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Biomedical subjects

R W Field

Publications and source records attributed to R W Field.

At least 37 records · Page 2Linked to original sources
PubMed1998

Residential 222Rn exposure and lung cancer: testing the linear no-threshold theory with ecologic data.

In most rigorous epidemiologic studies, such as case-control and cohort studies, the basic unit of analysis is the individual. Each individual is classified in terms of exposure and disease status. However, in ecologic epidemiologic studies, the unit of analysis is some aggregate group of individuals. Summary measures of exposure and disease frequency are obtained for each aggregate, and the analyses focus on determining whether or not the aggregates with high levels of exposure also display high disease rates. The ecologic study design has major limitations, including ecologic confounding and cross level bias. Cohen has attempted to circumvent these limitations by invoking the linear no-threshold theory of radiation carcinogenesis to derive aggregate "exposures" from individual-level associations. He asserts that, "while an ecologic study cannot determine whether radon causes lung cancer, it can test the validity of a linear-no threshold relationship between them." Cohen compares his testing of the linear no-threshold relationship between radon exposure and lung cancer to the practice of estimating the number of deaths from the person-rem collective dose, dividing the person-rem by the number of individuals in the population to derive the individual average dose, and then determining individual average risk by dividing the number of deaths by the number of individuals in the population. We show that Cohen's erroneous assumptions concerning occupancy rates and smoking effects result in the use of the wrong model to test the linear no-threshold theory. Because of these assumptions, the ecologic confounding and cross level bias associated with Cohen's model invalidate his findings. Furthermore, when more recent Iowa county lung cancer incidence rates are regressed on Cohen's mean radon levels, the reported large negative associations between radon exposure and lung cancer are no longer obtained.

Air Pollutants, Radioactive↗
PubMed1998

Spatial variation of residential radon concentrations: the Iowa Radon Lung Cancer Study.

Homeowners and researchers frequently estimate the radon concentrations in various areas of the home from a single radon measurement often performed in the home's basement. This study describes the spatial variation of radon concentrations both between floors and between rooms on the same floor. The geometric mean basement and first floor radon concentrations for one-story homes were 13.8% and 9.0% higher, respectively, as compared to their counterparts in two-story homes. The median first floor/basement ratio of radon concentrations for one-story homes was 0.60. The median ratios between first floor/basement and second floor/basement for two-story homes were 0.51 and 0.62, respectively. The mean coefficient of variation for detectors placed on the same floor was 9.5%, which was only 2.6% higher than the mean coefficient of variation found for collocated (duplicate) quality control detectors. The wide individual variations noted in radon concentrations serve as a reminder of the importance of performing multiple radon measurements in various parts of the home when estimating home radon concentrations.

Adult↗
PubMed1997

Predicting end-of-test semen quality in bulls prior to performance testing.

The first objective of this study was to determine if serum concentrations of specific hormones (testosterone, progesterone and androstenedione) in bulls at the start of performance testing could predict semen quality at the end-of-test when used in a multivariate model. The second objective was to evaluate other clinical measurements (breed, age, body weight, hip height and scrotal circumference) for predicting end-of-test semen quality. End-of-test semen quality was related to steroid concentrations and several pre-testing measurements, including age, body weight, hip height and scrotal circumference (SC). Combining the 3 steroid concentrations into a predictive test had a sensitivity of 0.6 and specificity of 0.5 at its most accurate point. The repeatability of the test result was extremely low (r(2) = 0.16; P < 0.05). In multivariate analyses, breed and start-of-test SC remained significant predictors of end-of-test semen quality (P < 0.05) while the other variables were nonsignificant (P > 0.1), suggesting that start-of-test SC was the most accurate predictor of end-of-test semen quality. Removing bulls at the start-of-test that had scrotal measurements of less than 20 cm, 24 cm, 28 cm or 32 cm resulted in sensitivities and specificities of 0.19, 0.94; 0.41, 0.81; 0.64, 0.56; and 0.94, 0.12, respectively. No cut-point had both adequate sensitivity and specificity. Because clinical tests were correlated, combining the tests to improve accuracy was not justified.

Journal Article↗
PubMed1996

Occupational exposure of water-plant operators to high concentrations of radon-222 gas.

