Biomedical subjects

R W Dellers

Publications and source records attributed to R W Dellers.

9 recordsLinked to original sources

PubMed1984

Acute diarrhea in horses of the Potomac River area: examination for clostridial toxins.

Fecal specimens from horses in Montgomery County, Md, and in Fairfax and Loudoun counties, Va, were examined for Clostridium perfringens type A enterotoxin and for C difficile cytotoxin (92 and 108 specimens, respectively). The toxins were found in feces from horses that had experienced an acute diarrhea syndrome and from clinically normal horses. The toxins did not appear to be primary determinants of the diarrhea syndrome, although they may have contributed to the spectrum of clinical entities observed.

Acute Disease↗

PubMed1984

Heterogeneity of contagious ecthyma virus isolates.

Results of cross-neutralization tests of 4 isolates of contagious ecthyma (CE) virus and their antisera indicated that the isolates were neutralized to various degrees by the CE virus antisera. Cross-reactions among isolates were unilateral, but not bilateral, and therefore grouping of CE virus isolates by neutralization tests was not possible to obtain. Structural analysis of polypeptides from 11 isolates of CE virus by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that the profiles obtained were similar to one another, except for differences observed in the molecular weight region of 37,000 to 44,000. On the basis of these differences, the isolates could be classified into 4 groups. The polypeptides which varied among the different isolates were shown to be in the surface component of the virion and appeared to be components of the surface tubules. Unilateral cross-reactions detected in cross-neutralization tests were found to correlate with the 37,000 to 44,000 dalton polypeptide grouping of the isolates.

Animals↗

PubMed1984

Contagious ecthyma virus-vaccination failures.

Cross-protection experiments were undertaken to investigate reasons for contagious ecthyma (CE) virus-vaccination failures. Vaccination with sheep-passaged or with cell culture-passaged virus did not protect lambs against development of lesions after challenge inoculation with sheep-passaged virus. However, lesions which developed after challenge exposure with sheep-passaged CE virus healed significantly faster than did those induced by the initial vaccination with sheep-passaged virus (P less than 0.001). A significant decrease in the healing time was not observed for lambs initially vaccinated with cell culture-passaged CE virus after challenge exposure with sheep-passaged virus (P greater than 0.05). Protection was evident when lambs were challenge inoculated with the less virulent cell culture-passaged virus and cross-protection between the ST and CSL isolates was detected. This study indicated that complete protection even against homologous strain challenge was not achieved. Antigenic differences between vaccinal and field strains appeared an unlikely cause of vaccination failures. It also is evident that cell culture-propagated CE virus preparations are less effective for vaccination purposes than are those propagated in sheep.

Animals↗

PubMed1975

Adenoviral pneumonia in a foal.

A three-week-old Arabian filly was admitted to the Large Animal Hospital with a respiratory disorder and died despite symptomatic treatment. The necropsy lesions were suggestive of viral pneumonia. An equine adenovirus were isolated from nasal and pharyngeal swabs and from several tissues after death. Typical adenovirus virions were demonstrated by electron microscopy.

Adenoviridae↗

PubMed1974