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Biomedical subjects

R T Rubin

Publications and source records attributed to R T Rubin.

175 records · Page 10Linked to original sources
PubMedDate not supplied

Secondary depression in panic disorder and agoraphobia. II. Dimensions of depressive symptomatology and their response to treatment.

Secondary depressive symptomatology in 435 subjects with panic disorder and phobic avoidance was studied before and after alprazolam treatment. No subject who had a primary affective disorder was included. Calculation of Hamilton Depression Rating Scale factor scores revealed that the agitation/anxiety, sleep disturbance, and somatization factors accounted for approximately 75% of the HAM-D total score; these all showed significant improvement with alprazolam treatment. There were few differences in dimensions of depressive symptomatology between those subjects with and those without major depression; the main difference was in the overall intensity of the depression.

Adolescent↗
PubMedDate not supplied

Psychological and physiological assessments on American hostages freed from captivity in Iran.

Medical evaluations of 52 Americans held hostage in Iran for 444 days included psychological testing and physiological measurements. Psychological testing utilized the Minnesota Multiphasic Personality Inventory (MMPI) and the 16 Personality Factor Questionnaire (16-PF) and focused on the stress management capabilities of the group upon their arrival at Wiesbaden, West Germany. Physiological testing utilized plasma and urinary cortisol along with plasma and urinary catecholamine levels to help document former hostages' stress responses following their release from captivity. Saliva cortisol and testosterone were measured over the first three hospital days to assess the group's psychophysiological recovery. Psychological testing indicated that the former hostages, as a group, were generally well defended, appearing to have endured their ordeal well. In contrast, plasma and saliva cortisol, urinary catecholamines, and saliva testosterone were seen to be highly elevated. These physiological measures appeared to reflect three strong affects: distress, anxiety, and elation. Saliva cortisol was the only physiological measurement that demonstrated a significant correlation with psychiatrists' ratings of the released hostages' psychological disturbance. Psychiatrists' disturbance ratings appeared to be a valid psychometric estimate, as adduced from their correlations with MMPI and 16-PF major scales.

Adult↗
PubMedDate not supplied

Biophysical membrane interactions of steroid hormones: a potential complementary mechanism of steroid action.

There is strong evidence to support the hypothesis that the rapid effects of steroids on neurons are membrane-mediated. Rapid steroid effects have been demonstrated in the absence of intracellular receptors, in the presence of RNA or protein synthesis inhibitors, and in response to steroids coupled to large proteins that block access to intracellular receptors. This study selectively reviewed the emerging body of evidence suggesting that steroids have multiple sites of cellular actions, and explored in depth one possible membrane-mediated mechanism of action, the membrane-intercalation model.

Biophysical Phenomena↗