Water-plant operators may be exposed to high airborne radon-222 (222Rn) concentrations created when 222Rn gas transfers from water to air during the water treatment processes. To evaluate this hazard, we placed yearlong alpha-track radon detectors in 31 water plants. The geometric mean of the annual average airborne 222Rn concentrations was 3.4 pCi L-1 (126 Bq m-3), with a maximum of 133 pCi L-1 (4921 Bq m-3). We assessed the short-term temporal variability of 222Rn by monitoring four water plants continuously for a 3- to 6-day period. Cumulative working level months were estimated for the time workers were in the water plants. Because airborne 222Rn concentrations in water plants can reach levels considered unsafe for underground miners, it would be prudent to monitor airborne 222Rn concentrations in water plants which aerate water as part of their treatment process.

Air Pollutants, Radioactive↗
PubMed1995

Use of performance ratios to calculate the economic impact of thin cows in a beef cattle herd.

OBJECTIVE: To determine gross income lost that was attributable to thin cows in a beef cattle herd, to estimate the cost of added nutrition necessary to prevent thin cows in the herd, and to determine the financial outcome of the improved nutritional practices. DESIGN: Prospective, observational study. ANIMALS: Four hundred and twenty-two Santa Gertrudis cows and their calves. PROCEDURE: At pregnancy examination in the fall of 1992, cows were assigned a body condition score (BCS), using a scale of 1 (emaciated) to 9 (obese), and the ratio of the productivity of BCS-3 and BCS-4 cow groups (thin cows), compared with the mean productivity of BCS-5 and BCS-6 cows (cows in good condition), was determined. Measures of productivity evaluated included pregnancy rates, weaning weights, and prices per hundredweight of calves. The performance ratios of BCS-3 and BCS-4 cows were multiplied by the mean gross income of BCS-5 and BCS-6 cows to calculate their gross income. This was then subtracted from the mean income of BCS-5 and BCS-6 cows to estimate the amount of lost gross income per thin cow. The cost of a nutritional program that would prevent thin cows in the herd was subtracted from the lost gross income of the thin cows to yield the amount of increased net income that could be generated from a nutritional program that would maintain cows in the herd at a BCS of 5 or 6. RESULTS: Cows with a BCS of 3 were 0.48 as productive, and cows with a BCS of 4 were 0.74 as productive as the average of the BCS-5 and BCS-6 cows combined. Each BCS-3 cow generated $215.06 less, and each BCS-4 cow generated $107.53 less gross income than the average gross income of BCS-5 and BCS-6 cows. The added cost of nutrition that would have reconditioned BCS-3 and BCS-4 cows to a BCS of 5.5 was $91.48/BCS-3 cow and $43.67/BCS-4 cow. Implementation of the reconditioning nutrition program the previous fall would have resulted in an extra net income of $123.58/BCS-3 cow and $63.86/BCS-4 cow, received over a 2-year period. The 262 thin cows in the herd accounted for a total net income loss of $19,897. CLINICAL IMPLICATIONS: The time of pregnancy examination is a strategic intervention point to estimate the past negative economic impact of thin cows and to implement a plan to prevent these losses in the future. Pregnancy examinations should be performed at least 100 days before the beginning of the calving season, and thin pregnant cows should be sorted into a special group and fed a reconditioning diet that will improve their body condition to an average BCS of 5.5 by the onset of the calving season.

Animal Husbandry↗
PubMed1995

Vertebral fracture associated with trauma during movement and restraint of cattle.

Two female Limousin calves in a group of 68 calves suffered fractures of a lumbar vertebra subsequent to moving through a chute and being restrained to facilitate administration of vaccines. One calf collapsed as it exited the chute, whereas the second calf collapsed 10 minutes after it was released from the chute. Both heifers were euthanatized. The fractures, of the first lumbar and of the third lumbar vertebral bodies, respectively, were not associated with mineral imbalances. Fractures were determined to be the result of calves attempting to escape through a gap formed by erosion of the area beneath a gate in the holding pen of the corral system. By moving cattle in such a way as to bypass the gate, further injuries were avoided. The calves described here underscore the importance of the use of corral systems appropriate for cattle of various sizes and the necessity of maintaining properly repaired corral systems to prevent injuries to cattle.

Animal Husbandry↗
PubMed1995

Radium-bearing pipe scale deposits: implications for national waterborne radon sampling methods.

A point-of-use waterborne radon-222 (222Rn) survey of a small Iowa town was performed to determine the cause of unnaturally high waterborne 222Rn concentrations in the municipality. The source of the elevated 222Rn concentrations was a newly discovered reservoir of waterborne 222Rn originating from distribution-system radium-226 (226Ra) adsorbed internal pipe scale deposits. Because the proposed national drinking water regulations for 222Rn require sampling at the origin of the distribution system rather than at the point of use, the proposed scheme for collection of water samples may not represent actual consumer waterborne 222Rn exposure in all cases.

