PubMed Health⌕ Search

Biomedical subjects

R T Segraves

Publications and source records attributed to R T Segraves.

17 recordsLinked to original sources
PubMed1991

Effect of apomorphine on penile tumescence in men with psychogenic impotence.

In a double-blind study using physiological recording of penile tumescence, brachial subcutaneous apomorphine hydrochloride injections elicited penile erections in men with psychogenic impotence. This observation is compatible with the hypothesis of central dopaminergic involvement in human penile erection. Since apomorphine is believed to induce erections by its effect on brain monoamine pathways, apomorphine response may have diagnostic use in evaluating the etiology of erectile failure.

Apomorphine↗
PubMed1991

Hypoactive sexual desire disorder: prevalence and comorbidity in 906 subjects.

The frequency of hypoactive sexual desire disorder (HSDD) and the frequency of comorbidity of sexual disorders was recorded from a total population of 906 subjects studied in a multisite pharmaceutical study. Sixty-five percent had a primary diagnosis of HSDD, HSDD was far more common in females than male subjects. Males diagnosed with HSDD were significantly older than women diagnosed with HSDD. Approximately, 40% of the subjects with a primary diagnosis of HSDD had second diagnoses of arousal or orgasm disorders.

Cross-Sectional Studies↗
PubMed1990

Categorical and multi-axial diagnosis of male erectile disorder.

Diagnostic information was examined on 258 men with male erectile disorder in a multi-site study. Of the sample, 78% was diagnosed as having difficulty both in obtaining and maintaining erections; 20% had a secondary or tertiary diagnosis of hypoactive sexual desire disorder. There was minimal evidence that the multi-axial diagnostic system has advantages over the categorical DSM-III-R diagnosis of male erectile disorder.

Adult↗
PubMed1989

Effects of psychotropic drugs on human erection and ejaculation.

Evidence concerning pharmacological effects on human sexuality suggests that dopaminergic receptor activation may be associated with penile erection. Erection also appears to involve inhibition of alpha-adrenergic influences and beta-adrenergic stimulation plus the release of a noncholinergic vasodilator substance, possibly vasoactive intestinal peptide. Ejaculation appears to be mediated primarily by alpha-adrenergic fibers. Serotonergic neurotransmission may inhibit the ejaculatory reflex. An understanding of the neurobiological substrate of human sexuality may assist clinicians in choosing psychotropic agents with minimal adverse effects on sexual behavior and may also contribute to the development of pharmacological interventions for sexual difficulties.

Ejaculation↗
PubMed1988

Psychiatric drugs and inhibited female orgasm.

The available evidence concerning sexual side effects of psychiatric drugs suggests that inhibited female orgasm may be associated with the use of hetereocyclic antidepressants, monoamine oxidase inhibitors, benzodiazepines, and neuroleptics. Possible mechanisms of action including anticholinergic, alpha adrenergic blockade, and serotonergic effects are discussed.

Antidepressive Agents↗
PubMed1988

Sexual side-effects of psychiatric drugs.

Clinical case reports, clinical series, and a small number of controlled studies provide evidence that many commonly prescribed psychiatric drugs may have untoward effects on sexual function. Both heterocyclic antidepressants and monoamine oxidase inhibitors appear to be associated with ejaculatory impairment. Erectile dysfunction and retarded ejaculation have been associated with neuroleptics. Several benzodiazepines have been reported to interfere with ejaculation. This information has clear significance for the prescribing physician.

Anti-Anxiety Agents↗
PubMed1987

Use of sexual history to differentiate organic from psychogenic impotence.

The use of sexual symptomatology to differentiate psychogenic from organogenic impotence was studied. All patients were independently classified based on the evaluation of a minimum of one night of nocturnal penile tumescence recording, a sleep lab technician's rating of penile turgidity of erections, Doppler determination of penile blood flow, determination of serum prolactin and testosterone levels. Three aspects of symptomatology significantly discriminated the criterion groups. The single best predictor was the presence or absence of early morning erections as reported by the patient.

Diagnosis, Differential↗
PubMed1986

Psychiatric treatment of erectile dysfunction in urology outpatient clinic.

This study examined the feasibility of establishing a satellite psychiatry service in a urology outpatient clinic for the express purpose of engaging men with inhibited sexual excitement in psychiatric treatment. This approach appeared to be more successful as judged by complete referrals and symptom remission than referral to a psychiatry clinic.

Ambulatory Care↗
PubMed1978

Conjoint marital therapy: a cognitive behavioral model.

This article presents an integrated cognitive-behavioral model for conjoint therapy of chronic marital discord. The model is based on eight empirically testable hypotheses that are clinically relevant and integrate contributions from general systems theory, behavioral marital therapy, and psychoanalysis. Disproof of cognitive schemas for the perception of the opposite sex (transference reactions) is hypothesized to be a common therapeutic mechanism in the dissimilar models of marital therapy.

Adult↗
PubMed1976

Concurrent psychotherapy and behavior therapy. Treatment of psychoneurotic outpatients.

The feasibility and effects of treating psychoneurotic outpatients with concomitant but separate treatment programs of psychoanalytically oriented psychotherapy and behavior therapy was investigated in three cases, utilizing detailed clinical observations and questionnaire responses. The two treatment regimens appeared to have synergistic effects, and anticipated difficulties, such as a split therapeutic alliance, symptom substitution, or preciptious withdrawal from psychotherapy after symptom removal, did not occur. Although there was no evidence of symptom substitution after the behavioral removal of the "target symptom," both clinical observations and questionnaire responses indicated that successful behavior therapy had many unanticipated effects on the patient's nontarget behaviors and cognitions.

Adult↗
PubMed1976

Primary orgasmic dysfunction: essential treatment components.

In an attempt to determine the essential components of a successful treatment regime for primary orgasmic dysfunction, the principle treatment approaches are reviewed to elucidate the similarities in different programs which have reported similar outcome data. It is concluded that the systematic desensitization studies, the masturbatory training approaches, and the Reproductive Biology Research Foundation series are all effective treatment procedures. It appears that all three approaches employ graduated exposure to sexual stimuli plus some form of directive psychotherapy emphasizing interpersonal skills acquisition. These may be the essential treatment components.

Female↗