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Biomedical subjects

R T Brodell

Publications and source records attributed to R T Brodell.

15 recordsLinked to original sources

The treatment of benign sebaceous hyperplasia with the topical application of bichloracetic acid.

Sebaceous hyperplasia is a benign lesion that occurs commonly on the face of older individuals. A variety of treatment options have been described, including oral isotretinoin, electrodesiccation, CO2 laser surgery, cryosurgery, and shave excision with curettage. Problems have been noted with these approaches. These techniques are more complex, less effective, require more time, or are more likely to scar than the procedure we describe. The treatment of sebaceous hyperplasia with bichloracetic acid is described with results presented after treatment of our first 20 patients.

Administration, Topical

Office dermatologic testing: the KOH preparation.

A potassium hydroxide preparation is used to confirm the diagnosis of a superficial fungal skin infection. Adding black or blue-black ink to the potassium hydroxide solution highlights fungal organisms and distinguishes them from surrounding cellular debris.

Biopsy

Office dermatologic testing: the scabies preparation.

Patients with scabies may present with urticarial, eczematous or excoriated papules, eczematous patches or, occasionally, nodules. It is often difficult to differentiate scabies from eczema, folliculitis, drug eruption or lichen planus. The classically described burrows are often not seen. The scabies preparation, as described in this article, will aid in making the proper diagnosis.

Clinical Protocols

Office dermatologic testing: the Tzanck preparation.

Whether a vesicobullous disease is intraepidermal or subepidermal is often difficult to determine from the clinical examination. The Tzanck preparation can provide clues that aid in the diagnosis of a number of diseases. It is particularly helpful in confirming the diagnosis of herpes infection. This article outlines the materials and steps for performing this valuable test.

Azure Stains

Red tattoo reactions: treatment with the carbon dioxide laser.

Cutaneous reactions to red tattoo pigment occurred in two patients who developed erythema, swelling, and severe pruritus in the area of red coloration within their tattoos. Carbon dioxide (CO2) laser vaporization of the red portions of the tattoos led to complete resolution of symptoms with an excellent cosmetic result and preservation of the tattoo design. A step-by-step guide to the use of the CO2 laser for this treatment is described.

Adult

Tinea versicolor of the face in black children in a temperate region.

Tinea versicolor is a common superficial fungal infection that typically affects young adults in warm, humid climates. We describe two young black children in the temperate northeastern Ohio area with tinea versicolor limited to the face. The occurrence of tinea versicolor on the face is unusual, as is its appearance before puberty. The mycologic and pathophysiologic characteristics of tinea versicolor infection are discussed, and several hypothesis are offered to explain the presence of tinea versicolor in these patients.

Black People

Cutaneous lesions of lymphomatoid granulomatosis.

Lymphomatoid granulomatosis is a rare multisystem disease involving the lungs, skin, and nervous system. The cutaneous disease may be the presenting complaint. A case with nodular and annular infiltrated lesions is reported to encourage the inclusion of lymphomatoid granulomatosis in the differential diagnosis of similar lesions. Prompt diagnosis and early long-term treatment with cyclophosphamide and prednisone can lead to prolonged remissions of this disease. If relapse occurs, prompt treatment with the same regimen may again induce a remission.

Adult

Cutaneous pseudolymphomas.

Pseudolymphomas of the skin form a heterogeneous and complex group of disorders. A deep knowledge of the different entities is required to make a correct diagnosis and to administer proper treatment. The group includes a wide range of disorders from banal lymphocytic infiltrations to diseases with guarded prognosis. The clinical and histologic characteristic of each disorder are discussed in the context of new diagnostic methods.

Diagnosis, Differential

Borderline and atypical melanocytic lesions.

The importance of correct diagnosis of melanocytic lesions cannot be overemphasized. Prognosis and treatment of these patients are based on the pathological diagnosis. The superficial melanocytic lesions are difficult to diagnose and pose frequent diagnostic dilemmas. Benign, dysplastic, and early malignant melanocytic tumors can be diagnosed based on more or less characteristic features. The pattern of growth, cytology of the melanocytes, and the lymphocytic, and stromal reaction are the histological cornerstones for diagnosis. Another diagnostic problem is the so called "borderline" melanocytic neoplasm. These lesions are characterized by a distinctive nodular growth phase. The difficulty in distinguishing some of these neoplasms from atypical fibroxanthoma is emphasized.

Carcinoma in Situ