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R Toulouse

Publications and source records attributed to R Toulouse.

At least 19 recordsLinked to original sources
PubMed1981

[Application of a rapid serum beta-hCG assay in the early diagnosis of the ectopic pregnancies (author's transl)].

We have assessed the clinical utility of a rapid serum beta chorionic gonadotropin ( beta-hCG) assay. The assay employed a commercial kit that we have modified to assure its validity. We reach a sensitivity of 10 mIU/ml, and inter assay precision of 8,1% and an intra assay precision of 6.4 and 4.7% for concentrations of 7.6 +/- 0.5 mIU/ml and 1 825 +/- 86.3 mIU/ml respectively. This work was carried out on 106 radioimmune determinations of beta-hCG during the first trimester of 56 normal pregnancies and on 168 levels estimed in 116 suspected ectopic pregnancies. In normal pregnancies, a trophoblastic secretion of beta-hCG is detected on the 10th day following the thermal nadir; the levels quickly rise to reach a peak between the 42th and the 52th post-ovulation day, and then gradually decrease. In the 116 suspected pregnancies, 40 of them were surgically proven ectopic gestations: there were no false positive or false negative results. This rapid and accurate assay may contribute to the early diagnosis of an ectopic pregnancy.

Chorionic Gonadotropin↗
PubMed1980

[Hydramnios and fetal malformations. A consecutive series of 50 cases which were under observation in the maternity unit of C.H.U. of Rennes between 1971 and 1978 (author's transl)].

50 cases of hydramnios were found in 17,528 deliveries. This gives a percentage of 0.29. These 50 cases of hydramnios gave birth to 53 fetuses which showed one or more of the following abnormalities. 20 malformations of which 12 were of the central nervous system; 6 twins; 6 cases of Rhesus allo-immunisation; 1 case of chorio angioma; 4 unexplained intra-uterine deaths; and 27 infants that died later. No etiological cause for this hydramnios was found in 20 cases. There was no maternal pathology to be found. Often the obstetrical histories of these women are pathological. In 3 per cent of the cases there was a previous abortion and in 18 per cent it appeared that there was previous hydramnios. We discuss what measures should be taken in cases of hydramnios. In our opinion a woman who has had a pregnancy with hydramnios should have genetic counseilling. The combination of hydramnios with delayed intra-uterine growth suggests that fetal malformation is present.

Female↗
PubMed1980

[Multiple pregnancies. Apropos of 37 cases].

Induction with ovarian stimulators and especially HMG together with HCG are the principal causes of multiple pregnancies as has been revealed by the studies of 37 case histories of multiple pregnancies over and above twin pregnancies. It is important to be very careful and take strict precautions with these patients who often have psychological troubles that have to be treated first. It is useless to carry out cerclage (cervical stitching) after these triplet and quadruplet pregnancies have been diagnosed early by systematic echography, which should be used in every case where ovulation is induced. It is essential to supervise these patients in a special centre. The children tend to be small for datas and it is best to deliver them by cesarean section at 35 weeks onwards. It is important to avoid these very pathological pregnancies as far as possible. Echography of the ovary should be routine before induction of ovulation.

Cesarean Section↗
PubMed1979

[Acute exacerbation of prolactin-secreting adenomas during pregnancy following the treatment of sterility. 2 cases (author's transl)].

These 2 cases were similar in terms of the time of onset of problems at the 8th month, the clinical and radiological signs of the tumour, and the existence of an amenorrhoea-galactorrhoea syndrome with hyperprolactinaemia. They differed with regard to the mode in which the pregnancy was obtained: one was induced by anti-prolactins in the presence of a normal sella turcica whilst the other began during the cycle following the administration of clomiphene with no prior radiological study of the sella turcica. They also differed in terms of the course: intra-tumoural haematoma requiring early surgery in one, hyperplasia and oedema regressing after delivery in the other making it possible to avoid immediate treatment.

Adenoma↗
PubMed1979

[Pregnancy and portal hypertension due to a pre-hepatic block. 3 case histories (author's transl)].

The authors studied the prognosis for the pregnancies in cases of portal hypertension due to pre-hepatic block in 3 patients who between them had 6 pregnancies without having had previous porto-caval anastomoses. In spite of the good results that they had in their cases the literature shows that the condition is a high-risk pregnancy condition: 44 p. 100 of cases have intestinal tract haemorrhages, 19 p. 100 have premature labour and the perinatal mortality is somewhere between 11 and 18 p. 100. The babies are usually delivered vaginally with the aid of an assisted delivery.

Adolescent↗