Biomedical subjects
Publications and source records attributed to R T Szymanowski.
Malignant change may occur in a pharyngo-esophageal diverticulum and although it is rare, a small number of cases has been reported. A similar case is reported here to contribute to the awareness of the existence of such an entity.
A 10-year-old boy with mixed bilateral hearing loss and unusual facies was found to have frontometaphyseal dysplasia. He has prominent supraorbital ridges, height-span disproportion, dental abnormalities, thick clavicles, pectus excavatum, winged scapulae, joint contractures, and generalized muscular underdevelopment. Roentgenograms show supraorbital hyperostosis, antegonial notching of the mandible, flared ilia, contraction of the midpelvis, flattened vertebrae, deformities of the ribs posteriorly, flared metaphyses of the long tubular bones, and greatly widened and elongated metacarpals, metatarsals, and phalanges. His mother has prominent supraorbital ridges, distinct scoliosis, contractures of the fifth fingers, and conductive hearing loss. She also has many of the roentgenographic features of frontometaphyseal dysplasia. Frontometaphyseal dysplasia in a mother and son strongly suggests a dominant mode of inheritance.
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Case histories of 47 patients with multiple head and neck neoplasms were reviewed at the Henry Ford Hospital. Data were obtained on the site of the malignancy and treatment program. Follow-up data have been good, utilizing clinic records. Several patients have had more than two malignancies of the head and neck, and one patient has just completed treatment for his fifth epidermoid carcinoma. The incidence of carcinoma of the esophagus is high in this series (16 of 47 patients). The literature is reviewed in relation to the present findings. Follow-up care is described at the Henry Ford Hospital.