Five human sera with reaginic activity to a number of allergens were fractionated using anion exchange chromatography. In each serum, fractions which contained detectable IgG and no detectable IgA had capacity to fix to skin and subsequently elicit a P-K reaction. Four of these sera had reaginic activity about equally distributed between fractions containing only IgG and fractions containing mixtures of IgG and IgA. A fifth serum contained reaginic activity to crystalline bovine serum albumin (BSA) and most of the activity was associated with the fraction which contained only IgG. This serum was extensively studied using a variety of techniques and it was confirmed that most of the reagin to BSA in this serum was in those fractions containing only IgG. Since reaginic activity can no longer be considered a unique property of IgA the implications of finding antibody with reaginic qualities in immunoglobulins other than IgA are discussed.

Antibodies↗

PubMed1966

Dissecting popliteal cyst simulating thrombophlebitis.

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Aged↗

PubMedDate not supplied

Pirprofen and aspirin in rheumatoid arthritis: a double-blind comparison study.

A six-month, double-blind study was conducted to compare pirprofen (Rengasil), 800 mg per day, to aspirin, 3.6 Gm per day, in patients with active, definite, or classical rheumatoid arthritis. Data from 33 patients, 17 in the pirprofen group and 16 in the aspirin group, were analyzed for efficacy while data from 37 patients were analyzed for safety. In the pirprofen group, four of seven variables analyzed were significantly improved over baseline at the terminal visit; no statistically significant improvement was seen at the terminal visit in the aspirin group, although statistically significant improvement was achieved at a number of interim visits. Between-treatment comparisons indicated that pirprofen was statistically superior to aspirin with respect to the number of swollen joints at the terminal visit and average grip strength after six weeks of treatment. There were no serious signs of toxicity in either treatment group.

Anti-Inflammatory Agents↗