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Biomedical subjects

R Tscholl

Publications and source records attributed to R Tscholl.

At least 37 records · Page 2Linked to original sources
PubMed1987

Adjuvant intravesical chemotherapy of superficial bladder cancer with monthly doxorubicin or intensive mitomycin. A comparison of two consecutive series.

120 patients with the first occurrence of TNM stage Ta or T1 bladder carcinoma were given adjuvant intravesical treatment in 2 consecutive series. The first 60 received doxorubicin monthly for 6 months, then on the 9th and 12th month following surgery. The second series was given mitomycin weekly for 2 months, then monthly to the end of the first year. Median follow-up is 48 months in the first series and 15 in the second. In the doxorubicin group, 28 patients had recurrences. The recurrence rate is 1.86/100 patient-months. Seventeen of these first relapses occurred within the first year. In the 'intensive' mitomycin series, where 36 patients were observed for 12 months or more, 3 relapsed. The recurrence rate to date is 0.35. The relapse-free survival probability at 12 months is 75% in the first series and 93% in the second. Treatment was stopped due to toxicity in 4 patients in the doxorubicin group and in 10 of the mitomycin group.

Administration, Intravesical↗
PubMed1986

The effects of renal pelvic pressure elevation on isotope nephrography and renal transit time, an experimental study.

Radionuclide procedures are clinically used for assessing obstruction in dilated urinary tracts. The precise correlation of the isotope retention function with the level of the renal pelvic pressure is not known as yet. It was measured experimentally using 20 minipigs. By means of ureterostomies in situ reaching into the pyelon the 40 kidneys were subjected to varying pressures (seven to 62 cm. H2O) while the renal processing of 123-I-orthoiodine-hippuric-acid was recorded. The correlation of five radionuclide parameters with the pelvic pressure was computed: the time to the peak value of the isotope nephrography (t-max) and renal transit time correlated very well with high grade pelvic pressure (greater than 37 cm. H2O): r = 0.91 and 0.86 respectively, but much less well with low grade pelvic pressure (less than 37 cm. H2O): r = 0.73 and 0.62 respectively. The slope of the third phase of the isotope nephrography (tan-turn) and the time to the turning point of its tangent (t-turn) correlated only weakly with elevated renal pelvic pressure: r = 0.62 and 0.59 respectively. In conclusion, radionuclide procedures give excellent qualitative information on the level of pelvic pressure. They cannot, however, be used even as an indirect means for quantitatively assessing elevated renal pelvic pressure, which in urinary obstruction is thought to be one of the factors jeopardizing renal function.

Animals↗
PubMed1985

Renal replantation (orthotopic autotransplantation) for echinococcosis of the kidney.

Ex vivo surgery with replantation of the kidney into the renal fossa was used to treat a centrally located renal hydatid cyst in a 44-year-old patient. The replanted kidney showed good urographic function 2 months postoperatively. Orthotopic replantation of the kidney into its original location is preferred to heterotopic autotransplantation into the groin.

Adult↗
PubMed1983

[Injuries of the membraneous urethra in children. 2 case reports and analysis of the literature].

Two cases of total disruption of the membraneous urethra in boys, 4 years of age, are reported. This experience and the literature suggest that a totally ruptured urethra should be realigned and the bladder drained by way of a suprapubic cystostomy. Urinary extravasation causes severe pelvic fibrosis with stricture or even closure of the urethra in children. The best procedure for similar adult cases, namely resection of the fibrosis and stricture with direct anastomosis of the intact urethra, is also best in pediatric cases.

Age Factors↗
PubMed1982

[Association of filiform hematomas of the nails and Raynaud's syndrome].

Two men (non smokers) suffer from unilateral Raynaud's phenomenon, as well as homolateral splinter hemorrhages of the nails. One of the patients has digital artery obstruction, confirmed angiographically. The other patient, in whom a thoracic outlet syndrome was diagnosed, suffers of cold-induced vascular spasm. The incidence, significance and etiology of splinter hemorrhages are discussed.

Hematoma↗
PubMed1980

Electroresection of the prostate in patients treated with heparin.

A comparison was made of blood loss under controlled heparinization and that occurring under normal conditions during electroresection of the prostate. Mean blood loss in patients treated with heparin amounted to 429.4 +/- 524.8 ml. and in the control group it was 391.8 +/- 451.4 ml. The difference is not significant. Therefore, a transurethral operation does not require interruption of anticoagulation therapy in cardiovascular patients.

Anticoagulants↗
PubMed1979

[Renal hypothermia in situ. Comparison between surface and perfusion cooling concerning renal function in pigs (author's transl)].

