Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid-like purpura angiodermatitis were studied with current hemostasis parameters: (1) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and high molecular weight kininogen (HMWK) in their coagulation fraction. The results showed: (1) reactional thrombocytosis with morphologic changes; (2) increased levels of platelet circulating aggregates; (3) increased response of platelet aggregation to different agonists, especially at very low doses, and also when we used washed platelets resuspended in normal plasma; (4) delayed activation of the contact system; (5) decrease of the activity of the fibrinolysis activators; and (6) diminished function activity of the HMWK coagulation fraction. As a physiopathogenic hypothesis in these patients, there is a cutaneous pathology that could be entailed to these hematologic alterations of the platelet-HMWK-endothelial cells-kinins-coagulation-fibrinolysis system.

Adult↗

PubMed1990

[Fibrous hamartoma in childhood].

A new case of fibrous hamartoma of infancy is described as a benign but persistent soft-tissue tumor that appears during the first 2 years of life, as a rare condition. The histopathological study shows the three characteristic elements: fibrous, uni-locular adipose tissue and mixoid mesenchymal tissue. The histogenesis of this peculiar tumor is discussed.

Female↗

PubMed1989

Sleep and nighttime pruritus in children with atopic dermatitis.

The number of scratching episodes and average frequency with which they started during each sleep stage as well as the effects of nighttime pruritus on objective sleep parameters in nine children with atopic dermatitis were assessed in the sleep laboratory. Scratching episodes occurred during rapid eye movement (REM) sleep and non-REM (NREM) sleep. The largest average frequency corresponded to stage 1, followed by stage 2, REM sleep, stage 4, and stage 3. Sleep maintenance was markedly altered. Total sleep time decrease was related mainly to smaller amounts of stage 4 NREM sleep. REM sleep percentage of total sleep time was increased as compared with normal children of the same age. Furthermore, in six of nine patients REM sleep latency was found to be decreased.

Adolescent↗

PubMed1989

[Elastic nevi of a familial nature. Buschke-Ollendorf syndrome. Forme frustre?].

Four cases of "connective naevus" have been revised in a family, mother and her two daughters and son. The histology shows as principal characteristic hyperplasia, thickness and crossing disposition of elastic fibers, forming an image similar to the one of an "elastic naevus". Because of its familiar features and the absence of osteopoikilosis, we postulate a frustrate form of the Buschke-Ollendorf syndrome.

Adolescent↗

PubMed1988

[Inhibition of the function of the neutrophil granulocyte caused by autologous serum from patients with acne vulgaris].

Sixteen patients with acne vulgaris were studied. All patients had severe inflammatory lesions, nodulocystic and conglobata. Of them, 12 was male and 4 female, their age was between 16 and 24 years old. In all the cases laboratory test to evaluate chemotactic, nitroblue-tetrazolium and lysosomal activity of granulocyte were performed. The protocol included in vitro incubations with and without autologous serum for considered their action on the phagocytic cell. The results shows an inhibitory action of the autologous serum in chemotactic (d-mean, 34.25%; SEM, 2.39, p less than 0.01), nitroblue-tetrazolium test (d-mean, 21.06%; SEM, 2.85, p less than 0.05), and lysosomal activity (d-mean, 21.43%; SEM, 2.80, p less than 0.05). The authors suggest that granulocyte alterations that occur in inflammatory forms of acne vulgaris is a secondary phenomenon may be caused by seric IgE or vasoactive substances released during immune responses.

Acne Vulgaris↗

PubMed1988

[The function of the neutrophil granulocyte in acne vulgaris].

Twenty seven patients with acne vulgaris were studied. Of them, 10 had minimal lesions and 17 had severe inflammatory lesions: nodulocystic, and conglobata. NBT and lysosomal neutrophil function was performed. The results shows a significative decreased values for the three test in patients with inflammatory lesions compared to patients with non-inflammatory lesions. The values for chemotactic function was 56.23 and 93%, for NBT test 50.82 and 93% and for lysosomal activity 60.88 and 88.9%, respectively. The authors proposed that the altered in vitro neutrophil function is a secondary phenomenon caused by specific and non-specific immunologic factors that occur in patients with severe inflammatory acne vulgaris.

Acne Vulgaris↗

PubMed1988

[Immunological changes in common vitiligo].

Three theories have been mentioned so as to explain vitiligo: normal, autocytotoxic and autoimmune. In this work we study the cellular immune elements in normal vitiligo. Concerning the skin, there is an increase of Langerhans cells (p less than 0.001) en its activation (DR+) (p less than 0.001). Regarding the blood, there is an increase of T cytotoxic lymphocytes (p less than 0.001), T activated lymphocytes (DR+) (p less than 0.001) and B lymphocytes (p less than 0.01). Total T lymphocytes and T cooperators (CD4+) are not increased. These results suggest that immune mechanisms mediated by T cytotoxic lymphocytes may be the cause of the melanocytes destruction in normal vitiligo.

