Biomedical subjects

R Verel

Publications and source records attributed to R Verel.

3 recordsLinked to original sources

PubMed2001

Fast MAS total through-bond correlation spectroscopy.

Mixing sequences for total through-bond correlation spectroscopy in solids (TOBSY) were developed. The motivation is the design of broadband, effective, and robust sequences adapted for "fast" MAS. Possible sequences with the desired Hamiltonian (the homonuclear isotropic J interaction) were identified using lowest order average Hamiltonian theory. Numerical simulations as a function of the MAS frequency were then employed to further characterize the performance. An experimental TOBSY spectrum of a uniformly (13)C-labeled decapeptide at 20 kHz MAS was obtained using one of the new sequences. The spectrum allows us to assign the (13)C resonances to the respective spin systems.

Journal Article↗

PubMed2001

Adiabatic dipolar recoupling in solid-state NMR: the DREAM scheme.

A theoretical treatment of the DREAM adiabatic homonuclear recoupling experiment is given using Floquet theory. An effective Hamiltonian is derived analytically and the time evolution of the density operator in the adiabatic limit is described. Shape cycles are proposed and characterized experimentally. Application to spin-pair filtering and as a mixing period in a 2D correlation experiment is explored and the experimental results are compared to theoretical predictions and exact numerical simulations.

Journal Article↗

PubMed1999

INADEQUATE-CR experiments in the solid state.

Through-bond connectivity can be probed by J couplings. For effective two-spin systems, the INADEQUATE experiment is highly valuable in liquid-state spectroscopy. It is the purpose of this Communication to show that in-phase INADEQUATE-CR spectra, where the intensity is concentrated in only one line of the J splitted doublet, can be obtained from solid-state samples. The problem of the cancellation of nonresolved multiplet lines, as experienced typically in INADEQUATE spectra in the solid, is resolved and the (13)C spectra become simpler because the number of resonance lines is reduced. Furthermore, a gain in signal intensity by 2 can, theoretically, be achieved. We limit the discussion to two-spin systems. In the present context, a two-spin system is defined considering the J coupling only. When the dipolar coupling is also taken into account, the two-spin system will usually become a many-spin system, but in the present context this is not relevant.

Animals↗