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Biomedical subjects

R W Billington

Publications and source records attributed to R W Billington.

At least 19 recordsLinked to original sources
PubMed2000

Effect of monovalent ions in glass ionomer cements on their interaction with sodium fluoride solution.

The effects on surface morphology of glass ionomer cements following exposure to 0.2% NaF solution were studied. The effect of cement on the solution was also evaluated. The four cements were chosen to contain Na and F, Na alone, F alone and neither Na nor F to show any interactions produced by having the same ion in both the cement and solution. Four glass ionomer cements were formulated so that they differed only in respect of the glass component. AH2 (a glass used in dental restorative cement) contained both Na and F, MP4 (a glass used in orthopaedic cement) contained Na only, LG26 (a glass used in surgical cement) contained F only and LG30 (an experimental control glass) contained neither F nor Na. Discs of cement were set in moulds at 37 degrees C for 1 h, then matured in water for 3 d. Each test disc was then immersed in 10 ml 0.2% NaF for 24 h at 37 degrees C whereas control discs remained in water. The test and control disc surfaces were assessed qualitatively using electron microscopy and quantitatively by linear profilometry generating roughness values (Ra). Test solution pH was measured before and after cement immersion. Inspection of the electron micrographs showed considerable disruption of AH2 and LG26 test surfaces compared to their controls whereas MP4 and LG30 showed similar surfaces for test and control. Statistical analysis of the Ra values showed that AH2 and LG26 test surfaces were significantly rougher than their controls as well as LG30 and MP4 test surfaces, which were not significantly different from their controls. All NaF solutions show pH increases; those for AH2 and MP4 were significantly higher than those for LG26 and LG30. The F-containing cements were subject to surface disruption whereas F-free cements were not. The Ra values of test surfaces correlated strongly (r = 0.998) with the F uptake of the cements (data from a previous study) but it was not possible to ascribe the causality to this association. The pH changes appear to be influenced by whether or not Na is present in the cement. The resultant pH values are too near to neutral for pH alone to explain the surface disruption observed. In addition, it is concluded that the changes in OH ion concentration are too low to permit F-/OH- interchange as a possible explanation for F uptake by these cements.

Anions↗
PubMed2000

Effects of adding sodium and fluoride ions to glass ionomer on its interactions with sodium fluoride solution.

This investigates the effects of the addition of Na and F ions to a glass ionomer cement in which those ions are not inherently present on its interactions with dilute (0.2%) NaF solution. Both the effect of the solution on the cement's surface morphology and the effect of the cement on the solution in terms of take up of Na+ and F- and of change in pH are to be investigated. These results are to be compared to previous results obtained with glasses which contained both, one, or neither of the ions as components of their glasses. NaF (1.3% by weight in the mixed cement) was added to the powder components of a glass ionomer based on LG30 glass (which contains Al, Si, Ca, P, and O only). Discs of cement were set in moulds at 37 degrees C for 1 h then stored in water at 37 degrees C for 3 days. Each test disc was then immersed in 10 ml 0.2% NaF solution whereas controls remained immersed in water (N = 3 for test and control). Test and control disc surfaces were assessed both qualitatively by electron microscopy and quantitatively by linear profilometry (Ra values). Potentiometry was used to measure solution pH and Na and F concentrations using a pH electrode and suitable ion selective electrodes both before and after cement immersion. The surface of test specimens was subject considerable disruption with the polysalt cement matrix being removed and residual glass particles being disclosed. The controls showed no such disruption. This effect was reflected in a significant difference of Ra. Such an effect was not shown by test and control surfaces of LG30 but a similar effect was to that shown by LG26 (which contains F as a glass component). Solution pH changed by 1 unit which was much more than the change shown by LG30 or LG26 but is similar to that of AH2 and MP4 cements which both contain Na. The Na and F uptake was much lower than for LG30 whereas that of LG26 was higher than LG30. The Na:F ratio was 0.29:1 compared to 1.26:1 for LG30 (LG26 = 1.01:1, AH2 = 1.02:1, MP4 = 1.04:1). Fluoride addition to a F-free glass ionomer renders it vulnerable to surface disruption by NaF solution showing that fluoride complexes produced in glass dissolution are not necessarily involved in this process. Sodium addition to a Na-free glass ionomer confirms the role of this cement in enhancing pH change in NaF solution. The level of uptake of F- from a NaF solution in much lower than that for the F-free glass ionomer which shows there is no direct relationship between F- uptake and surface disruption. The ratio of Na:F uptake is below 0.3:1, but the pH change is similar to cements where the ratio is close to unity which indicates that F-/OH- interchange is not a significant mechanism even when anion/cation uptake is not balanced.

