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Biomedical subjects

R Terry

Publications and source records attributed to R Terry.

35 records · Page 2Linked to original sources
PubMed1985

Arteriography of the carotid bifurcation: oblique projections.

Atherosclerotic plaques may not be demonstrated adequately by standard anteroposterior (AP)-lateral projections of carotid arteriography. We evaluated selective carotid arteriography in oblique projections for 60 individual carotid arteries. Two neuroradiologists evaluated arteriograms in four separate sessions devoted to AP-lateral views alone and in combination with oblique projections. The lumen surface was characterized as "smooth," "irregular," or "ulcerated." When oblique projections were added to AP-lateral views, there was a significant shift of radiologic diagnosis from smooth to irregular or ulcerated. Addition of oblique projections to standard AP-lateral views increases the radiographic diagnosis of carotid artery lesions that may be the source of emboli.

Angiography↗
PubMed1979

Cell differentiation rates of Friend murine erythroleukemia variants isolated by sib selection.

Variants of Friend erythroleukemia cells were isolated which produced a high frequency (98%) or low frequency (2%) of hemoglobinized cells after induction with dimethylsulfoxide. Repeated subcloning and sib selection allowed enrichment of different cell lines without the use of mutagens or drug selection. The cell lines do not differ in growth rates, plating efficiencies, or chromosome numbers. The differences in inducibility phenotype were stable for more than 260 cell generations. In addition to differences in induction by dimethylsulfoxide and butyric acid, the cell lines also differ in spontaneous rates of cell differentiation. These results suggest that differences in differentiation rates are an inherited property of cells which is amplified in the presence of nonphysiological inducing agents.

Animals↗
PubMed1979

Propranolol in serum by high pressure liquid chromatography using nitrile (CN) bonded columns in reverse phase.

A method for monitoring therapeutic levels of the beta-blocking and antiarrhythmic drug propranolol in serum has been developed as a high performance liquid chromatography technique using bonded nitrile columns in a reverse phase mode with an aqueous methanol mobile phase containing acetate as a counterion. The performance characteristics of eight different types of reverse phase columns are discussed with evaluation for use in the method. The present method combines basic organic (cyclohexane) extraction with fluorescence detection of the chromatographic effluent to provide a specific, rapid, precise, and reliable technique that has been successfully used to monitor propranolol metabolites or other drugs. The method is shown to compare well with other methods and is suitable for therapeutic drug monitoring by routine clinical laboratories.

Chromatography, High Pressure Liquid↗
PubMed1979

A comparison between a new serological method, thin layer immunoassay (TIA), and the enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies in schistosomiasis.

A comparison has been made of a new serological method, thin layer immunoassay (TIA), and an established method, enzyme-linked immunosorbent assay (ELISA), in the detection and quantification of antibodies in schistosomiasis. Using sera from known S. haematobium and S. mansoni cases, the performance of the two tests was almost identical; 95.6% positive for TIA and 96.4% by ELISA. TIA however produced a small number of false positives with sera from other helminth infections whereas ELISA gave none. There was excellent correlation between the tests in the quantification of anti-S. haematobium antibodies, both in human cases and in infected baboons. TIA has the advantage of being extremely simple to perform, but has the disadvantage of requiring a higher concentration of antigens.

Animals↗
PubMed1979

Closed biopsy of musculoskeletal lesions.

Five hundred and thirty-one closed biopsies have been done in our general hospital since 1967. Four hundred and eighty-four were for lesions of bone and forty-seven were for soft-tissue lesions. More than half of the lesions were infections or nonspecifically reactive. The procedure was done under local anesthesia in 73 per cent and roentgenographic or image-intensifier control was generally required. The Craig needle was used for cancellous bone near vital structures; the Michele trephine, for cortical or sclerotic bone at a distance from vital structures; and a special needle was used for soft tissue. Closed biopsy provided an adequate specimen that was accurately diagnosed in 66 per cent of bone lesions and in 76 per cent of soft-tissue lesions. This compared favorably with both aspiration and open-biopsy success rates reported by others, and was accompanied by a 1 per cent complication rate, mostly neural and mostly in association with vertebral lesions.

Biopsy↗
PubMed1977

Plant thorn synovitis.

