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Biomedical subjects

R Traub

Publications and source records attributed to R Traub.

At least 37 records · Page 2Linked to original sources
PubMed1983

Rickettsia mooseri infection in the fleas Leptopsylla segnis and Xenopsylla cheopis.

Detailed observations on the acquisition and propagation of experimental Rickettsia mooseri infection in two species of fleas are presented. Rickettsia mooseri infection became detectable by means of the direct fluorescent antibody test about 2 days earlier in Leptopsylla segnis than in the putative vector, Xenopsylla cheopis. By the 6th day after the infective feeding, the entire lining and the lumen of the midgut in L. segnis contained masses of rickettsiae and the agent was being passed in the feces of the flea, whereas in X. cheopis these events did not occur until the 8th day. Basic behavioral differences in the two species of flea may explain these discrepancies and also influence their ability to serve as vectors of murine typhus. As a semisessile flea and sustained feeder, L. segnis only rarely attaches to a second individual and thus has an opportunity to acquire a heavy dose of rickettsiae, if feeding on a rickettsemic host. X. cheopis, in contrast, feeds rapidly and intermittently, even on man, and generally leaves its host soon thereafter, later returning to the same or another host to feed again. While L. segnis may not be as efficient a vector as X. cheopis regarding the intramurine cycle or transmission to man of murine typhus, the dense accumulation of infective feces on certain sites on the fur of the host raises the possibility of air-borne infection to man or rodent. Infection with R. mooseri had no effect on the survival of X. cheopis and L. segnis. Furthermore, no visible cytopathological effect was found in the paraffin-embedded sections of infected fleas.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1977

Immunological response of subacute sclerosing panencephalitis patients to measles virus.

The immunological responses of patients with clinical signs of SSPE were examined by the direct migration inhibition, complement-mediated antibody cytoxicity and the lymphocyte-mediated cytotoxicity assay techniques. Peripheral lymphocytes migrated similarly to controls when exposed to measles antigen. Lymphocytes from SSPE patients responded to a SSPE strain of measles infected cells in a manner similar to lymphocytes from controls. A factor which interfered with the expected activity of sensitized lymphocytes to measles virus was detected in some cerebral spinal fluid obtained from SSPE patients. The blocking activity varied from 100% in 4 of 20 patients with SSPE to no blocking in 2 of the SSPE patients. The occurrence of blocking factor in SSPE patients could not be related to sex or age of the patient, serum of CSF antibody levels, and duration of disease or outcome.

Antibodies, Viral↗
PubMed1976

The susceptibility of the postpartum and postabortal cervix and uterine cavity to infection with attenuated rubella virus.

To determine the susceptibility of the postpartum and postabortal genital tract to infection with attenuated rubella virus, 30 patients with negative hemagglutination inhibition (HI) titers were studied. Following inoculation with Cendehill or RA 27/3 vaccine, viral cultures of the cervix and uterine cavity were obtained with blood specimens to evaluate serologic conversion. Attenuated rubella virus was not isolated in any patient; seropositive conversion was achieved in 24 women. The significance of these findings related to wild rubella virus infection is discussed.

Abortion, Legal↗
PubMed1976

Herpesvirus hominis type II infections in asymptomatic pregnant women.

This study was designed to determine the incidence of previous and current herpesvirus hominis Type II infections in asymptomatic pregnant women. Sera were obtained from 985 patients for detection of Type I and II herpesvirus hominis antibodies. In addition 770 cervical and 211 amniotic fluid cultures for herpesvirus hominis Type II were performed. Identification of previous herpesvirus hominis infection was determined in 352 patients (35.7%) by calculation of a Type II/I antibody index of 85 or greater. Type II herpesvirus hominis was isolated from five cervical cultures for a 0.65% antepartum incidence of infection. None of the amniotic fluid cultures demonstrated virus. The significance of these findings is discussed.

Adolescent↗