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R Uusitalo

Publications and source records attributed to R Uusitalo.

34 records · Page 2Linked to original sources
PubMed1976

Blood-aqueous barrier in newborn and young rabbits. An electron microscopic study.

Distribution of intravenously injected horseradish peroxidase (HRP) in the ciliary body of newborn and young (2 weeks old) rabbits was studied with the electron microscope. The reaction product was localized in all animals in the lumen of the blood vessels, in the perivascular area, in the surrounding connective tissue stroma and also in the epithelial cell layers. The peroxidase penetrated through the intercellular junctions of the pigmented cells to the intercellular space between the apical membranes of the two epithelial cell layers. In young rabbits peroxidase penetrated between the apical intercellular clefts of the non-pigmented cells in small quantities only, whereas in the newborn animals the clefts were filled with peroxidase. This reflects differences in the blood-aqueous barrier mechanism between the two studied groups and is evidently due to developmental stages of the eyes.

Age Factors↗
PubMedDate not supplied

Compatibility of corticosteroids and antibiotics in combination.

PURPOSE: To study the compatibility of combinations of antibiotics and steroids commonly used in anterior segment surgery. SETTING: Research Laboratory, Helsinki University, Finland. METHODS: Aggregate production in vitro and in vivo was studied for three injectable antibiotics (cefotaxime sodium, tobramycin sulfate, and gentamicin) and four corticosteroids (triamcinolone acetonide, methylprednisolone sodium succinate, methylprednisolone acetate, and dexamethasone sodium phosphate) using conventional and dark-field microscopy. Aggregate formation on collagen shields and subconjunctival aggregate formation of tobramycin sulfate in combination with methylprednisolone acetate or dexamethasone sodium phosphate was also studied. RESULTS: Dexamethasone sodium phosphate (4 mg/mL) did not form aggregates with any of the three antibiotics tested. Cefotaxime sodium did not cause aggregates when 24 mg/mL of dexamethasone sodium phosphate was used both in vitro and in vivo or in association with collagen shields. CONCLUSIONS: To avoid undesired side effects, such as epithelial sloughing and corneal edema after collagen shield application, antibiotics and steroids must be carefully selected.

Animals↗
PubMedDate not supplied

Particulate phosphorus and sediment in surface runoff and drainflow from clayey soils.

Recent work has shown that a significant portion of the total loss of phosphorus (P) from agricultural soils may occur via subsurface drainflow. The aim of this study was to compare the concentrations of different P forms in surface and subsurface runoff, and to assess the potential algal availability of particulate phosphorus (PP) in runoff waters. The material consisted of 91 water-sample pairs (surface runoff vs. subsurface drainage waters) from two artificially drained clayey soils (a Typic Cryaquept and an Aeric Cryaquept) and was analyzed for total suspended solids (TSS), total phosphorus (TP), dissolved molybdate-reactive phosphorus (DRP), and anion exchange resin-extractable phosphorus (AER-P). On the basis of these determinations, we calculated the concentrations of PP, desorbable particulate phosphorus (PPi), and particulate unavailable (nondesorbable) phosphorus (PUP). Some water samples and the soils were also analyzed for 137Cs activity and particle-size distribution. The major P fraction in the waters studied was PP and, on average, only 7% of it was desorbable by AER. However, a mean of 47% of potentially bioavailable P (AER-P) consisted of PPi. The suspended soil material carried by drainflow contained as much PPi (47-79 mg kg-1) as did the surface runoff sediment (45-82 mg kg-1). The runoff sediments were enriched in clay-sized particles and 137Cs by a factor of about two relative to the surface soils. Our results show that desorbable PP derived from topsoil may be as important a contributor to potentially algal-available P as DRP in both surface and subsurface runoff from clayey soils.

Agriculture↗
PubMedDate not supplied

Improvement of the recurrence-free interval using biological adjuvant therapy in uveal melanoma.

This study was an attempt to compensate for an alleged aetiological deficiency in melanoma by the prophylactic oral administration of the essential biological components missing. Nine random patients suffering from high-risk uveal melanoma (T3) were, in this preliminary study, treated secondarily with biological dietary adjuvants after primary standard therapy, enucleation or brachytherapy. Secondary treatment consisted of certain natural amino-acids, trace-element salts, folic acid and a diet containing neurogenic lipid components. It entailed no side-effects, no toxicity and was inexpensive. None of these nine patients has suffered recurrent disease. The mean follow-up time was over 80 months (median 69, range 58-140 months). Local tumour control was 100%. This clinical result is significantly better (p = 0.018) as compared to similar T3 uveal melanoma patients in standard care who did not receive adjuvant dietary remedies after primary treatment. The control patients consisted of similar adjusted T3 cases selected from the Swedish official registries, and T2 patients from Germany. Based on the previous positive clinical results obtained with cutaneous malignant melanoma in bioimmunotherapy this additional positive result supports the notion that biological components administered orally may compensate for the etiological deficiency leading to malignant melanoma.

Administration, Oral↗