Ocular disease caused by nematodes.
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Biomedical subjects
Publications and source records attributed to R T Bellows.
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The traditional theories of senile cataract formation have one common denominator. Nearly all the agents and factors heretofore ascribed as causes of cataract formation have some element involving a potent crosslinking agent. The factors considered in this paper include endocrine and metabolic factors, involutional and hereditary influences, nutritional deficiencies, osmotic changes, ionizing radiation, ultraviolet light, altered capsular permeability, and the cumulative effects of subliminal exposure to noxae. Throughout life, the human lens is exposed to the influence of numerous potent crosslinking agents and it now appears that the cumulative actions of crosslinkage is the chief cause of senile cataracts. If this theory proves to be correct, it will offer some hope that cataract formation can be retarded by agents which counteract crosslinkage or by avoidance of excessive exposure to crosslinking agents.
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A previously reported well standardized tensile strength model in rabbits was sued in order to answer whether or not monofilament nylon does in fact delay corneal wound healing in general, and in particular, in corneal grafts. The tensile strength of penetrating keratoplasty wounds closed with either 10-0 running monofilament nylon or 8-0 interrupted black silk was measured in rabbits. The tensile strength of wounds closed with either suture was comparable in all groups. The advantages of 10-0 nylon in corneal transplantation and cataract extraction was presented. In addition, the assumption that the tensile strength of linear central wounds parallels that of a circular trephine wound was proven to be correct.
The theory of crosslinkage as a cause of aging of all living organic tissues has withstood the test of time. Nearly all the past theories of senile cataract formation contain elements involving a potent crosslinking agent. Therefore crosslinkage may now be recognized as the common denominator in past theories of senile cataracts. This paper proposes that crosslinkage is the mechanism for senile cataract formation.
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