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Biomedical subjects

R T Greyson-Fleg

Publications and source records attributed to R T Greyson-Fleg.

5 recordsLinked to original sources

Osteogenesis imperfecta and campomelic dysplasia: difficulties in prenatal diagnosis.

The classic features of osteogenesis imperfecta and campomelic dysplasia typically are so specific that these two forms of skeletal dysplasia are among the few that can be diagnosed in the second trimester of pregnancy. We report a series of seven examples of osteogenesis imperfecta and one example of campomelic dwarfism to illustrate the difficulty of differentiating these two disorders in utero. The prenatal sonographic findings in three of the osteogenesis imperfecta cases mimicked campomelic dwarfism, whereas the case of campomelic dwarfism was antenatally diagnosed as osteogenesis imperfecta.

Adolescent↗

Fibrosarcoma in a patient with scleroderma.

Malignancies have been described in association with various connective tissue disorders. While such associations may be relatively common in some disorders, such as polymyositis, the relationship between scleroderma and malignancy is more controversial. A case of fibrosarcoma of the tibia in a patient with scleroderma is presented, with correlation of conventional radiography, computed tomography, and histopathology.

Adult↗

Post-traumatic osteochondroma.

Osteochondromas can arise as primary, spontaneous tumors of bone or in previously irradiated bone. We report a patient who developed an osteochondroma of bone which arose secondary to previous trauma. This has not previously been reported.

Adolescent↗

Computed tomography findings in gastrointestinal involvement by opportunistic organisms in acquired immune deficiency syndrome.

The computed tomography findings in two cases of gastrointestinal superinfection by opportunistic organisms in acquired immune deficiency syndrome are presented. Findings included thickening of the mucosal folds and the bowel wall in the small intestine and colon associated with cytomegalovirus and cryptosporidiosis. These cases indicate that it is important to look carefully at the gastrointestinal tract when performing computed tomography in this group of patients. Unsuspected bowel pathology may be demonstrated, or disease may be confirmed in clinically suspected cases.

Acquired Immunodeficiency Syndrome↗