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Biomedical subjects

R Vander Griend

Publications and source records attributed to R Vander Griend.

6 recordsLinked to original sources
PubMed1999

Evaluation of ankle instability using the Biodex Stability System.

Ten patients with chronic unilateral functional lateral instability of the ankle were evaluated using the Biodex Stability System. This system uses a multiaxial testing platform which can be set at variable degrees of instability. Patients are then tested for their ability to "balance" the platform during single-limb stance, and a stability index is electronically generated. This stability index is believed to be an objective measurement that correlates with proprioceptive status of the ankle. Instability of the ankle was confirmed in all 10 patients, using stress radiographs. Two levels of platform stability were tested. With the platform in its most stable configuration, there was minimal difference between the previously injured and the uninjured ankle. With the platform set to permit up to 20 degrees of tilt in any plane, 6 of 10 patients had more difficulty balancing the platform with their injured ankle (higher stability index). This preliminary study suggests that the Biodex Stability System may be a useful tool in trying to objectively measure proprioceptive function.

Adult↗
PubMed1990

Response of osteogenic sarcoma to the combination of etoposide and cyclophosphamide as neoadjuvant chemotherapy.

A Phase II study of the combination of etoposide (VP-16) and cyclophosphamide (CPM) was conducted in an attempt to identify active and potentially less toxic agents for treating patients with osteogenic sarcoma (OS). VP-16 was given as a 72-hour infusion for a total dose of 600 mg/m2. CPM was given as six pulses of 300 mg/m2 every 12 hours for a total dose of 1800 mg/m2. Seventeen newly diagnosed patients, including five (29%) with metastatic disease, were evaluated before and after two courses of VP-16 and CPM for clinical, radiologic, and biochemical (serum alkaline phosphatase [SAP]) responses of the primary tumor and metastases. Fifteen (88%) patients achieved complete or partial clinical responses. Fourteen (82%) patients achieved radiologic responses. Thirteen (87%) of 15 patients with higher than normal SAP levels for their age showed partial or complete responses. Three (60%) of the five patients with metastatic disease achieved complete or partial responses. The only major toxicity was myelosuppression, which led to 21 (62%) brief admissions after 34 courses of chemotherapy for intravenous antibiotic therapy for fever and neutropenia, without associated mortality. It was concluded that the combination of VP-16 and CPM is effective chemotherapy for both primary and metastatic OS. Although myelosuppression is inevitable, it is rapidly reversible in the drug dosages used. Further studies are needed to evaluate the effect of these drugs in combination with established agents in improving the disease-free survival of patients with OS.

Adolescent↗
PubMed1986

Gunshot fractures.

Explore the source record for details and available documents.

Fractures, Bone↗
PubMed1986

Open reduction and internal fixation of humeral shaft fractures. Results using AO plating techniques.

Thirty-six patients with an acute fracture of the humeral shaft were treated by open reduction and internal fixation using AO plating techniques. In thirty-two patients an open fracture or multiple injuries, or both, were the indications for internal fixation. Four patients were treated after non-operative treatment failed to maintain a satisfactory reduction. Follow-up was possible for thirty-four patients and showed that thirty-three fractures united primarily and one failed to unite, necessitating two subsequent procedures. Two superficial wound infections in patients with an open fracture and one transient postoperative radial-nerve palsy were the only complications. A functional range of motion in the elbow and shoulder was regained in all but six patients, and they had severe skeletal or soft-tissue injuries in the same extremity. When indicated, internal fixation using plating techniques can give good results provided the correct principles of fixation are carefully followed.

Adolescent↗
PubMed1983

Arthrodesis of the knee with intramedullary fixation.

The application of intramedullary fixation for arthrodesis of the knee has been limited by the technical problems of rod failure and fracture of the femur at the rod insertion site. Improved implant design and rod insertion technique were utilized in seven patients with uniformly successful results. Intramedullary fixation provides prolonged stable fixation and is an alternative to the external fixation techniques currently used to achieve knee arthrodesis.

Adult↗