Biomedical subjects

R Uddman

Publications and source records attributed to R Uddman.

171 records · Page 10Linked to original sources

PubMedDate not supplied

Innervation of the feline eustachian tube.

The distribution of adrenergic, cholinergic and peptidergic nerves in the feline eustachian tube was studied using histochemical techniques. Adrenergic, acetylcholinesterase-positive and vasoactive intestinal polypeptide immunoreactive nerves were numerous in the tubal wall. All three types of nerve fibers occurred in the subepithelial layer, around small blood vessels and around the acini of seromucous glands. No nerves displaying substance P or enkephalin immunoreactivity were observed.

Acetylcholinesterase↗

PubMedDate not supplied

Autonomic innervation of the middle ear.

The distribution of nerve fibers in the middle ear mucosa and eardrum of the cat and guinea pig was studied using immunocytochemical and histofluorescence techniques. Nerve fibers containing noradrenaline, vasoactive intestinal peptide, substance P, enkephalin or immunoreactive avian pancreatic polypeptide were demonstrated in the middle ear mucosa. After extirpation of the superior cervical ganglion, nerve fibers containing noradrenaline and avian pancreatic polypeptide disappeared while fibers containing vasoactive intestinal peptide, substance P and enkephalin seemed to remain unaffected.

Adrenergic Fibers↗

PubMedDate not supplied

Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall.

Nerves displaying vasoactive intestinal peptide (VIP) immunoreactivity were detected in the upper respiratory tract of guinea pigs, rabbits and cats. VIP nerves were numerous in the cat, less numerous in the rabbit and rare in the guinea pig. In the nasal mucosa, fine varicose VIP nerves were found to surround nasal glands and small blood vessels. In the tracheobronchial wall VIP nerves were observed around seromucous glands, blood vessels and smooth muscle. Ganglia located in the walls of the trachea and main bronchi contained clusters of VIP immunoreactive nerve cell bodies, conceivably representing the origin of the VIP fibres found in this region.

Animals↗

PubMedDate not supplied

The elastic properties of the tympanic membrane system in divers and non-divers.

The volume/pressure relationship of the tympanic membrane system was studied in 24 scuba divers. The results were compared with the results obtained from 98 non-diving subjects. Among persons with a good function of the Eustachian tube, divers had an increased mobility of the tympanic membrane system as compared to non-diving subjects. Divers with a reduced function of the Eustachian tube did not differ from the non-diving subjects with a reduced tubal function. Factors that might influence the volume/pressure relationship of the tympanic membrane system are discussed.

Adult↗

PubMedDate not supplied

The origin of vasoactive intestinal polypeptide (VIP) nerves in the feline nasal mucosa.

The feline nasal mucosa is richly supplied with vasoactive intestinal polypeptide (VIP) immunoreactive nerve fibres. The nerves occur in the subepithelial connective tissue, around small blood vessels and around the acini of seromucous glands. The ptergopalatine ganglion contains numerous VIP immunoreactive nerve cell bodies among non-reactive ones. Extirpation of the ganglion results in an almost complete disappearance of VIP-containing nerves in the nasal mucosa, while sectioning of the preganglionic nerve (Vidian nerve) does not affect the number of nasal VIP nerves. Hence the bulk of VIP nerve fibers in the nasal mucosa derive from cell bodies located in the pterygopalatine ganglion.

Animals↗

PubMedDate not supplied

Effects of vasoactive intestinal polypeptide on resistance and capacitance vessels in the nasal mucosa.

Vasoactive intestinal polypeptide (VIP) immunoreactive nerves have previously been demonstrated in the feline nasal mucosa. In the present investigation it is shown that VIP given close arterially dilates both resistance and capacitance vessels in the nose of the cat. This vasodilatation is atropine resistant. It is suggested that VIP serves a physiological role in the neurogenic control of blood vessels in the nasal mucosa.

Animals↗

PubMedDate not supplied

The morphological basis for the effect of substance P on mucociliary activity in rabbit maxillary sinus.

The mucociliary (m.c.) activity in rabbit maxillary sinus is accelerated by the neuropeptide substance P (SP). The morphological basis for this mechanism was investigated by immunocytochemistry using monoclonal antibodies directed against SP. SP-like immunoreactivity was found in nerve fibres in the subepithelial layer of the sinus mucosa, in the maxillary nerve, and in nerve endings close to nerve cell bodies in the sphenopalatine ganglion. Thus, there is morphological evidence in the rabbit that SP plays a role in the regulation of m.c. activity. The results also support the view that the rabbit maxillary sinus is a suitable experimental model for studying SP effects in the airway mucosa.

Animals↗

PubMedDate not supplied

Fluorescamine in cytodiagnosis of thyroid carcinomas.

Fluorescamine, which reacts with primary amino groups yielding intensely fluorescent products, was found to induce intense fluorescence in cells from medullary and papillary thyroid carcinoma. No fluorescence was detected in cells from follicular or undifferentiated carcinoma or from benign thyroid lesions, except Hürthle cell adenomas, the cells of which exhibited moderate fluorescamine-induced fluorescence. This was demonstrated on fine needle aspiration biopsy smears pretreated with formaldehyde gas. Since the fluorescamine technique is simple and rapid, it may be of value as an aid in the cytodiagnosis of thyroid neoplasms.

Biopsy, Needle↗

PubMedDate not supplied

Fluorescamine as a cytochemical detection reagent for mammary carcinoma cells.

Fluorescamine is a versatile reagent for the cytochemical demonstration of primary amino groups. Following pretreatment with formaldehyde, only certain "protected" amino groups will react with fluorescamine. In the present study we show that compounds containing such amino groups are abundant in mammary carcinoma cells but undetectable in normal mammary gland cells. Most cytologically benign breast lesions are devoid of cells containing these compounds. Although much work remains to be done, the fluorescamine technique, which is rapid and simple to perform, may offer some help in the distinction between normal and malignant cells of the mammary gland.

Breast Diseases↗