Adult↗

PubMed1986

[Analysis of circulating T-lymphocyte subpopulations with monoclonal antibodies in psoriasis].

Subsets of peripheral blood lymphocytes were studied by surface markers in 21 patients with psoriasis. 12 had active lesions and 9 had stable lesions. The number of T cells was estimated by indirect immunofluorescence with the monoclonal antibody OKT3. The number of T inducer cells was estimated with the monoclonal antibody OKT4. The number of the activated cell was estimated with the monoclonal antibody Edu I. The patients with psoriasis had decreased T cell number, decreased T inducer cell number and increased T activated cell number. The patients with active lesions had the most pronounced alterations of T cells subsets. In these patients was observed also a decreased inducer/T suppressor cell ratio. The results, that show alterations in T cell number and it ratio are not able to establish or clarify an inducer or suppressor T cell activity in the course of psoriasis. The number of T suppressor cells was estimated with the monoclonal antibody OKT8.

Adolescent↗

PubMed1986

[Lymphocyte subpopulations in alopecia areata].

Subsets of peripheral blood lymphocytes were studied in 19 patients with alopecia areata. The results shows: a decreased Tm/Tg ratio, decreased number of OKT4+ cells, increased OKT8+ cells, decreased OKT4+/OKT8+ cell ratio. Total lymphocytes, T cells, Tm cells, Tg cells, T DR+ cells and B lymphocytes were normal. The results are similar to those founded in autoimmune diseases and suggest the existence of an immunopathogenic mechanism in these disease.

Adolescent↗

PubMed1985

[Analysis of circulating T-lymphocyte subpopulations with monoclonal antibodies in psoriasis].

Subsets of peripheral blood lymphocytes were studied by surface markers in 15 patients with psoriasis. Eighth of them had active lesions and 7 had stable lesions. The number of T cells was estimated by indirect immunofluorescence with the monoclonal antibodies OKT3. The number of T inducer cells was estimated with the monoclonal antibodies OKT4. The number of T suppressor cells was estimated with the monoclonal antibodies OKT8. The number of T activated cells was estimated with the monoclonal antibodies Edu 1. The patients with psoriasis had increased T cell number, decreased T inducer cell number and increased T activated cell number. The patients with active lesions had the most pronounced alterations of T cells subsets. In these patients was observed also a decreased T inducer/T suppressor cell ratio. The results, that show alterations in T cell number and it ratio are not able to establish or clarify an inducer or suppressor T cell activity in the course of psoriasis.

Adolescent↗

PubMed1985

[Cysts in retroauricular infundibulopapillary plaques].

Two female patients, with similar clinical characteristics, having as only dermatological manifestation large retroauricular plaques, on their surface could be seen many keratinic follicular cysts with an unspecific lichenoid inflammatory reaction. This entity is studied according to the revised bibliography, reaching the conclusion that they are real infundibulo-pilous cysts in plaques, with a very peculiar localisation, which are not red lichen planus. The authors think that this affection should be considered as an autonomous anatomo-clinical entity.

Cysts↗

PubMed1985

An open, multicentre assessment of the effectiveness of bifonazole in the treatment of tinea (pityriasis) versicolor.

One hundred and twenty-one patients with tinea (pityriasis) versicolor, confirmed by pretherapeutic clinical and mycological examination, were treated with a single daily application of bifonazole (BAY h 4502) 1% gel for 2 weeks. Weekly clinical controls were performed during the treatment period and at least two clinical and mycological post-therapeutic controls were given. Overall results were very good in 98 patients, good in 15, moderate in 7 and failure in 1 patient. Local tolerance was very good; only 1 patient presented with slight erythema and pruritus during the treatment.

Adolescent↗

PubMed1984

[Nickel sensitivity in an atopic patient].

A case of atopic dermatitis with it's classics signs in face and extremities, with an eight years evolution is reported. It was treated with corticoids (local and systemic) with no favorable results. In the allergic investigation it was found a sensibilization to nickel. She was cured by eliminating the nickel from her diet and from the objects in contact. Clinic and etiopathogenic considerations between allergic dermatitis by contact to nickel in the atopic and the non-atopic are made.

Adult↗

PubMed1984

[Lymphocytes and their subpopulations in psoriasis].

Peripheral blood lymphocytes and his subpopulations from 32 psoriatic patients were analyzed. For this, E rosettes for T cells, EAC rosettes for B cells and EA rosettes for receptors for Fc-IgM and Fc-IgG on T cells were employed. A decrease of circulating T cells is demonstrated as well an increase of null cells. No differences are observed for the number of circulating TM to TG cells (with Fc-IgM or Fc-IgG receptors). However, a decreased of T null(T/) cells was found. The authors postulate that the phenotypic appearances of T cells was associated to localize waste of modulated or activated T cells in lesions during the active phase of psoriasis.

Adolescent↗