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Biomedical subjects

R Tessler

Publications and source records attributed to R Tessler.

16 recordsLinked to original sources
PubMed2006

Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire, arousal and sexual function.

Although there is some evidence from twin studies that individual differences in sexual behavior are heritable, little is known about the specific molecular genetic design of human sexuality. Recently, a specific dopamine D4 receptor (DRD4) agonist was shown in rats to induce penile erection through a central mechanism. These findings prompted us to examine possible association between the well-characterized DRD4 gene and core phenotypes of human sexual behavior that included desire, arousal and function in a group of 148 nonclinical university students. We observed association between the exon 3 repeat region, and the C-521T and C-616G promoter region SNPs, with scores on scales that measure human sexual behavior. The single most common DRD4 5-locus haplotype (19%) was significantly associated with Desire, Function and Arousal scores. The current results are consistent with animal studies that show a role for dopamine and specifically the DRD4 receptor in sexual behavior and suggest that one pathway by which individual variation in human desire, arousal and function are mediated is based on allelic variants coding for differences in DRD4 receptor gene expression and protein concentrations in key brain areas.

Family Health↗
PubMed2001

The proportion of veterans among homeless men: a decade later.

BACKGROUND: The purpose of this report is to evaluate the risk of homelessness among veterans as compared to non-veterans, and to ascertain whether the exceptionally high risk of homelessness among post-Vietnam era veterans first observed in 1987 was still evident one decade later. METHOD: Data from the 1996 National Survey of Homeless Assistance Providers and Clients and the 1996 Current Population Survey were used to examine the risks of homelessness among veteran men as compared to non-veteran men, stratified by age and race. RESULTS: The present results show that the cohort of veterans aged 20-34 that was most at risk in the 1980s, although no longer the youngest, still has the highest risk for homelessness. In 1996, the youngest cohort of veterans is also over-represented, but not to the extent found among young men 10 years before. Veterans over the age of 55 showed no increased risk of homelessness as compared to non-veterans. CONCLUSIONS: The observed cohort effect, which demonstrates an especially high risk of homelessness among veterans of the immediate post-Vietnam era, even as they age, may reflect the continuing influence of the early problems in recruiting for the All Volunteer Force (AVF). In contrast to the national draft, which promised a fair representation of the entire population of draft-eligible young men, the AVF also had the potential to attract young men with fewer alternative opportunities.

Adult↗
PubMed2000

Factors predicting choice of provider among homeless veterans with mental illness.

OBJECTIVE: Homeless persons with serious mental illness are especially likely to lack access to comprehensive medical and psychiatric care. This study examined the relative importance of predisposing factors, illness factors, and enabling factors as determinants of the use of Veterans Affairs (VA) health care services by mentally ill homeless veterans seeking services from a non-VA program. Predisposing factors included demographic characteristics and wartime service; illness factors were related to the type of medical problem and the need to seek medical care; and enabling factors included entitlement to VA medical services and location of VA facilities. METHODS: Logistic regression analysis was used to analyze data for 698 homeless veterans with mental illness who were enrolled in the Access to Community Care and Effective Services and Supports (ACCESS) program. RESULTS: About 56 percent of the mentally ill homeless veterans had used VA services at some time in their lives. Homeless veterans were almost twice as likely as other poor veterans to use VA services; those with a dual diagnosis were also more likely to use VA services. Enabling factors were more important than either predisposing or illness factors in predicting VA service use. Veterans most likely to use VA services were those who received VA benefits that gave them priority access to VA services and those who lived near a VA medical center. CONCLUSIONS: Specific characteristics of the service system and of veterans' entitlement were more important than clinical needs or predisposing factors in predicting service use.

Adult↗
PubMed2000

Military discharge status of homeless veterans with mental illness.

The high proportion of veterans among homeless men is perplexing given the opportunities associated with military service and the benefits long available to veterans. One little-examined risk factor for homelessness is that many homeless men may have received punitive discharges that result in ineligibility for Department of Veterans Affairs benefits. Data from a sample of homeless male veterans with mental illness enrolled in the Access to Community Care and Effective Services and Supports Program are used to examine punitive discharges as a risk factor for homelessness and to compare veterans with punitive and non-punitive discharges on premilitary, military, and postmilitary experiences. Only 7% of homeless veterans received punitive discharges. Pre-military experiences are associated with such discharges, but military experiences are not. Although a punitive discharge is a strong risk factor for subsequent homelessness, such discharges primarily reflect premilitary vulnerabilities and are a relatively minor reason for homelessness because they affect a small proportion of the general veteran population.

Adult↗
PubMed1994

Continuity of care, residence, and family burden in Ohio.

Family and client data from the RWJF initiative in three Ohio cities are linked. The distribution of burden for a sample of 305 family members is reported. Burden is measured by assistance with the activities of daily living, attempts to prevent or stop troublesome behaviors, and worries about the client. The impact of continuity of care is evaluated for the total sample and in interaction with shared residence. Although continuity has no direct effect on any measure of burden, it can offset the objective burdens associated with shared residence. Without continuity of care, coresidence tends to increase the burden of caregiving and supervision. Client involvement in the professional system of care has less impact on family members when the client lives apart. The objective burden falls most heavily on spouses and parents; adult children and secondary kin are less affected.

Adult↗
PubMed1989

Role incongruence and gender variation in the provision of prison mental health services.

Correctional administrators are equipped with a variety of responses to manage problematic inmate behavior. The forms of these responses range from subtle coercion in the context of everyday prison life to segregative placements that include protective custody, disciplinary confinement, and mental health residential services. Using logistic regression, the present study examines the disproportionate placement of female inmates in mental health facilities. The results suggest that placement differences for male and for female inmates reflect both psychiatric need and differential responses to role-incongruent behavior.

