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Biomedical subjects

R V Henrickson

Publications and source records attributed to R V Henrickson.

At least 37 records · Page 2Linked to original sources
PubMed1982

Response of thyroxine and triiodothyronine to thyroid-stimulating hormone in adult female baboons (Papio cynocephalus).

The thyroxine (T4) and triiodothyronine (T3) response of the female baboon to injection of exogenous thyroid stimulating hormone was studied. This response established reference values for baseline and post-stimulation serum levels of T4 and T3. The reference values for T4 and T3 by radioimmunoassay were 9.9 +/- 2.2 micrograms/dl and 121 +/- 18 ng/dl, respectively. The T4 response to thyroid-stimulating hormone reached its peak level of 22.7 +/- 1.8 micrograms/dl at 12 +/- 2.5 hours. The corresponding peak response for the T3 was 351 +/- 61 ng/dl which occurred at 8.0 +/- 2.5 hours. The T3 response was more rapid and reached its peak earlier than T4.

Animals↗
PubMed1981

An epidemiological survey of wild caught and domestic born rhesus monkeys (Macaca mulatta) for Anatrichosoma (Nematoda: Trichinellida).

A group of wild caught rhesus monkeys and their domestic born infants were examined for Anatrichosoma, a nematode that inhabits the nasal mucosa and subcutaneous tissue of the face, hands, and feet. The diagnosis was made using nasal swabs. Fifty-four percent of the wild caught animals reported positive ina survey taken 3 years earlier were negative based upon results of reexamination, while one animal was found positive that had been reported negative. None of the infants examined had positive samples for Anatrichosoma.

Animals↗
PubMed1980

Yersinia pseudotuberculosis infection in a group of Macaca fascicularis.

Diarrheal disease associated with abortions and stillbirths occurred in a group of 42 Macaca fascicularis. The group was composed of wild-caught adults and their colony-born offspring housed in a half-acre cage. Thirteen adult females and 1 infant male were affected. All 14 monkeys had diarrhea and all 9 pregnant females either aborted or had a stillbirth. Yersinia pseudotuberculosis was isolated from 7 animals. In addition, Y enterocolitica was isolated from 1 monkey and Shigella flexneri type IV was isolated from 5 monkeys. One adult female had a mixed infection of both Y pseudotuberculosis and S flexneri. Every pregnant monkey from which Y pseudotuberculosis was isolated aborted or had a stillbirth. Five animals died, and Y pseudotuberculosis was the only pathogen isolated from these 5 monkeys.

Abortion, Veterinary↗
PubMed1980

Microscopic examination of stools from nonhuman primates as a way of predicting the presence of Shigella.

Microscopic examination of stool samples from captive nonhuman primates with diarrhea for the presence or absence of leukocytes or erythrocytes or both as a means of predicting the presence of Shigella spp. was performed. Analysis of the data multivariately by means of a log linear model did not show a three-way association between diarrhea, Shigella, and the presence or absence of cells.

Animals↗
PubMed1980

A survey for intestinal helminths in recently wild-caught Macaca mulatta and results of treatment with mebendazole and thiabendazole.

One hundred Macaca mulatta, trapped in India and transported directly to the California Primate Research Center, were surveyed for the prevalence of gastrointestinal helminths. Trichostrongylus sp. was found in 86% of the animals, followed by Strongyloides fulleborni (63%), Streptopharagus sp. (38%), Oesophagostomum sp. (23%) and Anatrichosoma sp. (21%). Treatment with mebendazole and thiabendazole was efficacious against all the intestinal nematodes, with the exception of mebendazole versus Streptopharagus sp.

Animals↗
PubMed1980

Effects of ketamine hydrochloride on the hemogram of rhesus monkeys (Macaca mulatta).

Ketamine hydrochloride administration altered the hemogram of rhesus monkeys when compared to physical restraint for venipuncture. The alterations were decreases in the leukocyte count, total plasma proteins, and hematocrit. The decrease in the leukocyte count was due primarily to a decrease in lymphocytes with a smaller decrease in neutrophils.

Animals↗
PubMed1979

A survey for Anatrichosoma (Nematoda: Trichinellida) in wild-caught Macaca mulatta.

One hundred rhesus monkeys which were captured from two geographical sites were tested for Anatrichosoma, a nematode that lives in the nasal passages. The monkeys were tested using both fecal examinations and nasal swabs. Three percent of the monkeys from one site were positive, and 68% from the other site were positive. Twenty-one percent of the animals tested by fecal examination were positive and 48% were positive using nasal swab examination.

Animals↗
PubMed1979

Virus detection in monkeys with diarrhea: the association of adenoviruses with diarrhea and the possible role of rotaviruses.

