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Biomedical subjects

R W Bruce

Publications and source records attributed to R W Bruce.

10 recordsLinked to original sources
PubMed2000

Influenza A induced rhabdomyolysis resulting in extensive compartment syndrome.

This is a case of influenza A induced rhabdomyolysis resulting in extensive compartment syndrome and acute renal failure in a 10-year-old child. The patient required fasciotomies in all four extremities. Even after fasciotomies were performed, the muscle tissue continued to swell, suggesting a primary myositis. This case emphasizes the importance of considering the diagnosis of compartment syndrome in patients with influenza infection and severe myalgia.

Acute Kidney Injury↗
PubMed1998

Pseudoparalysis of the lower extremity in an infant.

We describe a case of septic arthritis of the knee in an afebrile, well-appearing four-month-old female. She had been evaluated previously for lower extremity disuse attributed to antecedent trauma. Her physical examination was remarkable only for limitation of extension of the affected leg at the knee. Emergency physicians should understand the physical examination findings suggesting joint effusion and the need to consider osteomyelitis/septic arthritis in children less than one year of age with pseudoparalysis.

Arthritis, Infectious↗
PubMed1996

Torsional and angular deformities.

A general understanding of the cause and natural history of rotational and angular malalignment of the lower extremity allows accurate differentiation between pathologic and physiologic conditions. One can then educate the involved and often concerned family and proceed with observational management of physiologic conditions as spontaneous improvement of alignment can be expected. Aside from treatment for resistant metatarsus adductus, other forms of treatment, such as special shoes, casts, or braces, are rarely beneficial and have no proven efficacy. Persistent deformity beyond skeletal maturity is unusual and rarely causes significant functional disability. In rare cases of severe residual deformity, operative correction is the only effective treatment.

Age Factors↗
PubMed1990

Long-term effects of dietary calcium on risk markers for colon cancer in patients with familial polyposis.

There is conflicting evidence regarding the benefit of calcium in prevention of colon cancer. Patients who have undergone ileorectal operations for familial polyposis can be useful to study hypotheses on prevention of colon cancer. In this study we evaluated the effect of long-term calcium supplementation on risk markers of colon cancer. Thirty-one patients with familial polyposis, after subtotal colectomy, were randomized to group A, which received placebo, and group B, which received 1200 mg of calcium daily. Intervention lasted 9 months, in which they underwent four 3-monthly evaluations that included food records, fecal pH, calcium and bile acids, and rectal biopsy for thymidine labeling. Age, height, weight, macronutrients, and dietary fiber were comparable in both groups. More women were in the group that received placebo. Fecal pH, weight, and bile acid levels were similar before intervention and remained unchanged. Fecal calcium levels were similar before intervention and increased in the calcium group throughout the study (p less than 0.05). Labeling index of placebo and calcium groups was similar before intervention (4.8 and 6.1, respectively). After 3 months it was reduced in both groups (3.1 and 4.4, respectively; p less than 0.05). After 6 months it was reduced only in the calcium group (3.4; p less than 0.05). After 9 months it did not differ from the starting point (3.4 and 4.0, respectively). In a long-term intervention study with a homogenous group of patients with familial polyposis, supplemental dietary calcium did not affect mucosal risk factors for colon cancer.

Adenomatous Polyposis Coli↗
PubMed1984

A model study of fecapentaenes: mutagens of bacterial origin with alkylating properties.

Fecapentaene-14 and -12 are directly acting mutagens that do not require metabolic activation. Their unusual structure suggests a possible mechanism of action. A carbocation that is formed by the addition of an electrophilic species (such as a proton) to the enol ether is most probably the reactive species. A series of model enol ethers with conjugated systems of various lengths was prepared, and a correlation between mutagenicity and increasing reactivity of derived carbocations was found. The glycerol moiety does not play a crucial role in the overall reactivity of the fecapentaenes.

Alkylating Agents↗
PubMed1983

Glycogen depletion and lactate responses in freestyle wrestling.

Metabolic responses to international freestyle wrestling were investigated in six university wrestlers, four of whom were studied on two separate occasions. Lactate concentration in venous blood averaged 10.5 mM after the six minute bouts, while blood pH was (p less than 0.01) reduced to 7.063 +/- 0.061 (mean +/- S.D.) after wrestling. Glycogen concentration in biopsy samples from the vastus lateralis muscle was lower by 10.0 +/- 4.4 mmoles glucose units/kg wet muscle weight (p less than 0.01) after, compared to before wrestling. Evaluation of glycogen utilization in individual muscle fibre types using the periodic acid Schiff histochemical stain revealed that glycogen depletion, although modest, was similar in ST, FTa and FTb fibres. These data demonstrate that wrestling involves significant anaerobic metabolism, and that the vastus lateralis muscle is significantly involved in wrestling performance.

Adult↗