Anions↗
PubMed1999

Comparison of ion release from a glass ionomer cement as a function of the method of incorporation of added ions.

The addition of potassium and fluoride ions to a water-admixed glass ionomer cement initially free from either ion was accomplished either by addition via the mixing water or by immersing mixed set cement in a solution of the ions in water. In both cases the aqueous concentration of ions was the same. The release of both potassium and fluoride was measured for 500 days. Ion release from immersed specimens was some 20-fold higher than from the other method indicating enhanced concentration of ions inside the cement. This calculation assumes that the ions resided in the aqueous phase. Ions added by mixing appeared to follow the release pattern shown by glass ionomers containing intrinsic fluoride; ions added by immersion did not. As specimens matured the amount which could be taken up by immersion was reduced. Potassium release was still continuing at 500 days whereas fluoride release was complete.

Aluminum Oxide↗
PubMed1999

Effect of monovalent ions in glass ionomer on their uptake and re-release.

AIMS: The study aims to directly measure uptake of Na and F ions by glass ionomer cement from dilute NaF solution and compare this with the subsequent re-release of these ions into water. In addition, the effect of the presence or absence of Na and/or F as a component of the glass is evaluated. MATERIALS AND METHODS: The four glass ionomers used differed only in glass composition; AH2 contained both Na and F, LG26 contained F, MP4 contained Na and LG30 contained neither Na nor F. Discs of cement were set in moulds at 37 degrees C for 1 h and matured in water at 37 degrees C for 3 days. Test discs were immersed in 0.2% NaF solution for 24 h, control discs in water. Discs were subsequently immersed in water which was changed regularly. Ion-selective electrode measurements (F and Na) and atomic absorption spectrometry (Na) were used to determine uptake (change in immersion solution concentration) and re-release into water. RESULTS: All cements took up large quantities of Na and F ions (range 95-336 mumol g-1). This resulted in internal ion concentrations from 16 to 56 times higher than the immersing solution. All re-release was complete within 97 days. No cement re-released more ion than taken up. Glass ionomers containing fluoride took up more Na and F than fluoride-free ones and then re-released a lower percentage of these ions. The cements all took up Na and F ions in equimolar proportions, but initially re-released more F than Na with F-free cement results tending to unity by 97 days. CONCLUSIONS: Glass ionomer cements take up Na and F ions from NaF solution in large quantities and in equimolar proportion. This is re-released either wholly or in part in 97 days by which time the release does not differ from the controls. The presence or absence of F in the cement composition markedly influences both uptake and re-release. Fluoride/hydroxyl interchange does not appear to play an important role in uptake.

Acrylic Resins↗
PubMed1999

The influence of sample dimensions on fluoride ion release from a glass ionomer restorative cement.

