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Biomedical subjects

R Tremblay

Publications and source records attributed to R Tremblay.

50 records · Page 3Linked to original sources

Further evidence for the presence of androgen receptors in the lungs and in the head appendages of the cock.

The presence of cytoplasmic dihydrotestosterone receptors in the lungs, the comb, the wattle, and the ear lobes of the cock was demonstrated by sucrose density-gradient centrifugation. All these tissues exhibited saturable 'in vitro' binding of dihydrotestosterone in the 8-11S region of the gradient. When 0.5 M KCl was added to the lung, wattle, and comb cytosol and to the gradients, the radioactive dihydrotestosterone migrated in the 4-5S region. These studies suggest that the mechanism of action of androgens in the head appendages of the cock and in other target tissues is similar.

Animals↗

Path analysis of parents' conservatism toward sex education of their mentally retarded children.

The authors investigated three probable reasons why parents of mentally retarded children would be opposed to sex education being offered as a school subject: general sexual attitudes, specific sexual attitudes, and prejudices against the retarded child's own sexuality. A questionnnaire was given to 60 parents of retarded children and 62 parents of nonretarded children. A correlation analysis revealed evidence of all three kinds of reasons and led to a causal model of conservatism on sex education. A path analysis revealed that (a) sexual prejudices are a major obstacle to sex education, and (b) each group of parents represents a specific dynamic of conservatism on sex education. Means of pedagogical intervention to modify parents' attitudes toward sex education of handicapped children were discussed.

Attitude↗

Development of dental plaque on epoxy resin crowns in man. A light and electron microscopic study.

A method was presented to fabricate epoxy resin crowns to be worn by human subjects requiring full crown restorations. These crowns were utilized in six young adults to study the internal structure of plaque after plaque formation periods of 1 and 3 days, 1 and 3 weeks and 2 months. This study confirmed previous findings that early plaque contains primarily coccal forms, with a shift to predominantly filamentous forms by 3 weeks. Early plaque growth seems to occur by the formation of columnar microcolonies which coalesce and grow by cell division within the colony in a direction perpendicular to the crown surface. Filamentous microorganisms appear in large numbers by 1 week. They appear to colonize the surface of the predominantly coccal plaque, eventually growing into it and replacing the coccal forms. The subgingival, mature plaque contains many motile forms including bacteria with unusual cell wall ultrastructures. Certain bacteria combine into distinctive bacterial aggregations resembling "corn cobs" and "test tube brushes," the latter occurring exclusively in subgingival plaque. Spirochetes appear to grow preferentially on the external surface of subgingival plaque in close contact to the gingival tissue of the deepened sulcus. Their high concentration in the external layer of subgingival plaque suggests that because of their strategic location they may play an important role in the etiology of periodontal disease. Studies of well preserved plaque, possibly combined with the use of serological markers, can serve a useful role in identifying certain microorganisms in dental plaque. Because of their numbers and/or location in relation to periodontal tissues, some of these bacteria may warrant further studies as potential etiologic agents of certain forms of periodontal disease.

Bacteria↗

Selection against blue mussels (Mytilus edulis L.) homozygotes under various stressful conditions.

Three mussel groups differing in mean multilocus heterozygosity (MLH) were used to examine the MLH-fitness relationship. Mussels were submitted to aerobic and anaerobic stressful conditions in the laboratory, and their LT(50) was measured. Mortality was not random in two of the three groups and affected the homozygous individuals more. This selective mortality caused a significant increase in the mean MLH of the survivors, but only for the two groups characterized by the lowest initial MLH and significant deficits in heterozygotes at the onset of the experiments. While these experiments were ongoing, the same two groups also suffered a 40% mortality rate in lantern nets under field conditions. This mortality also increased the mean MLH in survivors. All groups showed strong inverse relationships between MLH and standard metabolism. Our results suggest that the higher resistance of more heterozygous individuals is related to their lower metabolic needs.

Animals↗

Making HIV prevention work in the north.

Meeting the challenges of diverse cultures, numerous languages and great distances, the Northwest Territories discovered innovative ways to promote AIDS prevention. This article discusses obstacles to HIV prevention and techniques used to overcome them commonly found in health services for the NWT. For example, techniques for improved service delivery include reliance on decentralized services provided by regional health boards and Community Health Representatives. Further, the challenges posed by language diversity and cultural taboos against speaking openly about sexual matters have been partially overcome through the conversion of materials and concepts into aboriginal languages which are culturally appropriate. The article specifically discusses two AIDS education campaigns in which these techniques were utilized: namely, Health is a Community Affair Campaign (or the Door-to-Door Project) and local initiatives which hosted presentations by an Aboriginal person living with AIDS.

Adolescent↗