PubMed Health⌕ Search

Biomedical subjects

R V Heatley

Publications and source records attributed to R V Heatley.

At least 145 records · Page 8Linked to original sources
PubMed1977

The effects of splenectomy, mesenteric lymphadenectomy and portacaval shunt on antibody responses to antigens within the small intestine.

The primary and secondary systemic antibody responses to protein antigens introduced into the gut (diphtheria toxoid, lauroylated human serum albumin) were not diminished or enhanced by previous splenectomy, mesenteric lymphadenectomy or portacaval shunt. Immunization with diphtheria toxoid before such operations did not produce significant alterations in the responses. The cells forming antibody were found predominantly in the lamina propria of the small bowel and to a lesser extent in the subcapsular sinuses of the mesenteric lymph nodes when tissues were examined by the fluorescent antibody technique, ten days after the secondary stimulus of intestinal diphtheria toxoid. The experiments show that the responses, stimulated locally by gut absorbed protein are little affected by an altered portal circulation.

Animals↗
PubMed1976

Preoperative or postoperative deep-vein thrombosis?

The incidence of deep-vein thrombosis as detected by the 125I-fibrinogen test and confirmed by phlebography was 32% in a high-risk group of patients admitted to hospital more than 4 days before operation. 62% of these thrombi were established before operation. Patients with malignant disease and those receiving preoperative intravenous nutrition were particularly prone to this complication. Recognition that asymptomatic thrombosis may be present before operation helps to clarify many of the enigmatic aspects of this condition, and has important implications for the interpretation of the results of clinical trials of prophylaxis. The condition should be suspected in patients transferred for surgery from medical wards, and prophylactic measures should be commenced at the time of admission in high-risk patients.

Adult↗
PubMed1975

Immunoglobulin E in rectal mucosa of patients with proctitis.

Rectal-biopsy specimens were obtained from a group of patients with proctitis in different stages of activity. Large numbers of brightly fluorescent IgE-producing cells were demonstrated in rectal-biopsy specimens taken from these patients during disease activity and clinical remission. An immediate hypersensitivity reaction is suggested as one of the mechanisms involved in the pathogenesis of proctitis.

Biopsy↗
PubMed1975

Acute folate deficiency in surgical patients on aminoacid/ethanol intravenous nutrition.

Acute folate deficiency with pancytopenia and megaloblastic haemopoiesis developed in four patients after abdominal operations; all four responded to folic acid over 3-9 days. Three of them had been given intravenous nutrition with amino-acid/ethanol before the blood changes developed. A prospective study of twenty-five surgical patients with gastrointestinal diseases revealed a high frequency of acutely developing negative folate balance. Megaloblastic haemopoiesis and consequent blood changes were found in five patients. Treatment with intravenous nutrition correlated strongly with a fall in serum-folate and megaloblastic haemopoiesis. Some surgical patients develop acute folate deficiency which may proceed to megaloblastic arrest of haemopoiesis. Patients receiving intravenous nutrition containing ethanol are especially prone to this complication, which may be life-threatening if untreated. It is not yet known whether other forms of intravenous nutrition carry a similar risk.

Acute Disease↗
PubMed1975

A search for a transmissible agent in Crohn's disease.

Controversy exists as to whether a transmissible agent is responsible for Crohn's disease. Previous reports have suggested that sarcoid-like granulomas can develop in animals following inoculation of homogenates derived from bowel affected by Crohn's disease. This study involved the injection of Crohn's tissue homogenates into experimental animals under a variety of conditions which might be expected to favour the demonstration of such an agent. Homogenates have been inoculated into the ileum of rats, mice, and rabbits and also given inoculated into ileum and footpads of rats which have previously been rendered lymphoedematous by surgical interruption of the draining lymphatics. Bowel homogenates from a total of 17 patients with Crohn's disease have been injected into 91 experimental animals. No macroscopic or microscopic changes indicative of Crohn's disease were detected. Thus study does not support the suggestion that a transmissible agent is present in Crohn's disease.

Animals↗
PubMed1975

Disodium cromoglycate in the treatment of chronic proctitis.

The effect of topical disodium cromoglycate (DSCG) has been examined in 30 patients with chronic active proctitis using a double-blind crossover trial. Each treatment period was four weeks and patients were given DSCG 200 mg by enema twice daily and 100 mg orally three times each day. Twenty-six patients completed the trial successfully, 14 responded to DSCG treatment, two improved with placebo, and 10 responded to neither. Patients who responded to DSCG had significantly more eosinophils in their rectal biopsies than those who failed to respond and in some instances the counts were very high. The findings support the hypothesis than an allergic reaction is important in the pathogenesis of proctitis.

Adolescent↗
PubMed1975

Immunogenicity of lipid-conjugated protein in the intestine.

Acylation of human serum albumin increases its ability to stimulate antibody formation in rats. This can be shown not only when the antigen was given intramuscularly but also when administered by injection into the lumen of the gut. A tendency of the modified molecules to attach to cells and to aggregate, increased anti-complementary activity, and reduced drainage through the lymphatics, have been demonstrated. The relationship of these features to the increased immunogenicity is discussed.

Acylation↗