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Biomedical subjects

R Tello de Meneses

Publications and source records attributed to R Tello de Meneses.

4 recordsLinked to original sources
PubMed1996

[Cardiomyopathies (VII). Natural history of hypertrophic cardiomyopathy].

After a short historic review of conceptual developments in hypertrophic cardiomyopathy, the natural history of the disease is analyzed according to each of its morphologic and functional abnormalities. The lack of association between hypertrophic morphology and sudden death is considered. Diastolic dysfunction and LV obstruction, although a frequent cause of dyspnea and heart failure, is not a risk factor for sudden death. Something similar occurs with the infrequent appearance in this disease of contractile failure. Myocardial ischemia is frequent in hypertrophic cardiomyopathy and general prognostic information about it is still lacking. Nevertheless, in young patients with family history of sudden death, a positive Thallium effort test may be a marker of sudden death (without an arrhythmogenic substrate), and may respond to verapamil. Finally, the new knowledge about genetic mutations in hypertrophic cardiomyopathy are analized. We conclude with some futuristic comments about hypertrophic cardiomyopathy.

Adolescent↗
PubMed1996

[Pulmonary hypertension: current aspects].

Primary pulmonary hypertension, although less frequent than secondary forms, represents the true paradigm of this disease. The recent investigations on pulmonary vascular response mechanisms to different stimuli has increased our knowledge about the mechanism of high pulmonary pressure. Molecular biology of the endothelial cell has provided evidence that endothelial injury plus a genetic individual predisposition may be the pathogenic mainstream of this disease. The histologic findings of pulmonary hypertension are still a matter of controversy, although the clinical, epidemiological and prognostic features are better defined. Therapeutically, there has been important advances, specially with various vasodilators, like calciumantagonists, prostacyclin, adenosine and nitric oxide, as well as new routes of administration. In more advance stages of the disease, atrial septostomy (only paliative) and pulmonary or cardio-pulmonary transplantation, are other therapeutic options to consider, after an adequate selection of patients.

Algorithms↗
PubMed1989

Echocardiographic assessment of cardiac function in the rabbit: a preliminary study.

A technique for obtaining M-mode echocardiograms in sedated adult rabbits of both sexes, New Zealand and California breeds, is described. Despite the fact that with rabbits there are certain technical difficulties in obtaining the M-mode echocardiograms, our preliminary results indicate that the following measurements could be the most useful and accurate: 1) left ventricular systolic time intervals; 2) right ventricular systolic time intervals; 3) right ventricular end-diastolic dimension; 4) left atrial internal dimension; 5) left ventricular end-diastolic and end-systolic dimensions; 6) systolic slope of the interventricular septum; 7) mid-diastolic partial closure of the mitral valve (EF slope); and 8) systolic slope of the posterior aortic wall.

Animals↗