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Biomedical subjects

R T Guindi

Publications and source records attributed to R T Guindi.

8 recordsLinked to original sources
PubMed1990

Penicillamine in systemic sclerosis: a reappraisal.

In a 36-month prospective trial 21 patients with systemic sclerosis (diffuse systemic sclerosis 16 patients and 5 subjects with limited cutaneous subtype) were treated with D-penicillamine. In all patients with diffuse systemic sclerosis there was objective improvement. The degree and extent of skin involvement decreased significantly (p less than 0.001), whereas no objective improvement was noted in patients with limited cutaneous subtype. Further, no systemic progression of the disease was observed during the study period. Our results suggest that a prolonged treatment with D-penicillamine in small doses is not only beneficial and effective but also free of side-effects, if used at an earlier stage.

Adult↗
PubMed1990

Glucose metabolism and beta receptor function in atopic asthmatics.

Severe asthma and diabetes have been reported not to co-exist in the same patient. Various studies have attributed this to the possible association of asthma with hyperinsulinism, increased responsiveness to insulin or to beta-blockade. Previous studies have not addressed all these possible mechanisms in the same patient. In this prospective study, 7 atopic asthmatics and 7 age and sex-matched healthy controls underwent glucose, insulin and glucagon tolerance tests. The results showed no evidence of hyperinsulinism or increased responsiveness to insulin. Intravenous administration of glucagon, however, showed a lesser increase of glucose and insulin in asthmatics. Since glucagon has a beta-agonist effect on the liver and activates glycogenolysis and gluconeogenesis via beta-receptor stimulation and stimulates insulin secretion by activating adenylate cyclase of pancreatic beta-cells through beta-receptors, the results of glucagon tolerance test in our study may therefore suggest the presence of partial beta-blockade in atopic asthmatics.

Adult↗
PubMed1990

Pericardial tamponade and limited cutaneous systemic sclerosis (CREST syndrome)

A patient with limited cutaneous systemic sclerosis (ISSc) is described who presented with acute chest pain, dyspnoea and signs of cardiac tamponade requiring pericardiocentesis although the quantity of effusion was moderate. The haemodynamic data recorded from this patient suggested that pericardial fibrosis may be a major contributing predisposing factor to pericardial tamponade, while the cause of pericarditis and effusion remain obscure.

Cardiac Tamponade↗
PubMed1990

Association between HLA-DR antigens and rheumatoid arthritis in Arabs.

Eighty five Arab patients with classical and definite rheumatoid arthritis were typed to determine the prevalence of HLA A, B, C, and DR antigens. A significant increase in the prevalence of HLA-A10, B8, B21, and DR3 was found in comparison with a control population matched for age and sex. HLA-DR5 was significantly decreased in the patient group. The classical association of HLA-DR4 with rheumatoid arthritis could not be confirmed in the Arab patients resident in Kuwait, supporting reported observations in different ethnic groups of associations with HLA antigens other than HLA-DR4 and indicating a heterogeneous genetic susceptibility to rheumatoid arthritis.

Adult↗
PubMed1989

The haematocrit value in diabetic patients with ischaemic stroke.

During a 3-yr period, 238 patients with acute ischaemic stroke were admitted to the medical department of Mubarak teaching hospital, Kuwait. One hundred patients had diabetes, (42%), including 55 females, and 45 males. Compared with non-diabetics, no significant difference was found in age, sex, prevalence of hypertension, heart disease, atrial fibrillation, transient ischaemic attacks or in plasma cholesterol and triglycerides. Plasma glucose on admission was significantly higher in diabetics (14.6 +/- 5.7) compared with non-diabetics (6.1 +/- 1.2 mmol/l) p less than 0.0001. Haematocrit (HCT) was also significantly higher in diabetics (43.17 +/- 5.75) than in non-diabetics (41.20 +/- 5.85) p less than 0.046. Diabetics had higher mortality (21%) than non-diabetics (10%) p less than 0.05. Severe disability was also more frequent in diabetics (23%) than in non-diabetics (10.8%) p less than 0.05. Diabetic men had significantly higher HCT (45.7 +/- 5.2) than non-diabetic (43.1 +/- 4.1) p less than 0.04. Diabetic women had also higher HCT (41.1 +/- 6.2) than non-diabetic (38.8 +/- 5.8), but this was not statistically significant. Compared with age (+/- 2 yr) and sex matched diabetic patients with other clinical problems, diabetic stroke patients had significantly higher plasma glucose (14.6 +/- 5.7) than non-stroke patients (11.8 +/- 3.7 mmol/l) p less than 0.01. Hct was also significantly higher in diabetic stroke patients (43.17 +/- 5.75) compared with other diabetic patients (41.04 +/- 4.3) p less than 0.04.

Blood Glucose↗
PubMed1988

Polymyositis and hepatocellular carcinoma.

We report a patient with recent onset of acute polymyositis who was subsequently found to have a hepatocellular carcinoma, a rare uncommonly associated malignancy.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Histocompatibility antigens (A, B, C, and DR) in Arabs with rheumatoid arthritis.

Eighty-five Arab patients in Kuwait with classical and definite rheumatoid arthritis were typed to examine the frequency of HLA-A, B, C, and DR antigens. The results showed a significant increase in the frequency of HLA-A10, B8, B21, and DR3 antigens when compared to an age- and sex-matched control population. HLA-DR3 was present in 34 per cent of the patients compared with 2 per cent of the controls (p less than 0.001). The association of RA in the Arab population with HLA-DR3 rather than HLA-DR4 or HLA-DR1 as reported in other ethnic groups emphasizes further the complexity of the genetics of RA.

Arthritis, Rheumatoid↗