Biomedical subjects

R Tomásek

Publications and source records attributed to R Tomásek.

At least 19 recordsLinked to original sources

PubMed1989

[Ocular complications in treatment with antitubercular agents in patients with chronic kidney failure on regular dialysis therapy].

A 22 years old woman suffering from renal insufficiency has been treated for 4 years by means of regular dialysis. Two years after the beginning of this therapy the renal transplantation was performed, but the graft was removed after 3 weeks. The hypertonic neuropathy was diagnosed. Patient was treated with antituberculotics, Imuran and Prednisone. After Ethambutol treatment indicated for pulmonar tbc (daily dose 11 mg per kg, the total dose of 33,6 g) the ocular side effects were pronounced: the toxical damage of both optical nerves, bilateral decrease of vision for distance and near, minute scotoma in the retinal centre of the left eye, deterioration of the vision of colours in the sense of deuteranopia. Complications were reversible, when the therapy with Ethambutol was discontinued and patient was treated with vitamins and Prednison in the total dose of 1,420 g. Authors mention also some other signs of ocular toxicity of antituberculotics.

Adult↗

PubMed1989

[Changes in the ocular fundus in patients with chronic kidney failure on regular dialysis therapy].

Investigation of changes of the ocular fundus by ophthalmoscopy, coloured photography and fluoroangiography confirmed assumptions that the most frequent finding is hypertonic angiopathy and angiosclerosis. Hypertonic retinopathy and neuroretinopathy were recorded only in one quarter of the cases, most frequently during the initial years of dialysation treatment. The part played by a high blood pressure in chronic renal failure before and during dialyzation treatment is important. Under the influence of many metabolic changes in dialysed patients a general affection of the blood vessels and tissues of the retina, choroid and optic nerve develops. The appearance of the ocular fundus in the patient reminded of findings in subjects by two or more decades older and supported thus the theory of hastened ageing in chronic renal failure with regular dialysation treatment.

Adult↗

PubMed1989

[Changes in the lens and cataract surgery in dialyzed patients].

In the course of a 15-year investigation period we recorded among 119 patients with chronic renal failure who had regular dialysation treatment cataract in 17 subjects, i.e. in 14.3%. The authors did not observe during the investigation period changes of refraction nor reversibility of the cataract. Seven patients were operated on one or both eyes, i.e. 5.8%. The paper contains a detailed analysis of surgical complications and aetiopathogenetic reflections on possible causes of dialysation cataracts. In 10 operated eyes the authors achieved very good functional results, the patients survived with good vision on average for 2.25 years. One failure was due to atrophy of the disc of the optic nerve after hypertonic neuroretinopathy. Because of frequent complications during and after operation the authors recommend to perform cataract operations in dialysed patients in selected departments with the possibility of constant nephrological consultant services.

Adult↗

PubMed1988