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Biomedical subjects

R Tompsett

Publications and source records attributed to R Tompsett.

14 recordsLinked to original sources
PubMed1980

Infections of hairy cell leukemia. Clinical evidence of a pronounced defect in cell-mediated immunity.

We compared infection rates in 12 patients with hairy cell leukemia (a malignant neoplasm for which the cell of origin remains controversial) with rates in 15 patients with chronic lymphocytic leukemia (a known B-lymphocyte neoplasm) recently treated at four Dallas hospitals. We found a significantly higher over-all rate of infections in the patients with hairy cell leukemia (P = 0.004 BY Gehan's variation on the generalized Wilcoxon test). This increased rate was primarily due to a significantly higher rate of infections normally controlled by the cell-mediated immune system (P = 0.005). Despite these findings, five of six patients with hairy cell leukemia who were skin-tested exhibited intact delayed type hypersensitivity, and each of the three patients examined serologically produced antibodies normally in response to recent infections. A review of the case records of 173 previously described patients with hairy cell leukemia, demonstrated a similar predilection of patients with this disease for infections normally controlled by cell-mediated immunity. In this regard, they were similar to previously described patients with Hodgkin's disease. Both over-all infection rates and rates of fatal infection were highest in patients with hairy cell leukemia who received chemotherapy as their sole form of treatment and lowest in those who underwent splenectomy as their only form of antitumor therapy.

Adult↗
PubMed1978

Enterococcal endocarditis: duration and mode of treatment.

This report summarizes data on sixteen patients with enterococcal endocarditis treated with penicillin and streptomycin. The experience reported suggests that a four week period is adequate for routine therapy in these patients, as in other forms of streptococcal endocarditis. It provides an additional group of patients successfully treated with penicillin and streptomycin. Two relapses were encountered. One of these received inadequate daily doses of penicillin. The other patient was clearly a failure of penicillin and streptomycin, but the failure in this instance could not be attributed to foreshortened treatment (6 weeks) or to high level streptomycin resistance of the infecting strain of Enterococcus.

Adult↗
PubMed1976

Histoplasmosis: twenty years experience in a general hospital.

This report summarizes the clinical and laboratory data on 57 patients with histoplasmosis, including 13 with progressive disseminated disease. The experience in general is supportive of that of others in that although infection with Histoplasma capsulatum is prevalent, clinical disease is uncommon and disseminated disease actually rare. The data again emphasize the limitations of diagnostic methods, and in particular point up the need to obtain cultures of biopsy material from mucocutaneous lesions.

Histoplasmosis↗
PubMed1965

In Vivo Studies on Staphylococcal Penicillinase.

Eyckmans, Luc (Baylor University Medical Center, Dallas, Tex.), and Ralph Tompsett. In vivo studies on staphylococcal penicillinase. J. Bacteriol. 90:589-593. 1965.-The amounts of staphylococcal penicillinase present in tissue of mice with well-established infections due to penicillin-resistant staphylococci were determined. The data indicate that, in the presence of such infection, penicillinase can be found in amounts adequate to destroy large amounts of penicillin. These results are found in the absence of any conditions which are known to induce penicillinase. Although it has been generally assumed that penicillinase does account for the penicillin resistance of certain staphylococci in vivo, the data presented here document the quantitative aspects of this phenomenon, and indicate that the amounts of penicillinase produced are sufficient to account for the high degrees of resistance observed.

Journal Article↗
PubMedDate not supplied

Granulomatous synovitis: the role of atypical mycobacteria.

Clinical data on 25 patients with granulomatous synovitis and bursitis observed from 1970 through 1977 are reviewed. The lesions occurred about the extremities, the wrists and hands being involved most often. With three exceptions, the patients had no significant underlying disease. The lesions were chronic and often followed minor trauma. Many patients had had prior surgery, steriod injections, or both. At the time of surgery for the synovitis, the gross appearance proved to be relatively characteristic, and microscopic examination revealed granulomatous inflammation. Mycobacteria were found in 20 patients. In 15 of these cases, mycobacteria were isolated in cultures; in an additional five cases, acid-fast bacilli were seen in the excised tissue but cultures were negative. The species isolated were Mycobacterium tuberculosis (four cases), Mycobacterium kansaii (six), Mycobacterium marinum (one), Mycobacterium gordonae (one), Mycobacterium avium-intracellulare (two), and Mycobacterium chelonei (one). The clinical results after therapy that combined surgery and antimicrobial agents were generally favorable. It is stressed that surgical specimens should be sent for appropriate cultures as well as for histologic study.

Adolescent↗