Biomedical subjects

R Takushi

Publications and source records attributed to R Takushi.

2 recordsLinked to original sources

PubMed1991

Cognitive function, mood and P3 latency: effects of the amelioration of anemia in dialysis patients.

Attention difficulties and psychomotor slowing associated with depressed mood affect the ability of individuals to perform on most neuropsychological tests. It has been suggested that latency of the P3 (P300) component of the event-related EEG potential is an index of neurocognitive status which is not affected by mood. Dialysis patients, who experience diminished dysphoric mood with the reversal of anemia when treated with recombinant human erythropoietin (rHuEPO), were tested for neurocognitive performance, mood and latency of P3. Prior to rHuEPO treatment mood was dysphoric, and neurocognitive testing showed mild deficits, but P3 latency was normal. After treatment, mood improved and neurocognitive test performance was normal. P3 amplitude increased over frontal areas, while P3 latency remained unchanged. Thus, in the case of dysphoric mood, P3 latency may provide a more accurate index of cognitive capacity (as opposed to level of functioning) than neurocognitive test measures.

Affect↗

PubMed1985

Fluprazine hydrochloride does not decrease defensive behaviors of wild and septal syndrome rats.

Recent studies indicate that fluprazine hydrochloride reduces offensive attack in laboratory rats and mice without decreasing defensive behavior during conspecific encounters. Since wild rats and rats displaying the "septal lesion syndrome" show much more pronounced defensive reactions than do normal laboratory rats, these animals were used to provide a more critical test of fluprazine's effectiveness on defense. When a dose of fluprazine hydrochloride (8 mg/kg), previously shown to be highly effective in reducing or eliminating offense, was given to wild and septal syndrome rats these animals showed no reliable decrement in a wide range of defensive reactions including biting attack (defensive attack) to human handling and other stimulation. These findings support the view that fluprazine does not appreciably affect defensive attack or other defensive behaviors even though it strongly inhibits offensive attack.

Aggression↗