[Pathophysiology of injuries and regeneration of peripheral nerves].
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Biomedical subjects
Publications and source records attributed to R Tadić.
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In the period 1991 - 1993, 931 casualties with 1435 injured peripheral nerves were surgically treated at the Clinic for Neurosurgery of the Military Medical Academy. The statistical analyses of these series was done according to the type of the injured nerves, the age and sex of the wounded. The cause of injuries, associated and combined injuries, distribution of single and multiple lesions of certain nerves, as well as employed surgical procedures were analyzed.
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Anatomical characteristics and clinical importance of congenital anomalies of cerebral arteries were examined based on the results obtained by dissection of the circle of Willis blood vessels of 70 native cadaveric brains. Anomalies were most frequently found in posterior communicant artery and their most frequent type was hypoplasia of the blood vessel. Multiple anomalies of the circle of Willis were found in 3 cadavers. Premortal neurological symptomatology (PNS) existed in 5 cadavers. There was no significant difference in PNS occurrence at autopsy in cases with or without anomalies. Association of aneurisms with anomalies of the circle of Willis was found in two cases, but it was not significant in comparison to the control group with no anomalies.
Vascularization, drainage and clinical presentation were analyzed on the series of 25 patients with cerebral arteriovenous malformations (AVM), diagnosed by pancephalic angiography. Monoarterial vascularization was most frequently seen in frontally localized anomalies, and drainage was always done by the nearest major venous vessel (dural sinus of Galen's vein). Initial symptom was intracranial bleeding in 60%, and epilepsy in 40%. Intraventricular bleeding occurred initially in all paraventricular AVMs. All focal attacks occurred in parietal AVMs, all psychomotor in temporal AVMs and 80% of generalized attacks occurred in cases of frontal anomalies. The most frequent symptom was headache (44%).
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The retrospective study includes 24 wounded persons with iatrogenic peripheral nerve lesion and 94 wounded whose neural damage occurred due to peripheral nerve engagement in scar tissue after main artery reconstruction, missile bone fracture or after soft tissues defects covering by Tiersch transplants. The authors analyzed frequency and localization of these lesions, intraoperative findings, applied operative procedures and clinical findings during preoperative follow-up. It is recommended to create the new bad for exposed peripheral nerve from adjacent muscles as part of primary surgical wound treatment. This procedure eliminates the risk of subsequent epineural scar formation in all situations that have been described (soft tissue defects, artery reconstruction and bone fracture) and makes the later operations on peripheral nerves unnecessary.
The results of surgical treatment of 397 wounded with 482 neurotmeses (64 median, 97 ulnar, 100 radial, 7 musculocutaneal, 120 peroneal and 94 tibial nerves) were analyzed. The treatment outcome was determined 12-36 months postoperatively by analyzing the sensorimotor recovery, EMNG status and operated person's attitude to the repair outcome. The change of all the four mentioned parameters was graded from 0 to 5 points, and the outcome was qualified as poor, moderate, good or excellent according to the point sum total. The majority of good and excellent results was obtained after radial (85%) and musculocutaneal (100%) nerve repairs and the less after peroneal nerve repair (13.3%). Based on the obtained results, it was concluded that radial and musculocutaneal neurotmeses should always be repaired, disregarding the height of lesion. Repair of high ulnar and peroneal lesions was unsuccessful. High lesions of tibial and median nerves should be repaired because of the possible recovery of protective sensibility in autonomous nerve zone.
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From September 1991 to December 1992, 41 patients with nonpenetrating and 84 patients with penetrating craniocerebral injuries were neurosurgically treated at the Military Medical Academy. The severity of injuries was estimated according to GCS and the outcome according to GOS. In 17 out of 27 patients with moderate nonpenetrating CCI, the outcome was favorable, and 5 patients out of 7 with severe CCI died (p < 0.01). Out of 33 patients with moderate penetrating CCI, favorable outcome or moderate disability were observed in 21 patients, and out of 26 patients with severe CCI, 19 died (p < 0.01). The majority of unilobar CCI resulted in favorable outcome or moderate disability, while 10 out of 26 patients with multilobar CCI, as well as 9 out of 16 patients with bichemispheric CCI died (p < 0.01). Mortality rate in patients with penetrating CCI was 25%. No significant differences were observed in the outcome of penetrating CCI in relation to the missile type (p > 0.05). Nonpenetrating CCI had a better outcome than the penetrating ones (p < 0.05). The outcome of war nonpenetrating CCI depended on the severity of injury and of penetrating CCI on the severity injury, of the extent of cerebral lesion and the form of penetration, respectively.
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