Environmental Monitoring↗
PubMed1994

Investigating perinatal calf mortality in beef herds.

This article summarizes the information presented in this issue to identify the reasons for a perinatal calf mortality (PCM) problem through a risk-factor-evaluation approach. The benefits of necropsies in PCM investigations are discussed, and the gross lesions of the major causes of PCM are described. The use of 2 x 2 tables to calculate odds ratios and the Chi-square method to test the validity of the odds ratios are presented as methods to determine suspected risk factors. The article concludes with a discussion of the management plan used to solve a PCM problem.

Animals↗
PubMed1994

Residential radon exposure and lung cancer: evidence of an urban factor in Iowa.

An ecological study of lung cancer, cigarette smoking, and radon exposure was conducted in 20 Iowa counties. County-based lung cancer incidence data for white female residents of Iowa were stratified according to radon level and smoking status. Cancer incidence data for the period 1973-1990 were obtained from the State Health Registry of Iowa. Smoking level was determined from a randomly mailed survey. Radon level was determined according to an EPA supported charcoal canister survey. Within low smoking counties, rates for all lung cancer and small cell carcinoma were significantly lower (p < 0.05) in the high radon counties relative to the medium and low radon counties. However, within high smoking counties, rates for all lung cancer, adenocarcinoma, and small cell carcinoma were significantly higher (p < 0.05) in the high radon counties relative to the low radon counties. Variations in socioeconomic data for these counties, available through the 1980 and 1990 census, did not explain these results. Lung cancer rates also were significantly increased in urban counties even after holding smoking status constant. Multivariate analyses revealed significant interactions between smoking, urbanization, radon levels, and lung cancer. The results of this hypothesis generating study will be tested in a case/control study now ongoing in Iowa. Analysis will need to include separate evaluations by smoking status, radon level, and residence in urban or rural areas for the major morphologic types of lung cancer.

Adenocarcinoma↗
PubMed1993

137Cs levels in deer following the Three Mile Island accident.

White-tailed deer (Odocoileus virgianus) tongues were assayed to assess whether or not significant widespread 137Cs contamination occurred in the vicinity of Three Mile Island Nuclear Station as a result of the 1979 accident. White-tailed deer tongues harvested from 10 Pennsylvania counties more than 88 km away from Three Mile Island had significantly higher 137Cs levels than deer tongues harvested from counties surrounding the nuclear plant. The mean deer tongue 137Cs levels found in Pennsylvania white-tailed deer were lower than 137Cs levels found in deer from other parts of the U.S. sampled shortly after culmination of major atmospheric nuclear testing. These findings support the conclusions of previous studies suggesting that only minimal quantities of 137Cs escaped from the damaged Three Mile Island plant after the accident.

Accidents↗
PubMed1993

Factors associated with elevated 222Rn levels in Iowa.

The University of Iowa, in conjunction with the Environmental Protection Agency's State Radon Survey Assistance Program, performed a 222Rn screening survey of 582 rural households in the winter of 1989. The distribution of maximum indoor 222Rn concentrations throughout Iowa as well as the relationship between 222Rn screening measurements, detector placement, and housing characteristics are summarized. This report is unique in that site-specific home construction characteristics were collected in the field from participants prior to 222Rn monitoring. The findings of the survey indicate that the significance of a particular housing characteristic on a 222Rn screening measurement is dependent on the placement of the radon detector.

Air Pollution, Indoor↗
PubMed1993

Radon testing behavior in a sample of individuals with high home radon screening measurements.

Although radon exposure has been identified as the second leading cause of lung cancer, fewer than 6% of U.S. homeowners test their homes for radon. This report examines participants' follow-up radon testing behavior subsequent to receiving an initial screening radon level greater than 20 pCi/L. Sixty-two participants in the Iowa State-Wide Rural Radon Screening Survey who had radon screening measurements over 20 pCi/L were questioned by phone survey 3 months after receipt of their radon screening result to assess: whether participants were aware of radon's health risk; if participants recalled the radon screening results; how participants perceived the relative health risk of radon and whether participants planned follow-up radon testing. Only 19% of the respondents specifically identified lung cancer as the possible adverse health outcome of high radon exposure, and the majority of participants underestimated the health risks high radon levels pose when compared to cigarettes and x-rays. In addition, less than one third (29%) of the participants actually remembered their radon screening level within 10 pCi/L 3 months after receiving their screening results. Only 53% of the individuals correctly interpreted their screening radon level as being in the high range, and only 39% of the participants planned follow-up radon measurements. Receipt of radon screening test results indicating high radon levels was not an adequate motivational factor in itself to stimulate further radon assessment or mitigation. Our findings suggest that free radon screening will not result in a dramatic increase in subsequent homeowner initiated remediation or further recommended radon testing.

