%). It was shown that hormone producing tumors of the ovary do not cause reproductive function to decline. Conversely, it was infrequent or no births in the young age that could have been a factor of tumorigenesis.

Adenoma↗
PubMed1987

[Fibrocervicohysteroscopy in the diagnosis of cancer of the endometrium and cervical canal].

Fibrocervicohysteroscopy was performed in 152 patients in whom cancer of the endometrium or cervical canal was suspected. The said pathology was detected in 33 cases (21.7%). The basic advantages of the procedure described are as follows: (I) atraumatic nature assured by flexible operating part of the fibroscope, (2) clear visualization of the uterine cavity areas which are difficult of access, even in cases of pronounced organic lesions and deformity of the uterus, and (3) possibility of repeated biopsy from any part of the uterine mucosa.

Adult↗
PubMed1981

[Malignancy of hormonally active ovarian tumors].

401 cases of hormone-producing tumors of the ovary were studied (190 theca-cell, 169--granulose cell, 25--mixed thecagranulosa cell and 17--virilising tumors). Histological diagnosis, clinical stage and end results of their treatment were compared. Theca-granulosa cell tumor is considered to be the most malignant form of these neoplasms. Pure theca-cell tumor proved to be benign in most cases. Of special interest is a high percentage of patients being cured at stage 1 (FIGO classification) of neoplastic process, that stands, in the authors' opinion, in close relationship with comparatively good results obtained in these patients.

Adenoma↗
PubMed1981

[Brenner tumor].

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Adult↗
PubMedDate not supplied

[The principles of the microsurgical plastic repair of the plantar surface of the foot].

An analysis of long-term results of microsurgical plasty of defects of the plantar surface of the foot of different genesis is presented. 64 microsurgical flaps were transplanted. The main long-term complication of the method is the formation of rubs and trophic ulcers in 37% of patients after the restoration of support on the transplanted flap. Causes of the complications in question were established and methods of surgical treatment are proposed.

Adolescent↗