PubMed Health⌕ Search

Biomedical subjects

R Trussell

Publications and source records attributed to R Trussell.

5 recordsLinked to original sources

Partial leptin deficiency and human adiposity.

The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

Adipose Tissue↗

Feasibility of the membrane bioreactor process for water reclamation.

The feasibility of the membrane bioreactor (MBR) process for water reclamation was studied. Process evaluation was based on the following: literature review of MBRs, worldwide survey of MBRs, and preliminary costs estimates. The literature review and the survey have shown that the MBR process offers several benefits over the conventional activated sludge process, including: smaller space and reactor requirements, better effluent water quality, disinfection, increased volumetric loading, and less sludge production. The MBR process can exist in two different configurations, one with the low-pressure membrane modules replacing the clarifier downstream the bioreactor (in series), and the second with the membranes submerged within the bioreactor. Four major companies are currently marketing MBRs while many other companies are also in the process of developing new MBRs. The MBR process operates in a considerably different range of parameters than the conventional activated sludge process. The preliminary cost evaluation has shown that the MBR process is cost competitive with other conventional wastewater treatment processes.

Bioreactors↗

Evaluation of an integrated membrane system for water repurification.

An integrated membrane system was evaluated for water repurification. Performance evaluation of the membrane system was based on three criteria: flux and fouling, disinfection capability, and rejection of pollutants. Minimal membrane fouling was observed for all of the membranes employed in the study. Significant contaminant rejection was also achieved by the membrane system purifying the reclaimed water to meet and exceed drinking water standards. Wide range of virus rejection was observed for the membranes, which was dependent on the membrane type, manufacturer, and the fouling status. Overall, the results of this study demonstrated that the integrated membrane system is a very effective and reliable process for water repurification.

Biotechnology↗

Methadone maintenance treatment of narcotic addiction: a unit of medical care based on over 50,000 patient treatment years.

The experience with methadone maintenance treatment by two major New York City methadone maintenance treatment programs using the Dole-Nyswander philosophy is reviewed. After more than 56,000 person-years in treatment over a 10-year period of time, a unit of medical experience exemplified by these two programs is evident. There was a high degree of patient acceptance, a small amount of recognized residual illicit drug abuse, and steeply reduced criminal activities of those patients who remained in treatment. A wide variety of other methadone treatment programs are recognized. Many use methadone differently from those in the present study. The treatment results reported herein may represent a standard by which narcotic (methadone and other) treatment programs can be assessed.

Crime↗