There are 2 competing methods for cooling the kidney in situ during surgical ischemia: from without by applying ice to the renal surface and from within by perfusing the renal artery. The latter procedure is said to be superior in protecting renal function. Herein the protective effect on renal function of both methods are compared. Pigs of 15--25 kg weight underwent nephrectomy on one side. The remaining kidney was subjected to cold ischemia during 90 minutes while perfusion- or surface cooling was performed. For perfusion cooling the aorta was punctured and the catheter introduced into the renal artery. The perfusing liquid consisted of a physiologic electrolyt solution (Ringer-Lactate) with heparin kept at a temperature of 3--5 degrees C. The initial perfusion lasted 10 minutes and resulted in a median renal core temperature of 23 degrees C. Then the kidney was put on a cooling pad and every 15 minutes again perfused for one minute. For surface cooling sterile melting ice made of glucose solution 5% was applied directly to the kidney. The renal core temperature could be kept at 15--20 degrees C. The two methods of hypothermia were judged by comparing the serum creatinine levels and the I131-hippuran clearances one month after surgery. There was no difference whatever as analysed by the t-test. Hypothermia by applying ice to the renal surface therefore proved to be equivalent to hypothermia by perfusion. Moreover it is much simpler.

Animals↗
PubMed1977

Ileal substitute of ureter with reflux-plasty by terminal intussusception of bowel: animal experiments and clinical experience.

The conflicting results reported after substitution of the ureter by isolated bowel segments suggest that the procedure is still hazardous. This induced us to check experimentally the performance of the ileal ureter with antireflux-plasty before using it clinically. The antireflux mechanism is constructed by intussuscepting the terminal 8 cm. of an isolated ileal segment into each other thus forming a nipple. After vesicoileostomy the nipple protrudes into the urinary bladder. In the pig vesicoileorenal reflux was prevented, and anterograde urinary flow from the kidney through the ileal ureter into the bladder was unobstructed. Finally, the case of a patient is recorded who was submitted to the same procedure successfully.

Animals↗
PubMed1977

Continent cecoileal conduit: preliminary report.

A continent cecoileal conduit to improve rehabilitation after external urinary diversion is described. The isolated cecum functions as a reservoir. The continence mechanism is constructed by intussuscepting the terminal ileum into the isolated cecum to form a nipple, preventing leakage of urine. The kidneys are protected from cecoureterorenal reflux by ureterocecostomies with submucous tunnels. We have used this technique on 4 patients, 2 of whom need no external urinary pouch since the urostoma is absolutely continent. One patient became incontinent 3 months postoperatively and is wearing a conventional bag and 1 patient died. There is no refluex into the kidneys. The upper urinary tract, which is dilated slightly 4 weeks postoperatively, tends to become normal after a few months.

Cecum↗
PubMed1977

Recording of vesical voiding pressure by means of CO2-perfusion.

By means of a CO-2-cystometer, carbon dioxide is introduced through a urethral catheter (F5) into the full urinary bladder while the subject is urinating around the catheter. A reproducible pressure curve can be recorded. The pressure values measured by CO2-perfusion correlate very well with those measured simultaneously by a conventional fluid method. It can be statistically demonstrated that the CO2 flowing into the bladder does not influence the vesical voiding pressure. It is concluded that the vesical pressure during micturition can be accurately recorded by CO2-perfusion.

Carbon Dioxide↗
PubMed1976

[Heart enlargement and arterial hypertension in renal arteriovenous fistula].

In a patient hospitalized for progressive congestive heart failure the findings were hypertension, cardiomegaly and a mass in the left upper abdomen. A murmur was audible over the tumor. Clinical suspicion of a renal newgrowth with an arteriovenous fistula was confirmed by renal angiography. After nephrectomy the heart size became normal but the hypertension could only be controlled by drugs. The causes, symptoms and signs, and pathophysiology of arteriovenous shunts are discussed. Therapy is surgical. Surgery eliminates the congestive heart failure.

Adenocarcinoma↗
PubMed1976

Investigation of urine transport in the ureter of the pig by x-ray videodensitometry. I. The effect of increasing diuresis on velocity and rhythm of contractions: relationship between pressure wave and urine bolus.

The flow rate is the decisive parameter of ureteric function. The frequency and the velocity of the contraction waves can be measured by X-ray videodensitometry without having to touch the ureter. The relationship between flow rate (milliliters per minute) and wave velocity (millimeters per second) is investigated in the pig ureter. It can be demonstrated that the wave velocity is a quadratic function of the perfusion. The graphic representation of this function corresponds ot a parabolic curve. The relationship between the bolus and the pressure wave is analyzed and it is shown that the time lag between the rear end of the bolus and the pressure peak is independent of the wave velocity. The theoretical ureter model of Weinberg is experimentally confirmed by simultaneous manometry and videodensitometry.

Absorptiometry, Photon↗