Environmental Exposure↗
PubMed1990

Field comparison of several commercially available radon detectors.

To determine the accuracy and precision of commercially available radon detectors in a field setting, 15 detectors from six companies were exposed to radon and compared to a reference radon level. The detectors from companies that had already passed National Radon Measurement Proficiency Program testing had better precision and accuracy than those detectors awaiting proficiency testing. Charcoal adsorption detectors and diffusion barrier charcoal adsorption detectors performed very well, and the latter detectors displayed excellent time averaging ability. Alternatively, charcoal liquid scintillation detectors exhibited acceptable accuracy but poor precision, and bare alpha registration detectors showed both poor accuracy and precision. The mean radon level reported by the bare alpha registration detectors was 68 percent lower than the radon reference level.

Air Pollutants↗
PubMed1989

Effect of induction of parturition on immunoglobulin content of colostrum and calf serum.

Thirty-four pregnant crossbred beef cows were injected with prostaglandin F(2) alpha (PGF group, n = 11), dexamethasone (DEX group, n = 11), or saline (control group, n = 12) on Day 270 of gestation. Immediately after calving, all colostrum was milked from each cow. A sample was taken, and the remainder was fed to that cow's calf within one hour of birth. Serum was collected from each calf at 0 and 24 h of age. Immunoglobulin G (IgG) content of colostrum and serum was determined with commercial radial immunodiffusion plates. The data from four PGF cows that did not calve until after 140 h post injection were excluded from the results. Mean (+/- SD) volumes (ml) of colostrum were 2086 (+/-1148.4) for the PGF group, 1336 (+/-583.7) for the DEX group, and 2404 (+/-1140.7) for the control group. Mean (+/- SD) concentrations (mg/dl) of IgG in colostrum were 6017 (+/-3351.2) for PGF, 10285 (+/-5370.7) for DEX and 10766 (+/-5098.3) for the control group. Mean (+/- SD) total quantities of IgG (g) in colostrum were 133.9 (+/-120.03) for PGF, 134.1 (+/-96.67) for DEX and 235.6 (+/-147.22) for the control. IgG concentrations were very low or were not detectable in serum of all calves prior to administration of colostrum. Mean (+/- SD) concentrations (mg/dl) of IgG in serum of calves at 24 h of age were 1469 (+/-905.8) for calves from PGF cows, 1819 (+/-1289.8) for calves from DEX cows, and 3317 (+/-1888.2) for calves from control cows. Calves from control cows had significantly more IgG at 24 h than calves from PGF cows or DEX cows (p<0.05). Calves born to cows induced to calve early may be at an increased risk of failure of passive transfer and so should be monitored for IgG concentrations.

Journal Article↗
PubMed1988

Use of the sustained-release morantel bolus in stocker calves in southern United States.

Two groups of 21 mixed-breed heifers were wintered on separate permanent pastures. Each heifer from one group was administered a sustained-release morantel bolus on October 7 (day 0), and the other group remained as untreated controls. Body weights were determined and fecal samples were taken at 28-day intervals. At the onset of the trail and at every 56 days, 6 heifers were removed from each group for slaughter to determine the developmental stages and the number of gastrointestinal nematodes. In addition, 3 tracer calves that were free of gastrointestinal nematodes were released on each pasture for 28 days at the beginning of the trail and after the last experimental-group calves had been removed. The 6 calves slaughtered on day 0 of the trail had a mean of 5,544 gastrointestinal nematodes. Tracer calves released on day 0 and removed on day 28 of the trial acquired 31,143 and 30,530 gastrointestinal nematodes from the pastures containing the treated and control heifers, respectively. Throughout the trial, the number of nematodes in the control calves increased at each sampling date (mean, 126,168 worms), whereas the mean number of worms in the treated heifers was 45,458. Tracer calves placed in the pastures after the 168-day trail acquired significantly more worms (9,632 vs 2,899; P less than 0.05) from grazing the pastures with control heifers than from grazing the pastures with treated heifers. Counts of eggs per gram of feces were significantly different (P less than 0.01) between the 2 groups from day 28 through day 112.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