To explore the role of viruses in the etiology of diarrhea in colony-reared monkeys, direct electron microscopy, the fluorescent virus precipitin test and cell culture inoculation were used to examine the stools of monkeys with and without diarrhea. The animals were predominantly rhesus with a few macaques of other species, and included infants, juveniles and adults. Adenoviruses were isolated from a higher proportion of specimens from rhesus monkeys with diarrhea (73% of specimens from infants and 78% of specimens from juveniles and adults) than from control monkeys without diarrhea (22% of specimens from infants and 26% of specimens from juveniles and adults). SV 20 was the most frequently isolated simian adenovirus type; SV 17 and SV 32 also were recovered. Noncultivable adenoviruses detectable only by electron microscopy were not seen. Although adenovirus excretion was associated with diarrhea, the causal role of adenoviruses was difficult to assess. When serial specimens from animals with chronic or intermittent episodes of diarrhea were examined, sequential infections with different viruses were found to be common. Rotaviruses were detected by electron microscopy and isolated in cell cultures from two infant rhesus monkeys with diarrhea. However, the low detection rate, together with negative serologic data on 40% of infant monkeys with diarrhea, suggested that rotaviruses were not the major cause of gastroenteritis in the monkeys under study.

Adenoviridae↗
PubMed1979

Rotavirus antibody assays on monkey sera: a comparison of enzyme immunoassay with neutralization and complement-fixation tests.

An enzyme immunoassay (EIA) for the detection of rotaviral antibodies was developed, using a purified, cell culture-grown SA 11 viral antigen and alkaline phosphatase as an enzyme label. This technique was evaluated by comparative testing with tube neutralization and complement-fixation assays on a collection of simian sera. There was close correlation between positive and negative results obtained by EIA and by neutralization. The EIA was as easy to perform as complement fixation testing, but showed greater sensitivity and fewer nonspecific reactions. Thus, EIA was shown to be a very suitable test for routine detection of rotaviral antibodies in serum. Results of neutralization tests suggested that the monkeys (mostly rhesus macaques) in the present study were infected with viruses varying in their antigenic relatedness to SA 11 virus and to a British isolate of calf rotavirus.

Animals↗
PubMed1977

Polyclonal gammopathies associated with chronic diseases in nonhuman primates.

Serum samples collected from clinically healthy rhesus macaques (Macaca mulatta) were compared with serums from animals diagnosed as having malignant lymphoma, atypical tuberculosis, progressive multifocal leukoencephalopathy, or more than 1 of these. Electrophoretic analyses of serum proteins (in grams per deciliter) indicated that mean values in a clinically normal group were as follows--total protein, 8.30; albumin, 4.07; alpha-globulin, 0.85; beta-globulin, 2.23; and gamma-globulin, 1.15. In macaques with malignant lymphoma, mean values were--total protein, 7.60; albumin, 2.72; alpha-globulin, 0.91; beta-globulin, 1.71; and gamma-globulin, 2.23. In macaques with atypical tuberculosis, these values were 8.47, 2.92, 0.84, 2.18, and 2.52, respectively, and those with progressive multifocal leukoencephalopathy, 9.06, 4.01, 6.71, 2.42, and 1.93. Where multiple serum samples were available from 1 macaque for analysis, gamma-globulin values were increased before clinical disease was apparent. Evaluation of serums from macaques may be used as a means of detecting preclinical lymphoproliferative disease.

Animals↗
PubMed1975

Ketamine immobilization of northern elephant seals.

Ketamine was used as an immobilizing agent to obtain biological specimens from northern elephant seals in their natural habitat. Effective immobilization was achieved with dosages of 1.4 to 6.9 mg/kg of body weight.

Animals↗
PubMed1975

Mycobacterium avium infection in three rhesus monkeys.

Naturally occurring Mycobacterium avium infection in 3 rhesus monkeys was characterized clinically and pathologically by intestinal and lymphoreticular involvement. Blood lymphocyte rosette formation and phytomitogen responses were depressed, whereas serum beta and gamma globulin concentrations were increased. Slow-growing, acid-fast, nonchromogenic bacilli isolated from lymph nodes taken at necropsy were identified as M avium serotypes 4, 18, and double types 1 and 8.

Animals↗
PubMed1975

Coccidioidomycosis in a rhesus monkey.

Coccidioidomycosis was diagnosed after necropsy of a young adult male rhesus monkey obtained from El Paso, Tx. Clinical signs were confined to the respiratory tract and included tachypnea and dyspnea. Radiographic findings included multiple air-filled cavities and evidence of severe diffuse pulmonary disease. Pathologic changes were confined to the respiratory tract and were representative of the chronic progressive pulmonary form of coccidioidomycosis. Unique features of this case were the massive involvement of the pulmonary parenchyma, the formation of multiple miltiloculated cavities that arose from conducting airways, and the metaplastic epithelial changes within the cavities. Histologic examination revealed numerous spherules characteristic of Coccididioides immitis but an absence of mycelial forms.

Animals↗
PubMed1975

Infant mortality in Macaca mulatta: neonatal and post-neonatal mortality at the California Primate Research Center, 1968-1972. A retrospective study.

Seven hundred forty-two Macaca mulatta births were recorded at the California Primate Research Center, 1968-1972. The neonatal mortality rate (deaths smaller than or equal to 30 days of age) was 10.8%, and the post-neonatal mortality rate (deaths at 31-183 days) was 6.9%. The neonatal mortality rate was higher in outdoor group cages than in indoor individual cages (24.8 vs. 8.0%). The post-neonatal mortality rate was also higher outdoors than indoors (15.9 vs. 5.9%). Outdoor mortality showed apparent seasonal variation, while indoor mortality did not.

Age Factors↗