The fluoride release from a commercial, restorative glass ionomer cement was found to be strongly dependent on sample surface area rather than volume. This was noted for disc, cylindrical- and bar-shaped specimens over periods ranging from 1 day to 3 yr. Release from all shapes of specimen followed the established pattern of an initial non-linear region followed by one where release was proportional to the square root of time. If fluoride levels in the cement matrix of specimens were artificially increased by incorporation during the mixing then the release pattern during the first few months was altered. The initial release increased for some specimen sizes and decreased for others. The dependency on surface area was greatly reduced for several months. By the time a year had elapsed the correlation between fluoride ion release and surface area had been re-established. The influence of additional fluoride during setting can therefore act to perturb the normal release pattern and may in some instances reduce the initial fluoride release. Release should be quoted in terms of, or with measurements of, the surface area of specimens under investigation.

Drug Stability↗
PubMed1998

Effect of moisture protective coatings on the strength of a modern metal-reinforced glass-ionomer cement.

The strength of a modern, low metal:glass ratio, metal-reinforced glass-ionomer cement was measured evaluating a number of protective barriers: one light-cured resin, two solvent-based dental varnishes and petroleum jelly. The cement was exposed to water at 10 and 60 min from start of mix. The results obtained with these protecting agents were compared with those obtained where no protection was applied. A comparison of uniaxial flexural strength and biaxial flexural strength showed the latter to be more discriminating. Proprietary dental varnishes were superior to petroleum jelly, producing similar strengths of 50 MPa. Petroleum jelly was, however, preferable to no protection. Moisture protection during the first 30 min was found to be beneficial, thereafter no further strength increase was found. A second material, a cement which has a high metal:glass ratio, was found to be more moisture resistant but weaker in strength than the modern material, with a biaxial strength of 39 MPa.

Cermet Cements↗
PubMed1997

Silver and fluoride ion release from metal-reinforced glass-ionomer filling materials.

This study was undertaken to examine whether a relationship exists between the composition of metal-containing glass-ionomer cements and ion release from these materials. Conflicting data on silver release from this type of material has been reported and it was felt that further investigation was desirable in view of the increasing use of these materials. In this study, the release of ions, particularly of silver and fluoride, into deionized water and artificial saliva was measured for up to one year. Low levels of silver and copper ions were found in both media. The amounts released from alloy-containing materials were dependent on the amount of alloy present; lesser amounts were leached from cermets. Fluoride ion release was less material-dependent but still lowest for cermets. The use of artificial saliva reduced ion release as did increasing the maturation time prior to immersion in either liquid.

Aluminum↗
PubMed1996

An in vitro microleakage study of three restorative techniques for Class II restorations in posterior teeth.

Microleakage associated with a silver reinforced restorative glass ionomer cement used alone and also as a laminate restoration with a composite resin and dentine adhesive in extracted premolar and molar teeth was evaluated. The influence of artificial saliva, thermal and load cycling was also determined. The composite and dentine adhesive alone were used for comparative purposes. The results showed that the composite resin/dentine adhesive restorations showed substantial microleakage at both the cervical and occlusal margins of the Class II restorations, whereas the glass ionomer alone showed little or no leakage after storage in water for seven days at 37 degrees C. These results were confirmed when the restorations were thermo-cycled and load stressed. The addition of glass ionomer as a base to the composite forming the laminate restoration reduced the leakage substantially and in certain conditions the leakage was less than that observed with glass ionomer restoratives alone.

Dental Leakage↗
PubMed1994

Zinc phosphate cements: an evaluation of some factors influencing the lactic acid jet test erosion.

The lactic acid jet test was used to measure erosion rates of eight commercial zinc phosphate cements at 23 and 37 degrees C after 24 h and 2 months. Rates exceeded the ISO 9917 published limit of 0.1 mm/h when tested according to this specification (23 degrees C, 24 h), suggesting the limit should be increased. Erosion was measured by both weight loss and depth change. At 24 h erosion decreased as temperature increased, whereas after 2 months temperature had no significant effect. No trend was seen with increasing specimen maturity. Stannous fluoride may increase erosion resistance.

Hot Temperature↗
PubMed1993

Lactic acid jet test: in vitro erosion rates of glass ionomer dental cements containing radiopacifying elements.

