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Biomedical subjects

R Tatarelli

Publications and source records attributed to R Tatarelli.

At least 19 recordsLinked to original sources
PubMed2005

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.

Antidepressant drugs have a clinical latency that correlates with the development of neuroadaptive changes, including down-regulation of beta-adrenergic receptors in different brain regions. The identification of drugs that shorten this latency will have a great impact on the treatment of major depressive disorders. We report that the time required for the antidepressant imipramine to reduce the expression of beta-adrenergic receptors in the hippocampus is reduced by a co-administration with centrally active ligands of type 2/3 metabotropic glutamate (mGlu2/3) receptors. Daily treatment of mice with imipramine alone (10 mg/kg, i.p.) reduced the expression of beta-adrenergic receptors in the hippocampus after 21 days, but not at shorter times, as assessed by western blot analysis of beta1-adrenergic receptors and by the amount of specifically bound [3H]CGP-12177, a selective beta-adrenergic receptor ligand. Down-regulation of beta-adrenergic receptors occurred at shorter times (i.e. after 14 days) when imipramine was combined with low doses (0.5 mg/kg, i.p.) of the selective mGlu2/3 receptor agonist LY379268, or with the preferential mGlu2/3 receptor antagonist LY341495 (1 mg/kg, i.p.). Higher doses of LY379268 (2 mg/kg, i.p.) were inactive. This intriguing finding suggests that neuroadaptation to imipramine--at least as assessed by changes in the expression of beta1-adrenergic receptors--is influenced by drugs that interact with mGlu2/3 receptors and stimulates further research aimed at establishing whether any of these drugs can shorten the clinical latency of classical antidepressants.

Adaptation, Physiological↗
PubMed2005

Postpartum depression without delivering a child?

OBJECTIVE: Depression in people related to delivering women is documented in their mates, but only anecdotal in other family members. We describe a case of depression in a woman who had previously experienced postpartum depression after the birth of her nephew. METHOD: A clinical description of the case. RESULTS: A 53-year-old woman, hysterectomized at age 47 years, was admitted for attempted suicide. She developed major depressive episode 1 month after her daughter had delivered a son. She had a past history of two postpartum depressive episodes clinically identical to the current episode. The episode resolved after 5 weeks. At 1-year follow-up, the patient is still asymptomatic. CONCLUSION: Psychological and cultural factors were at play in this case more than hormonal and biopsychosocial ones.

Alprazolam↗
PubMed2000

[Psychiatric approach to the clinical aspects of drug dependence: psychiatric comorbidity in drug addicts].

The authors analyze the most important theoretical models in the field of drug addiction: the moral, the medical, the psychodynamic and the psychiatric model, with particular reference to the concepts of comorbidity and dual diagnosis. It is pointed out as these approaches invariably lead to a dichotomy between the "defect/process" model and the "conflict/development" model. The proposed hypothesis is an attempt to reconcile the opposite points of view in an unitary vision: on the basis of the fundamental psychopathological elements (drive dyscontrol and dependence), the addicts are so distributed into three areas, different for nosography and treatment.

Comorbidity↗
PubMed1998

Peduncular hallucinosis following a transoral odontoidectomy for cranio-vertebral junction malformation. A case report.

This is a case report of a sixty-two years old man suffering from a cranio-vertebral malformation whose dens epistrophei was removed through a transoral approach. During the postoperative course, he experienced a transient peduncular hallucinosis probably caused by surgical trauma on his brainstem. The possible physiopathological, etiopathological, clinical, and therapeutic aspects of this rare phenomenon are discussed.

Hallucinations↗
PubMed1995

Intracranial meningiomas in the 9th decade of life: a retrospective study of 17 surgical cases.

The general availability of cerebral computed tomographic and magnetic resonance imaging scans makes the observation of symptomatic intracranial meningiomas in very elderly patients (aged 80 yr or more) relatively frequent. A few authors have reported on patients who have undergone surgery for intracranial meningiomas in their 9th decade of life, without providing indications regarding the surgical criteria and the prognostic factors. We report on a series of 17 patients who have received surgery for intracranial meningiomas in their 9th decade of life, with the goal of determining some surgical criteria for general physicians and neurosurgeons. Patients with severe systemic disease and definite functional limitations (American Society of Anesthesiology Class III) had a major postoperative morbidity (P = 0.020) and mortality (P = 0.005), especially if they scored low (< 70) on the preoperative Karnofsky Rating Scale (P = 0.010). The risk of postoperative morbidity was higher when the maximum diameter of the tumor was > 5 cm (P = 0.031).

Aged↗
PubMed1994

[Temporary aspects of aging: a new approach to the problem].

Medical, psychologic and social problems are typical of the old age. Usually growing old means organic impair, loneliness and a lower social role; moreover, spatial behavior is completely reduced. The period could be lived and be considered in a different way, although aging is unavoidable. This work suggests that we should consider the passing of time a most comprehensive way. The cyclic, biological time can be replaced by a time which considers and gives expression to everybody's needs and activities. The first aim is to give the elderly a new social role, necessary to avoid a "ecosystemic destabilization". Therefore social workers should supply the aged with a new education at "lived time", as a new therapy form.

Aged↗
PubMed1993

[Considerations on the concept of suggestion in relation to pharmacology].

After some brief considerations on the history of the concept of suggestion, the authors evaluate the importance of this concept in the doctor-patient relationship in which the pharmacological variable is present. They report their personal experience through a case report and hope for an integrated approach in which the drug could be seen as a biological and relational agent.

Adult↗