[The importance of early excision of necrosis in the healing of burns].
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Biomedical subjects
Publications and source records attributed to R Vrabec.
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Using the collodion agglutination method the authors studied antibody formation against skin allografts in severely burned patients. They succeeded in detecting antibodies which start appearing on the third day following transplantation at the earliest. Later their titers increase reaching the maximum a few days before first signs of graft rejection. High titers persist for relatively long periods after graft rejection. Antibodies were not detected if the grafts were taken from an identical twin. In this case the grafts were not rejected. These results could be used for the determination of the optimal time for debridement of adhering allografts before the onset of rejection.
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It was shown in a group of 59 patients with large thermic injuries that neither surgical treatment and the type of anesthesia and/or possibly some other therapy such as modern antibiotics, nor the age factor influence significantly liver changes which can almost always be found in burns disease. Undoubtedly, primarily the period of sepsis or toxemia has an unfavourable hepatotrophic effect - the decisive role being played by the bacterial infection of wound surfaces. A clinical laboratory and morphological picture of liver changes is given.
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