The lactic acid jet test erosion rates were measured for 13 radiopaque glass ionomer dental materials obtained from a number of manufacturing sources. The erosion rate was compared with that found for the non-radiopaque restorative from the same manufacturer to determine whether the addition of an extra element had affected the resistance to erosion. Six materials were not significantly affected, six showed a significant increase in erosion rate. Only one material showed a reduced erosion rate. Materials containing a high proportion of any additive could show an increased erosion rate. Glass ionomer cements with or without radiopacifying elements had low erosion rates compared with other dental materials.

Alloys↗
PubMed1992

The comparative strengths of commercial glass-ionomer cements with and without metal additions.

Metal reinforced glass-ionomer cements are said to possess superior mechanical properties when compared to non-metal reinforced glass-ionomer cements. However, the literature to date does not always support this view, owing to the variety of materials and test methods employed. In this study the mechanical properties of three reinforced and three standard materials were tested using the standard specification tests of compressive and diametral strength in addition to tensile strength using the four point bend test. The tensile strength was also measured using the shell test in order that this test, which on theoretical grounds is more suited to these materials, may be evaluated. Six specimens of each material were prepared for each of the test modalities resulting in the conclusion that the addition of metal to glass-ionomer cements can markedly increase the strength of the materials. However, the method of fusing the metal to the glass rather than by simple addition does not produce any advantages in strength. In this evaluation one reinforced material was significantly stronger than all other materials in all four test modalities. The compressive strength test which appears in most standards does not appear to be very discriminatory. Of the tensile tests, which have more clinical significance, the results of the diametral strength tests, which are included in some standards, appear to be at variance with the other two tensile tests, suggesting that the flexural or shell test would be more appropriate.

Cermet Cements↗
PubMed1992

In vitro erosion of 20 commercial glass ionomer cements measured using the lactic acid jet test.

The lactic acid jet test has been proposed for incorporation in international standards for dental cements, since results correlate well with in vivo erosion. In the literature, jet test results have been reported on only six glass ionomer cements. This study examines three types of glass ionomer, restorative, luting and metal reinforced, twenty materials from six manufacturers. A wide range of erosion rates was found particularly for restorative cements. The hypotheses put forward by previous workers to explain differences in erosion rates found on their limited range of glass ionomers do not apply to the wider range that we tested.

Biocompatible Materials↗
PubMed1991

Changes in compressive strength of glass ionomer restorative materials with respect to time periods of 24 h to 4 months.

This study investigated whether long-term changes occur in the compressive strength of a number of glass ionomer restorative materials, in view of the fact that little information is available from the manufacturers, and any variations with time might affect suitability for clinical use. It was found that, over the period of 24 h to 4 months, some materials, namely those based on polyacrylic acid, maintained or even showed a slight increase in their strength, whereas others based on copolymers of acrylic acid first increased in strength, but thereafter showed deterioration. In one case the strength decreased by nearly 50% compared to that at 24 h.

Dental Restoration, Permanent↗
PubMed1991

Natural killer cells and the post viral fatigue syndrome.

60 patients were referred with a diagnosis of post viral fatigue syndrome (PVFS), but only 50 fulfilled strict criteria for this illness. Many lymphocyte subpopulations were normal, but there was a spectrum of natural killer (NK) cell results: 20/50 (40%) were raised; 8/50 (16%) were low;, 5/50 (10%) were low initially but normal on repeat testing; 17/50 (34%) were normal. When patients were categorised on their NK cell results, there were significant differences in the two groups with raised or low NK cells compared to the "Not PVFS" group: the CD8 cells were increased (p less than 0.001, p less than 0.02) and the CD4/CD8 ratio was reduced (p less than 0.05) but the CD4 cells were normal. Clinical data showed that the "Not PVFS" group were older, with less severe illness, less muscle pain and less virological evidence of infection. It is postulated that patients have low NK cells initially and then progress to normal or raised levels dependent on factors such as stress, other infections and behaviour.

Adult↗