PubMed Health⌕ Search

Biomedical subjects

R W Bain

Publications and source records attributed to R W Bain.

6 recordsLinked to original sources

Rapid onset of cervical cancer in an upper socioeconomic group.

In this series of 130 patients with cervical cancer, 25% had a short interval of less than 3 years from negative cytologic screenings to finding of cancer. In the short interval group, the peak age was 30 to 35 years, but lesions also developed in younger women and in women aged 60 years and older. The majority of lesions were still in situ, a lesser number had microinvasion and two had invasive squamous carcinoma. The usually accepted risk factors, low socioeconomic group, multiparity, and poor hygiene, did not prevail in all cases. Some patients had no history of pregnancy. They were not considered to be in a low socioeconomic group and poor hygiene was not an apparent feature. In view of the rapid onset of cervical cancer in some patients, even those not considered to be at high risk, annual screening is recommended for all age groups.

Adult↗

Lobomycosis. An electronmicroscopic, histochemical and immunologic study.

A 73-year-old woman from Guyana had nodular keloidal lesions on her face which had persisted for 56 years. A biopsy of the lesion revealed lobomycosis, a rare fungal infection. Microscopically, numerous fungi were seen in giant cells and macrophages. The macrophages had abundant pink reticulated cytoplasm. These macrophages in lobomycosis, considered by some in the past to be granular myoblastoma cells, were rich in glycoproteins and appeared to be "Gaucher-like cells" in electronmicrographs. Further, a transition of macrophages containing organisms to Gaucher-like cells was noted. Antibodies to the fungus were demonstrated in the patient's serum by counter immunoelectrophoresis and indirect immunofluorescence studies. We postulate that the Gaucher-like cells formed because of the inability of host macrophages to digest glycoproteins in the capsule of this unusual fungus.

Aged↗