Adult↗
PubMed1980

Birth order, family size, and children's use of physician services.

The purpose of this study is to separate out the effects of number of siblings and birth order on children's use of physician services. Prior research has consistently revealed an inverse relationship between family size and physician visits, but the possible confounding influence of the child's ordinal position in the family has been ignored. Later born children may be taken to the doctor less often than first and other early borns because of their parents' increasing knowledgeability in regard to child care as well as their growing understanding of the uses and limitations of physician visits. On the assumption that part of the family size effect observed in prior research may have been due to the clustering of first and early borns in small families, an inverse relationship between birth order and physician utilization is hypothesized. Support for this hypothesis comes from an empirical study of 1,665 children from 587 families in which variation in family size is statistically controlled.

Adult↗
PubMed1979

Continuity of care in the delivery of mental health services.

The authors report on the help-seeking experiences of people referred to community settings for aftercare on discharge from a state mental hospital in western Massachusetts. They present results that bear on three questions relevant to public policy issues in the mental health field: 1) the proportion of patients who comply with referrals to aftercare agencies, 2) the social and psychological characteristics of patients who comply with these referrals, and 3) the impact of receiving aftercare on the probability of rehospitalization.

Adult↗
PubMed1978

Factors affecting children's use of physician services in a prepaid group practice.

This paper examines factors affecting children's use of physician services in a prepaid group practice. The independent measures come from questions asked of mothers in a survey interview, while the utilization data come from their children's medical records. All independent variables were measured prior to the period of utilization studied. The results provide some evidence in support of the view that physician utilization for children is affected by characteristics of the mother, as well as the child's age and health status. Somewhat different variables were related to whether health services were used at all as compared with magnitude of use. Special consideration is given to the effect of the mother's level of psychological distress on her propensity to use medical services for children. The results suggest that distress was relevant, but only for the white families included in the sample. Also, distress was more important in explaining extent of use than accounting for whether utilization occurred at all. Various hypotheses are examined to explore white-nonwhite differences.

Adult↗
PubMed1976

The effect of psychological distress on physician utilization: a prospective study.

This paper examines the hypothesis that psychological distress is causally related to physician utilization among enrollees in a prepaid group practice. Measures of distress are constructed from questions included in a servey interview, while the utilization data come from medical records. Distress levels were measured prior to the period of utilization studied. The results show a positive relationship between distress and physician utilization, which persists even when a variety of sociodemographic, attitudinal, and health status variables have been controlled. The results are discussed in terms of a perspective that emphasizes social-psychological needs as triggers for physician utilization

Adult↗
PubMed1975

The proteins of the content of the secretory granules of the rat parotid gland.

The proteins of the secretory granules of the rat parotid gland were characterized by sodium dodecylsulfate gel electrophoresis, by chromatography of [3-H]proline-labeled proteins on DEAE-cellulose and by amino acid analysis. Sodium dodecylsulfate gel electrophoresis of the secretory granule content showed five principal proteins and a limited number of minor components. Only two of the principal bands could be identified as known secretory enzymes of the parotid gland. One was identified as the alpha-amylase and one as deoxyribonuclease. Peroxidase and ribonuclease form minor portions of the secretory proteins. The other three major proteins constitute, together, about 60% by weight, of the secretory granule content proteins. Of these, one which represents more than 30% of the total granule protein was found to contain uniquely high amounts of leucine residues (21 mole%). Another one of these principal proteins was relatively rich in cysteine residues (7 mole%). The fifth principal protein was found to contain high amounts of proline (28 mole%) glutamic acid (17 mole%) and glycine (18 mole%) residues. Its amino acid composition was very similar to that of the proline-se granules. This protein, however, differed from the "membranous" proline-rich proteins by several criteria. Two minor glycoproteins of the secretory granule content were also found to be rich in proline residues (37 mole%). As with the other proline-rich proteins of the granule, they contained no sulphur-containing amino acids, stained faintly pink with Coomassie Blue and were underestimated by the Lowry method. They differ however, from all the other proline-rich proteins of the granule by having a significantly higher content of threonine, less glycine (9 mole%) and much less glutamic acid (3 mole%). Of the principal proteins, only the deoxyribonuclease and the half-cystine-rich proteins were positively stained by periodic acid Schiff staining. The possible functions of the leucine-rich, the half cystine-rich and the various proline-rich proteins are discussed.

Amino Acids↗
PubMed1975

Factors affecting the choice between prepaid group practice and alternative insurance programs.

This paper examines the basis for the selection of prepaid group practice in a dual-choice situation, and the social, attitudinal, and health characteristics of populations choosing prepaid programs in contrast to other plans. When asked in an open-ended way why they made the decisions they did, those selecting prepaid group practice most frequently referred to the more comprehensive coverage provided and to the fact that at the time of choice they lacked a continuing or adequate relationship with a physician. Enrollees in the prepaid program were better educated and, contrary to previous research, more likely to be unmarried. There was little evidence that enrollees in the prepaid plan brought with them distinctive kinds of attitudes and orientations toward illness and medical care. Enrollees in the prepaid program were also comparable to those retaining an alternative health insurance option on a number of indicators of health status. However, prepaid practice enrollees tended to report more chronic conditions than persons who declined to enroll in the prepaid program. Although the overrepresentation of persons with chronic illnesses is not large, data drawn from a related study suggests that persons with several chronic conditions tend to be heavy users of medical services.

Adult↗