Five children with an inflammatory monarthritis due to penetration of the joint by plant thorns are presented. The clinical presentation was that of a transient acute synovitis followed by a relatively asymptomatic period, and later by chronic arthritis often after the thorn injury was forgotten. Histopathology demonstrated a granulomatous synovitis. Polarized light microscopy facilitated identification of the plant tissue within the synovium. Conservative medical therapy was ineffective, but surgical excision of the affected synovium resulted in normal joint function. The differential diagnosis of monarthritis in children in extensive, and awareness of this condition is necessary to elicit a comprehensive history and to avoid delay in treatment.

Arthritis↗
PubMed1977

Diagnostic problems of epithelial tumors of penis.

Malignant epithelial tumors of the penis often present aspects which make difficult an accurate clinical and pathologic diagnosis. Frequently, repeated biopsies yield a benign diagnosis while the tumor continues to progress and sections through it indicate malignant components. It is suggested that epithelial tumors of the penis may consist, in many instances from their start, of a mixture of benign and malignant elements in ratios varying from one extreme to the other. This may explain why biopsies are frequently misleading, yielding a benign result while, in fact, the tumor is malignant.

Aged↗
PubMed1975

Letter: Sinutab.

Explore the source record for details and available documents.

Acetaminophen↗
PubMed1975

Consumption of classical complement components by heart subcellular membranes in vitro and in patients after acute myocardial infarction.

Experiments were conducted to characterize the antibody-independent activation of complement in human serum by isolated human heart mitochondrial membranes in vitro and to determine whether similar patterns of complement consumption occurred in patients after acute myocardial infarction. Direct evidence for the interaction of C1 and heart mitochondrial membranes was obtained by mitochondria-C1 binding and elution experiments. Exposure of normal human sera to isolated human heart mitochondria at 37 degrees C resulted in the consumption of C1, C4, C2, and C3 without significant consumption of the terminal components of the complement system (C6 through C9). The consumption occurred in the absence of detectable anti-heart mitochondria autoantibody, was demonstrated to be calcium dependent, and was inhibited by either 0.01 M EDTA or ethylene glycol bis(bets-aminoethyl ether) N,N,N',N',-tetraacetic acid (EDTA). Although specific absorption of C1q from human sera inhibited the mitochondria-dependent activation of C4, C3 donsumption was not affected. These data indicate that the consumption of C4 and C2 likely occurred due to the mitochondrial membrane-mediated activation of C1, but that the consumption of the C3 did not necessarily involve either the classical or alternative complement pathways. After the in vitro characterization of the mitochondria-dependent activation of the complement system, additional studies were performed to determine whether similar consumption occurred in patients after acute myocaridal infarction. During a 72-h period after hospital admission significant decreases in C1, C4, and C3 occurred in six patients with recent chest pain but no evidence of acute myocardial infarction. These studies suggest that myocardial cell necrosis results in the release of subcellular membrane constituents capable of activating the complement system in the absence of detectable anti-heart autoantibodies; such activation may be responsible in part for the development of acute inflammation and evolution of the infarct size following coronary artery occulusion.

Autoantibodies↗
PubMedDate not supplied

Rigid gas permeable lenses and patient management.

The introduction of new rigid gas permeable (RGP) contact lens materials provides the practitioner with a number of alternatives for patient management. But whatever the lens materials used, problems related to the lenses, care and maintenance solutions, and patients may arise. This paper examines concerns such as parameter instability, durability of lenses, compatibility of materials and solutions, patient education and compliance, 3 and 9 o'clock staining, corneal distortion, and lid changes. Suggestions are made on ways to avoid or minimize problems related to RGP lens wear.

Contact Lenses↗
PubMedDate not supplied

A systemic lupus erythematosus-like syndrome induced by procainamide.

A syndrome that resembles Systemic Lupus Erythematosus both clinically and on laboratory studies may be induced by procainamide. It is associated with multisystemic involvement, positive Antinuclear Antibody titers (ANA), and positive LE cell preparations. In patients on procainamide therapy the syndrome must be differentiated from osteoarthritis, myocardial infarction, and pulmonary embolism. When procainamide is discontinued, this Lupus-like syndrome is usually reversible. Other drugs, including hydralazine and isoniazid have also been implicated in provoking this Lupus-like syndrome.

Aged↗