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R Vela-Navarrete

Publications and source records attributed to R Vela-Navarrete.

18 recordsLinked to original sources
PubMed2000

Age-stratified analysis of I-PSS and QoL values in spanish patients with symptoms potentially related to BPH.

OBJECTIVE: The main goal of the present study was to determine age-related symptom changes using a validated Spanish International Prostate Symptom Score (I-PSS) and quality of life index (QoL) in Spanish patients with symptomatic benign prostatic hyperplasia (BPH). METHODS: A total of 2,875 patients with the clinical diagnosis of symptomatic BPH were evaluated. Data were collected during current medical practice in a national study. Patients were excluded if they had any previous prostate operation or suspicion of prostate cancer. I-PSS was self-administered and compared with the physician's global impression. RESULTS: I-PSS symptoms, both voiding and storage symptoms, increased significantly with age (p<0.0001) as well as QoL (p<0.0017). A change in the I-PSS categories (minor, moderate and severe) was found with age, increasing severe symptomatic patients in the oldest groups. A significant correlation was found between I-PSS and QoL (r = 0.49, p<0.001), being this relationship linear and not significantly influenced by age. CONCLUSIONS: This study confirms reliable results using a validated Spanish I-PSS in a large national representative sample of Spanish patients with BPH symptoms. The age-stratified analysis showed that the natural progression of BPH with age was related to an increased symptomatology and bothersomeness, well reflected by increases in the I-PSS and QoL values. Nevertheless, the effect of symptomatology on quality of life was not strongly influenced by the age of the patient.

Age Factors↗
PubMed1998

Characterization of the muscarinic receptor mediating contraction of the dog prostate.

1. We have studied the effects of muscarinic cholinoceptor agonists and subtype-preferring antagonists on the isometric contraction of smooth muscle strips from dog prostate. 2. Acetylcholine and carbachol induced contraction of prostate strips from the peripheral zone, ('the capsule'). Bethanechol contracted the tissue but not at lower doses. McN-A-343 and oxotremorine-M showed the same effects. 3. Blocking alpha- and beta-adrenoceptors with phentolamine and propranolol, respectively, did not modify carbachol-induced contractions. 4. The nicotinic receptor blocker, hexamethonium (10(-6)-10(-4) M) did not affect the contractile response evoked by a single dose of carbachol (10(-5) M), whilst the muscarinic receptor antagonist, atropine (10(-11)-10(-9) M), inhibited it in a competitive manner. 5. The muscarinic M1 (pirenzepine), M2 [AF-DX 116, himbacine (M2/M4) and methoctramine], M3 (HHSID and f-F-HHSID), and putative M4 (tropicamide) antagonists reduced significantly the carbachol-induced contractions. The pIC50 values were: atropine (10.01) > himbacine (8.3) > methoctramine (7.85) > AF-DX 116 (7.60) > HHSID (7.21) > p-F-HHSID (7.10) > pirenzepine (7.30) > tropicamide (7.00). 6. The antagonist profile indicates that an predominant M2 receptor subtype could mediate the muscarinic contraction in the canine prostate.

Acetylcholine↗
PubMed1988

Tolerance to bilateral subcutaneous access nephrostomy in dogs.

Subcutaneous nephrostomy is a technique which allows access to the renal pelvis for physiological study in the experimental animal over a prolonged period of time without the complications attendant upon an externally draining appliance. One end of an 8 Fr. polyvinyl tube was placed in the renal pelvis at open surgery and the other end was capped and buried in the subcutaneous space for subsequent access by percutaneous needle puncture. This procedure is preferable to surgically created vesical exstrophy, exteriorization of the renal pelvis or conventional nephrostomy, techniques which have been proposed for such purposes. Tolerance to subcutaneous access nephrostomy was investigated in a group of 10 dogs followed for periods ranging from six months to two years. It was found that bilateral subcutaneous access nephrostomy did not alter kidney function but was associated with altered peristalsis. It was also associated frequently with bacteriuria, but not pyelonephritis. Neither calcific deposits nor calculi were seen as a consequence of the tube, and the procedure was well tolerated by the animal although, in some, progressive weight loss was observed. In general, this technique proved to be an excellent procedure for prolonged physiological studies of the urinary tract in dogs, and might similarly find some clinical application in humans.

Animals↗
PubMed1984

[Urodynamic studies of the upper urinary tract. I. Introduction and diagnosis of the obstruction].

Present experience precludes any assertion as to what a urodynamic exploration of the upper urinary tract exactly comprises, and what the fundamental indications are, despite the many attempts already made, which the author recalls. After establishing the conceptual difference between obstruction and stasis, the author goes on to analyze the existing methods for identifying the existence of an obstruction in cases of chronic dilatation. Noninvasive methods, intravenous urography, diuretic urography, conventional and diuretic renography and analysis of the parenchymal transit time, are all probably successful in establishing the existence of an obstruction in 85 per cent of cases of chronic dilatation of the upper urinary tract; but these methods cannot be used to quantify the obstruction, or even identify it in certain specific cases. In order to quantify the obstruction, recourse must be had to invasive methods, and more particularly, in view of the limitations of basal and diuretic pyelomanometry, to combined pressure/flow studies. The author analyzes the two possibilities open for the application of these procedures (constant flow perfusion, or perfusion with a constant pressure) together with their advantages and drawbacks.

Adolescent↗
PubMed1983

Polycystic disease of the renal sinus: structural characteristics.

Based on a series of 32 identified cases the radiologic, sonographic and anatomic features of polycystic disease of the renal sinus are described. This entity is a bilateral accumulation of thin-walled clear fluid-filled cysts, intertwined with the caliceal infundibula and usually confused radiologically with adult polycystic kidney disease or with renal sinus lipomatosis. Computerized tomography and sonography demonstrate the parenchyma to be free of cystic disease and the hilus to be free of fat accumulation. This newly recognized entity has a completely benign natural history.

Humans↗
PubMed1982

Constant pressure flow-controlled antegrade pyelography.

Flow-controlled antegrade pyelography is performed by perfusion of contrast dye after transcutaneous puncture of the renal cavities. The procedure enables excellent visualization in cases of upper tract dilatation, when the result of high-dosis excretory urography is not satisfactory. Flow-controlled antegrade pyelography under constant pressure provides urodynamic support to pyelography because the flow rate is known during the procedure, facilitating the interpretation of the relation dilatation and flow in cases of upper tract equivocal obstruction. Perfusion under constant pressure enables the recognition of the resistance to flow of the pyeloureteral tract in a simple manner.

Dilatation, Pathologic↗
PubMed1980

What is a urodynamics study of upper urinary tract?

The urodynamic study of the upper urinary tract is a urologic procedure whose objective is to complement the information obtained by excretion urography in selected cases of documented or suspected upper tract obstruction. The procedure has several steps, all of which can be done by antegrade transcutaneous puncture of the kidney. The first and most important step consists of the simultaneous analysis of resting pelvic pressure, solute concentration in aspirated urine from the renal pelvis, and antegrade pyelogram. This set of data makes up the basic urodynamic evaluation and will be sufficient in many cases for diagnostic and prognostic purposes. However, in selected circumstances of equivocal dilatation or severe kidney atrophy, more complementary information can be gained using antegrade flow studies or temporary diversion by needle nephrostomy, respectively. These conclusions have been based on more than 300 urodynamic evaluations done by the author.

Humans↗